中国浙江大学医学院第一附属医院旗下的国际肝胆胰疾病协会，发表了肝胆胰疾病领域临床实践与研究的同行评议论文、评论和社论。论文包括医学、外科、放射学、病理学、生物化学、生理和组织学方面的主题领域，包括肝脏、胆汁、胰腺、移植、研究、特别报告、社论、评论文章、简要报告、临床摘要、新的技术和临床图像。该期刊还涉及基础科学和实验工作。
应按照生物医学期刊投稿的统一要求，撰写包括随机试验、干预研究、筛查和诊断试验研究、队列研究、成本效益分析和病例对照研究在内的原始研究论文(www.icmje.org)。随机对照试验(rct)应遵循联合声明(www.consortium -statement.org)。其他文章的报告应遵循附录中列出的不同计划或小组所制定的准则。论文提交时，除通讯作者的姓名、地址、电话、传真号码或电子邮件地址外，还应提交两个单独的文件，其中一个文件应包含作者的详细信息和书名、短篇书名、作品来源。另一个文件应该只显示提交文章的标题、正在运行的标题、摘要、主要文本、表、图以及参考文献列表，这些将被发送给审稿人。
作者姓名(通常不超过6个)及其首字母的格式应与其他具有医学博士或博士等一项主要资格的出版物相同，并应与他们目前的职务和完整的邮寄地址相同。一名作家应以编辑函电命名。
每一篇论文都必须附有一份由所有作者签署的版权转让书(详见最后一节的详细描述)和其他相关文件，包括从研究对象处获得的知情同意以及从监管机构或机构伦理机构获得的研究批准。每份意见书的作者应阐明其研究的职能或贡献，并声明(如有)竞争利益。当决定接受这份文件时，将要求从下列声明中选择一项:
1. 作者或一名或多名作者已经或将从与本文主题直接或间接相关的商业方获得个人或专业使用的利益。
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作者选择的语句将随文章一起发表。每个作者的签名都是必须的。在肝胆胰疾病国际办公室收到完整的表格之前，任何文章都不会发表。
手稿应该有足够的页边距，在整个文本、参考文献和标题中，双行距是必不可少的。表、图、标题和引用列表应该正确地显示在文本中。样式应该简单直接，没有歧义和术语，尽量少使用缩写。
论文标题的选择要谨慎:篇幅短的文章影响更大，可以加上副标题。
原创文章的结构化摘要应包括背景、方法、结果和结论四个部分，篇幅不超过300字，总结文章中最重要的观点，并结合适合电子检索系统的关键词。
影响因子：指该期刊近两年文献的平均被引用率，即该期刊前两年论文在评价当年每篇论文被引用的平均次数
被引半衰期：衡量期刊老化速度快慢的一种指标，指某一期刊论文在某年被引用的全部次数中，较新的一半被引论文刊载的时间跨度
期刊发文量：通常是指在特定时间内，一个学术期刊所发表的论文数量。计算期刊发文量是评估期刊生产力和影响力的一个重要指标，也是学者选择投稿期刊时常常考虑的因素之一。
期刊他引率：期刊被他刊引用的次数占该刊总被引次数的比例用以测度某期刊学术交流的广度、专业面的宽窄以及学科的交叉程度
总被引频次：指该期刊自创刊以来所登载的全部论文在统计当年被引用的总次数。这是一个非常客观实际的评价指标，可以显示该期刊被使用和受重视的程度，以及在科学交流中的作用和地位。
平均引文率：在给定的时间内，期刊篇均参考文献量，用以测度期刊的平均引文水平，考察期刊吸收信息的能力以及科学交流程度的高低
BACKGROUND:?Pancreaticoduodenectomy? is? a? high? risk,?complex,? technically? challenging? operation? associated? with?signiifcant?perioperative?morbidity?and?mortality.?This?study?on?the?surgical?management?of?periampullary?cancer?patients?is?based?on?our?experience?in?a?period?of?nearly?13?years.METHODS:?The? study? was? conducted? on? two? groups? of?patients:?group?A?included?42?patients?who?were?treated?between?January?2000?and?September?2005?and?group?B?included?134?patients?who?were?treated?between?October?2005?to?October?2012.?Preoperative,?intraoperative?and?postoperative?details?of?all?these?patients?were?collected,?tabulated?and?analyzed?to?assess?the?impact?of?the?selective?approach?introduced?in?the?department?with?effect?from?October?2005.RESULTS:?Intraoperative? details? revealed? highly? signiifcant?differences?in?the?management?of?the?two?groups?of?patients?in?respect?of?operative?time?(250.4?vs?126.6?minutes;?P<0.001),?operative? blood? loss? (1070.2? vs? 414.9? mL;? P<0.001)? and?intraoperative?blood?transfusion?(1.4?vs?0.2?units;?P<0.001).?Variations? between? the? two? groups? in? the? frequency? of?complications? were? found? to? be? statistically? insigniifcant.?However,?the?difference?between?the?two?groups?in?the?overall?morbidity?of?patients?(47.6%?vs?26.1%;?P=0.009)?and?the?length?of?their?hospital?stay?(11.8?vs?7.8?days;?P<0.001)?were?signiifcant. CONCLUSION:?A?selective?approach?applied?to?the?surgical?management?of?periampullary?cancer?patients?is?a?step?in?the?right?direction.
作者： 刊期： 2014年第06期
BACKGROUND:?Ectopic?pancreatic?tissue?is?relatively?uncommon,?and?is?characterized?as?pancreatic?tissue?with?no?contact?with?the?normal?pancreas,?and?with?its?own?ductal?system?and?blood?supply.?It?is?usually?asymptomatic,?and?can?be?incidentally?diagnosed?by?conventional?imaging?studies. METHOD:?A? 69-year-old? woman? with? a? prior? history? of?bilateral?breast?carcinoma?presented?with?ectopic?pancreatic?intraepithelial?neoplasia?(PanIN)?that?was?identiifed?incidentally?in? the? small? bowel? during? an? oncological? resection? of? a?synchronous?primary?pancreatic?adenocarcinoma,?and?renal?cell?carcinoma. RESULTS:?The?patient?underwent?subtotal?pancreatectomy?with?splenectomy,?regional?lymphadenectomy,?radical?left?nephrectomy,?and?small?bowel?resection?with?primary?anastomosis?of?ectopic?PanIN-2.? She? had? an? uneventful? hospitalization? and? was?discharged?home?on?postoperative?day?7. CONCLUSIONS:?The?occurrence?of?ectopic?PanIN?is?extremely?unusual?with?only?few?cases?previously?reported?in?the?literature.?The?need?for?negative?margins?after?surgical?resection?of?ectopic?PanIN?lesions?remains?controversial.
作者： 刊期： 2014年第06期
BACKGROUND:?The?mitogen-activated?protein?kinases?(MAPKs)?signaling?pathway?is?involved?in?inflammatory?process.?However,?the?mechanism?is?not?clear.?The?present?study?was?to?investi-gate?the?role?of?p38?MAPK?in?acute?pancreatitis?in?mice.METHODS:?Mice?were?divided?into?4?groups:?saline?control;?acute? pancreatitis? induced? with? repeated? injections? of? ceru-lein;? control? plus? p38? MAPK? inhibitor? SB203580;? and? acute?pancreatitis?plus?SB203580.?The?pancreatic?histology,?pancre-atic?enzymes,?cytokines,?myeloperoxidase?activity,?p38?MAPK?and?heat?shock?protein?(HSP)?60?and?70?were?evaluated.RESULTS:?Repeated? injections? of? cerulein? resulted? in? acute?pancreatitis? in? mice,? accompanying? with? the? activation? of?p38? MAPK? and? overexpression? of? HSP60? and? HSP70? in? the?pancreatic?tissues.?Treatment?with?SB203580?significantly?in-hibited?the?activation?of?p38?MAPK,?and?furthermore,?inhib-ited?the?expression?of?HSP60?and?HSP70?in?the?pancreas,?the?inflammatory? cytokines? in? the? serum,? and? myeloperoxidase?activity?in?the?lung.CONCLUSION:?The?p38?MAPK?signaling?pathway?is?involved?in? the? regulation? of? inflammatory? response? and? the? expres-sion?of?HSP60?and?HSP70?in?acute?pancreatitis.
作者： 刊期： 2015年第01期
BACKGROUND:?Fibrolamellar? hepatocellular? carcinoma?(FLHCC)? is? a? rare? disease? with? an? indolent? behavior.? Its?prognosis?is?better?than?that?of?patients?with?hepatocellular?carcinoma.?The?authors?present?their?experience?with?resection?of?FLHCC.METHODS:?Twenty-one?patients?with?FLHCC?were?treated?at?our?institution?between?1990?and?2012.?Of?these?patients,?14?were?subjected?to?resection?of?the?tumor.?Patient?demographics,?medical?history,?results?of?imaging?studies?and?laboratory?tests,?surgical?data,?and?pathologic?ifndings?were?evaluated.RESULTS:?The?median?age?of?the?patients?at?the?diagnosis?of?the?tumor?was?20?years?and?14?patients?were?female.?None?of?the?patients?had?tumor-associated?chronic?liver?disease?or?cirrhosis.?The?mean?tumor?size?was?12.8?cm?(range?6-19)?and?18?patients?had?a?single?liver?nodule.?Fourteen?patients?were?subjected?to?hepatectomy?and?six?of?them?had?lymph?node?metastases?resected.?Pathologic?evaluation?revealed?that?5?(35.7%)?patients?had?major?vascular?invasion.?Tumor?recurrence?was?seen?in?8?patients?(66.7%),?during?a?follow-up.?The?median?survival?time?for?patients?who?were?subjected?to?resection?was?36?months.?The?5-year?overall?survival?rate?and?disease?free?survival?rate?were?28.0%?and?8.5%,?respectively.?Univariate?analysis?showed?that?vascular?invasion?was?the?only?variable?associated?with?the?disease?free?survival?rate.CONCLUSIONS:?Despite? an? aggressive? treatment,? patients?with?FLHCC?presented?unexpected?low?survival?rates.?It?seems?that?an?underestimated?malignant?behavior?is?attributed?to?this?disease,?and?that?the?forms?of?adjuvant?treatment?should?be?urgently?evaluated.
作者： 刊期： 2014年第06期
BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders, especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubMed search of Englishlanguage articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however, reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel?diseases?is?observed,?but?the?exact?role?of?these?enzymes?demands?further?studies.
作者： 刊期： 2014年第06期
BACKGROUND: Pancreaticobiliary maljunction is a high risk factor of pancreatitis and biliary tract cancer. How this mal-junction affects the liver remains obscure. This study aimed to examine the effects of pancreaticobiliary maljunction on the liver, pancreas and gallbladder in a cat model.METHODS: A model of choledocho-pancreatic side-to-side ductal anastomosis was created in ten cats.Before the procedure, a small piece of tissue from the liver, pancreas and gallbladder was collected as a control. The common channel formation was checked by cholecystography. The livers, pancreases and gall-bladders of these cats were harvested for histological examina-tion. The expression of proliferating cell nuclear antigen in the gallbladder was examined with immunohistochemistry.RESULTS: Seven of the 10 cats survived for 6 months after surgery. The color of the liver was darker in the PBM model than the control specimen, with nodules on the surface. His-tological examination showed ballooning changes and inflam-matory infiltrations and the histopathological score increased significantly (P<0.05). Also, mitochondria swelling and lipid droplet in cytoplasm were observed under an electron micro-scope. The pancreas also appeared darker in the PBM model than the control specimen and dilated pancreatic ducts were found in three cats. Histopathological examination revealed vascular proliferation and inflammatory infiltration with nu-merous neutrophils. Gallbladder epithelial cells were featured by expanded endoplasmic reticulum, increased intercellular space and cellular nucleus deformation. The positive cells of proliferating cell nuclear antigen were increased significantly (P<0.05).CONCLUSION: The present study demonstrated that pancreatico-biliary maljunction can lead to the injuries of the liver, pancreas and gallbladder.
作者： 刊期： 2015年第01期
作者： 刊期： 2015年第01期
BACKGROUND:?The?peripheral?morphologic?characteristics?of?hepatocellular?carcinoma?(HCC)?relfect?tumor?growth?patterns.?Computed?tomography?(CT)?perfusion?is?a?new?method?to?analyze?hemodynamic?changes?in?tissues.?We?assessed?the?relationship?between?CT?perfusion?and?histopathologic?ifndings?in?the?periphery?of?HCC?lesions.METHODS:?Non-contrast?CT,?enhanced?dual-phase?CT,?and?CT?perfusion?were?performed?on?77?subjects?(47?patients?and?30?controls).?Based?on?the?imaging?ifndings?of?enhanced?dual-phase?CT,?the?tumor?edges?were?classiifed?into?three?types:?type?I?(sharp);?type?II?(blurry);?and?type?III?(mixed).?The?CT?perfusion? parameters? included? hepatic? blood? lfow,? hepatic?arterial?fraction,?hepatic?arterial?perfusion,?and?hepatic?portal?perfusion.?The?tissue?sections?from?resected?specimens?were?subjected? to? routine? hematoxylin? and? eosin? staining? and?immunohistochemical? staining? for? CD34.? The? correlations?between?microvessel?density?(MVD)?and?the?CT?perfusion?parameters?were?analyzed?using?Pearson's?product-moment?correlation?coefifcient.?Changes?in?the?perfusion?parameters?in?tumor?edges?of?different?tumor?types?were?evaluated.RESULTS:?Type?I?(sharp):?the?pathologic?ifndings?showed?ifbrous?connective?tissue?capsules?in?the?tumor?edges,?and?an?MVD?≤?30/mm2.?Type?II?(blurry):?the?histology?showed?that?the?edges?were?clear?with?no?capsules?and?an?MVD?>30/mm2.?Type?III(mixed):?the?pathology?was?similar?to?that?of?types?I?and?II,?and?an?MVD?>30/mm2.?Hepatic?blood?lfow,?hepatic?arterial?fraction,?hepatic?arterial?perfusion,?and?hepatic?portal?perfusion?were?signiifcantly?increased?in?the?tumor?edges?of?HCC?patients?compared?to?those?of?the?controls?(P<0.05).?The?correlation?between?CT?perfusion?parameters?and?MVD?was?higher?in?blurry?tumor?edges?of?type?II?than?in?those?of?types?I?or?III.CONCLUSION:?CT?perfusion?imaging?of?tumor?edges?may?be?helpful?in?revealing?histopathological?features,?and?indirectly?relfect?angiogenic?changes?of?HCCs.
作者： 刊期： 2014年第06期
BACKGROUND:?At?the?time?of?diagnosis,?most?patients?with?gallbladder? cancer? are? in? advanced? stage? and? the? cancer? is?unresectable.?Long-term?survivors?are?usually?seen?in?a?small?number? of? patients? with? incidental? gallbladder? cancer.? This?study?aimed?to?identify?preoperative?predictors?of?incidental?gallbladder?cancer?in?elderly?patients.METHODS:?A?total?of?4014?patients?of?more?than?44?years?old?who?had?undergone?cholecystectomy?at?our?department?from?January?2000?to?December?2010?were?retrospectively?reviewed.?Univariate?and?multivariate?modalities?were?used?to?identify?the?predictive?factors?of?incidental?gallbladder?cancer.RESULTS:?Twenty-nine? of? the? 4014? patients? who? had? under-gone? cholecystectomy? for? benign? gallbladder? diseases? were?histologically?diagnosed?as?having?incidental?gallbladder?can-cer.?Multivariate?analysis?identified?that?elevated?carbohydrate?antigen? 19-9? combined? with? carcinoembryonic? antigen? and/or? carbohydrate? antigen? 125? (P=0.045),? a? gallbladder? polyp?greater?than?or?equal?to?1.2?cm?(P=0.043)?and?focal?gallblad-der?wall?thickening?of?more?than?or?equal?to?5?mm?(P=0.002)?were?predictive?factors?of?incidental?gallbladder?cancer.CONCLUSION:?Cholecystectomy? is? suggested? for? patients?with?these?predictive?factors?and?intraoperative?frozen?section?should?be?considered?to?rule?out?carcinoma.
作者： 刊期： 2015年第01期
作者： 刊期： 2014年第06期
退修了三四次，基本都是格式和缩减字数，可能文章比较符合期刊主题。样刊是平邮，大家一定要写好自己的详细地址，越细越好流泪
国际肝胆胰疾病（英文版）杂志 这个刊物免审稿费，版面费正常，效率高
国际肝胆胰疾病（英文版）杂志编辑的态度非常认真、和蔼，来回修改了好几次，很快就录用了。国内的顶级杂志，影响力很大，看来我的选择还是没有错的。给你们竖个大拇指。
急急，国际肝胆胰疾病（英文版）杂志 投稿要多长时间才能出结果，投了好久了，没见一点动静，有人告诉我么
先后投了两篇文章，审稿1个多月，直接退稿！搞不明白。。。
你好，请问国际肝胆胰疾病（英文版）杂志字数要求最高包括参考文献是多少字呢？是不加参考文献6000字以内呢？还是加上参考文献6000字以内呢？
国际肝胆胰疾病（英文版）杂志校稿认真负责，每次打电话都不厌其烦地回答我的不解之处。外审专家的审稿意见也很诚恳详细，对文章帮助很大！杂志质量还是挺不错的。
文章接收速度还可以，我投稿的时间有些尴尬，恰逢是在放假的时候，耽误了一段时间。国际肝胆胰疾病（英文版）杂志在学术界还是有一定地位，还是不错的。编辑老师也很不错，比较推荐大家投此杂志。
国际肝胆胰疾病（英文版）杂志在同类刊物里面相对比较容易中，审稿有回复，退稿有温度（笔者之前的文章因改动较大，杂志建议退稿之后修改重投），不失为一种选择
等了好几个月，终于收到书了，悬着的心终于放下了，感谢国际肝胆胰疾病（英文版）杂志编辑部大大，感谢~~感谢
