While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics.
作者： 刊期： 2006年第03期
Arsenic exposure has been associated with the development of skin lesions such as hyperpigmentation, hypopigmentation and hyperkeratosis, which may be harbingers of increased risk for cancers of the skin, bladder, lung and other organs.
作者： 刊期： 2006年第03期
Many organic pollutants occur in drinking water in considerable amounts, and mimic or interfere with reproductive development and function. Furthermore, it is not known whether multiple organic pollutants (MOP) from drinking water induce uterotrophic effects.
作者： 刊期： 2006年第03期
Beginning from the report of the renal injury induced by aristolochic acid, the poisonous side effects of Chinese medicines have attracted more and more attentions, which have produced huge influence on the progress of traditional Chinese medicines.
作者： 刊期： 2006年第03期
5-Flourouracil(5-FU) is one of well known anti-cancer drugs, but its toxicity in normal lymphocytes remains a major problem in chemotherapy. The eastern traditional drug, Bupleuri radix(BR), has been used for the treatment of liver diseases and contains series of triterpene saponins.
作者： 刊期： 2006年第03期
Toxicologists play a significant role in evaluating the potential adverse effects of chemicals in the workplace and in the environment at large. They are intimately involved in the processes of research, risk assessment and related regulatory affairs.
作者： 刊期： 2006年第03期
Acrylamide has been brought to the world attention in 2002 with the information that it was found contaminated in many heat treated carbohydrate rich foods. This creates a lot of concern worldwide since the appearance of Aflatoxins many decades ago.
作者： 刊期： 2006年第03期
Toxicity to the immune system encompasses suppression or enhancement of the immune response. Suppression of the immune response can lead to decreased host resistance to infectious agents or tumor cells. Enhancing the immune response can exaggerate autoimmune diseases or hypersensitivity.
作者： 刊期： 2006年第03期
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can cause cellular damage implicated in pathogenesis of a wide range of human disorders, including cancer, autoimmune disease, diabetes, cardiovascular disease and neurodegenerative disease.
作者： 刊期： 2006年第03期
Myeloperoxidase (MPO) is an important metabolizing enzyme involved in oxidative stress response with some environmental carcinogens including benzene which is associated with bone marrow toxicity and leukemia after chronic exposure.
作者： 刊期： 2006年第03期
A total of 2402 patients of arseniasis in a few villages in Southwest Guizhou Autonomous Prefecture, China, represents a unique case of endemic arseniasis related with indoor combustion of high arsenic coal. This study aimed to investigate the possible involvement of hereditary factors in the risk modulation of arseniasis in two clans of different ethnic origin living in one village for generations.
作者： 刊期： 2006年第03期
Lead (Pb) is the heavy metal that has an effect on an irreversible mental retardation and brain development in newborn till the age of 2 year; therefore, World Health Organization has established a maximum allowance standard for blood lead in child at 10 μg·dL-1.
作者： 刊期： 2006年第03期
Pharmacogenomics was established on the fact that certain genetic polymorphisms may cause significantly different responses among individuals exposed to a particular drug. Single nucleotide polymorphism (SNP) is the most common form of genetic polymorphism in human genome.
作者： 刊期： 2006年第03期
Self-poisoning with pesticides is a major problem across the Asia Pacific region. Despite this there is little coordinated effort being applied to improve the medical response to this problem. Good clinical and supportive care is the cornerstone of management of the poisoned patient and in some situations will suffice even in the absence of a specific antidote.
作者： 刊期： 2006年第03期
Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. In order to examine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on agonist-induced vasorelaxation and vasoconstriction using the isolated rat aortic rings in in vitro organ bath system.
作者： 刊期： 2006年第03期
The no-observed-effect level (NOEL) in a study of carcinogenicity for compounds that are both genotoxic and carcinogenic represents the limit of detection in that bioassay, rather than an estimate of a possible threshold. Therefore, for those genotoxic and carcinogenic contaminants (e.g. acrylamides, PAHs, etc.) in foods it is not possible to develop health-based guidance values (e.g. ADI or PTWI) using the traditional NOEL and safety/uncertainty factors.
作者： 刊期： 2006年第03期
The aim is to investigate the health effects of depleted uranium(DU) material and the protective role of DMSO. Exposure model of rat was established by inhaling DU aerosol.
作者： 刊期： 2006年第03期
Dietary supplements need to show statistically sound evidence for the claimed health effect, and this often requires high dose of the material which in turn raises the safety concern regardless of whether it has been traditionally used or not, since it frequently exceeds the traditional use.
作者： 刊期： 2006年第03期
Persistent perfluorinated organic compounds, such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are used in a variety of industrial applications. They are very stable in the environment, distribute widely in the global environment and in wild life, and are detected in human sera.
作者： 刊期： 2006年第03期
Chemical allergy can take a variety of forms. Those of greatest relevance to toxicology are skin sensitisation resulting in allergic contact dermatitis, and sensitisation of the respiratory tract associated with allergic rhinitis and asthma. Both represent important health issues and there is a need for effective hazard characterisation and risk assessment.
作者： 刊期： 2006年第03期
Chemical hazards have been an object of public concern all over the world. The greatest problems are classified into two categories. One is environmental pollution. During the rapid industrialization of Japan, environmental pollution from industrial wastes produced many victims.
作者： 刊期： 2006年第03期
