［摘 要］ 目的： 探讨美心力（cAMP）对左室功能和血流动力学的影响。方法： 建立心内植入压力、容积测定装置的犬模型，利用压力-容积关系分析美心力对左室功能和血流动力学的影响。结果： 美心力明显减慢心率（HR），降低总外周阻力（TSR），使左室收缩末期压力（PES）、容积（VES）和舒张末期压力（PED）、容积（VED）明显下降；并加速左室舒张速率（Tc），使每搏容积（SV）及射血分数（EF）增加。对于左室PES-VES、左室压上升大速率（dp/dt max）-VED和心搏功（SW）-VED 3种关系斜率及位置无影响，表明无正性肌力作用。结论：美心力无正性肌力作用，但能够降低心脏负荷，改善心肌舒张功能，增加心排血量。
作者：李为民；李悦；王伟宇；杨树森；韩薇 刊期： 2001年第03期
目的：探讨血管紧张素 Ⅱ（AngⅡ）对离体大鼠心肌缺血后再灌注心律失常的影响及可能机制。方法：用双冠脉分别灌流大鼠心肌缺血模型，将不同药物注入左冠脉，经 12 min低流量缺血，观察再灌注后 5 min室性心动过速（AT）及室颤（VF）的发生率。结果：脱氧肾上腺素(PH)可明显加重再灌注心律失常，单独应用AngⅡ无明显作用。而AngⅡ 2型受体阻滞剂PD123319（PD）与AngⅡ合用可明显增加再灌注心律失常。用选择性Na+/H+交换（NHE）阻滞剂HOE642及蛋白激酶 C阻滞剂 GF109203X（GF），可完全阻断此作用。结论：AngⅡ可通过兴奋AngⅡ 1型受体加重再灌注心律失常。AngⅡ 2型受体的兴奋可能有抑制再灌注心律失常的作用，机制可能与PKC中介的NHE活性增加有关。
作者：贾大林；郑晓伟；齐国先；胡健；曾定尹 刊期： 2001年第03期
Currently, platelet transfusion is the primary treatment for thrombocytopnia which results from intensive chemotherapy and radiotherapy of cancer. While repeated platelet transfusions are associated with several problems. The clinical availability of safe and effective platelet growth factors is eagerly awaited. Currently, a mumber of hematopoietic growth factors with thrombopoietic activity have been identified. This review discusses the biological characteristics and the clinical trial investigation development of platelet growth factors.
作者：欧瑞明；钟雪云；陈运贤 刊期： 2001年第03期
Obese gene was cloned and its protein product which named leptin was found to be expressed specially in fat tissues in 1994. As a metabolic signal of reproductive system, leptin reflects the situations of nutrition and energy, which the body supplys to the brain, and stimulates reproductive endocrinology system, then regulates the functions of reproduction through hypothalamic-pituitary-gonadal axis. The present status of leptin in this field was reviewed.
作者：郑育声；朱伟杰；谢琪璇 刊期： 2001年第03期
α-MSH is an endogenous neuropetide that is effective of all categories of expreimental inflammation. The mechanisms underlying the anti-inflammatory influence of α-MSH are reviewed in the article. α-MSH suppresses inflammation in the CNS and periphery by downregulating the activation of NF-κB, then inhibiting production of proinflammatory cytokines, nitric oxide, chemokines and adhension molecules, and increasing synthesis of anti-inflammatory cytokines. α-MSH is useful in the treatment of many pathological situations in humans.
作者：陈波；胡巢凤；王华东；林晨；李楚杰 刊期： 2001年第03期
