周进；王君
0 引言经颅多普勒( TCD)借助脉冲多普勒技术和 2 MHz频率超声波,经特定颅骨透声窗,直接描记脑血管多普勒信号,以获取脑动脉血流动力学参数,进而反应脑血管功能状态.
作者：李秀珍；史洪润；张国忠；姚勇；李新民；殷宇刚；韩恩吉 刊期： 2003年第01期
0 引言糖尿病性神经病变可累积全身多部位的神经如周围神经、植物神经、中枢神经、颅神经等,产生多种功能障碍如感觉障碍和运动障碍等,表现为疼痛、肢端感觉异常、痛觉过敏、发凉、步态不稳等.
作者：卢莹 刊期： 2003年第01期
目的:探讨高血压患者生活满意度和精神卫生状况间的关系.方法:以生活满意度调查表和SCL90为测量工具,对68例高血压患者进行对照研究和直线相关分析.结果:高血压患者生活满意度平均得分23.4,处于中等偏下水平,除居住和子女孝顺外与正常对照均有显著性差异(P<0.01).精神卫生状况除强迫和精神病性外与正常对照均有显著性差异(P<0.01).直线相关分析提示生活满意度低导致患者抑郁、焦虑、人际敏感和躯体化症状多.结论:高血压的发病与心理应激和生活满意度有关,家庭和睦、社会保障体系健全、良好的人际关系和经济状况,是减少应激和提高患者精神卫生状况的重要环节.
作者：苏景宽；王秉康；杨文清；郭克锋 刊期： 2003年第01期
针对高能聚焦超声在肿瘤治疗的应用过程中要解决的关键问题-成像、定位和聚焦及对关键问题常用的解决方法进行了简介,在进行比较的基础上选定了成像和聚焦解决方法;并在此基础上提出了一种高能聚焦超声肿瘤治疗仪的实现方案,对超声肿瘤治疗仪的关键部件治疗头部和臂部的结构结合实现功能进行了分析.分析了高能聚焦超声肿瘤治疗仪进行肿瘤治疗的过程:术前规划和手术模拟、术中定位和跟踪和术后治疗效果的评价.
作者：项林清；马培荪；陈亚珠；潘刚 刊期： 2003年第01期
Heat shock protein is a group of stress protein produced under ill state. It can protect normal cells from damages caused by bad stimulates. It is thought as one of substance basis that remain in the process of evolution and take effect of anti damage. Now it is paid attentions as neuron protective substance induced by cerebral ischemic preconditioning.
作者：许川山；余茜；吴士明；唐建民 刊期： 2003年第01期
目的:在氯化铝(AlCl3)所致拟痴呆动物模型基础上,探讨雌二醇对拟痴呆小鼠记忆功能保护作用及其作用机制.方法:皮下注射AlCl370mg/d共7d,实验组腹腔注射雌二醇0.3,0.6,0.9mg/kg共20d后,用跳台、避暗等实验方法测定小鼠学习记忆能力,同时测定小鼠脑内乙酰胆碱脂酶(AchE)及脑B型单胺氧化酶(MAOB)的含量.结果:AlCl3所致痴呆小鼠记忆能力明显降低,表现为避暗、跳台实验的错误次数明显增加,以及增加脑MAOB含量及脑内AchE的含量,雌二醇各剂量组能够减少小鼠电击次数(错误次数),24h重复实验,可延长跳下平台的潜伏期及进入暗箱的潜伏期,错误次数明显减少.同时降低了脑内AchE和MAOB.结论:雌二醇对AlCl3所致痴呆小鼠记忆障碍具有保护作用,能增强学习记忆能力.
作者：顾饶胜；沈楠；王艳春；吴晓东；刘微；都培双 刊期： 2003年第01期
目的:观察认知治疗对改善精神分裂症患者认识及部分行为能力.方法:将符合 CCMD 2 R精神分裂症诊断标准的患者 68例随机分为 A,B两组:分别采用精神药物配合认知治疗和精神药物配合支持性心理治疗.与入院 2, 4和 6周时作简明精神病评定量表 (BPRS)、护士用住院病人观察量表 (NOSIE)及服药依从性评定.结果:患者在入院两周时的 3项评定中,两组间均无显著性差异( P >0.05); 4周时评定 A组部分症状较 B组改善明显, 6周时评两组在 BPRS、 NOSIE及服药依从性方面均存有显著性差异( P< 0.05～0.01).结论:认知治疗在精神分裂症缓解期可提高患者对疾病的认识能力,改善部分行为障碍;对提高病人服药依从性、巩固疗效、防止复发有良好效果.
作者：王勇 刊期： 2003年第01期
AIM:To explore the membrane permeability, enzyme tolerance, and stability of phosphorothioate oligodeoxynucleotide(P ODN) which can inhibit cerebral thrombosis.METHODS:(1)Oligodeoxynucleotide was synthesized with phosphoramidite method in solid phase,3' end was modified with thiophosphoter.(2)Uptake and subcellular distribution of P ODN.P ODN was given directly.We observed total uptake rate of P ODN by ECV304 cells and subcellular distribution of P ODN.RESULTS:(1)ECV cells uptake more P ODN with increase of concentration,the uptake rate was about 10.8% - 11.9% .(2)Subcellular distribution of P ODN:P ODN was mainly distributed in nucleus especially nucleus sediments(69.3% - 77.2% )(P< 0.05).CONCLUSION:P ODN suppressing cerebral thrombosis has favorable transmembrane ability,enzyme resistance and stability.
作者：李黔宁；应大君；戴光明；郑健；王东武；肖道虹；刘勇；邓志宽；刘立杰；周永琴 刊期： 2003年第01期
BACKGROUND:Because disease course of stroke was long,directed nursing was undertaken to different mental and physiological manifestations to restore function at maximal degree and reduce incidence of disability.
作者：孙静敏 刊期： 2003年第01期
AIM:To evaluate the effectiveness of hospitalized occupational rehabilitation for chronic schizophrenic patients in social functioning.METHODS:79 qualified cases were selected from chronic psychiatric inpatient departments,divided into two groups randomly,of which 45 cases of treatment group accepted hospitalized occupational rehabilitation,another 34 cases of control group accepted ordinary treatment.Social functioning was evaluated by the Scale of Social Skills of Chronic Schizophrenic In patients(SSSI). RESULTS:6 month course of research figured out that the rank of improvement of the total disability degree of the treatment was significantly larger than that of the control group(P< 0.05).Items of which rank of improvement of the treatment was significantly larger than those of the control group are participating in the occupational rehabilitation,social withdraw and concern and care about others (P< 0.01- 0.05).The level of disability of 55.6% of the treatment decreased more than that of the control (26.5% ) (P< 0.05) evaluated by SSSI.CONCLUSION:Hospitalized occupational rehabilitation is effective in improving social functioning of chronic schizophrenic patients,especially in improving items like participating in the occupational rehabilitation, social withdraw and concern and care about others.
作者：卢苓；马胜民；翁永振；崔仁祥 刊期： 2003年第01期
0 引言短暂性脑缺血发作早期可用经颅多普勒 (TCD),脑电图 /彩色脑电地形图 (EEG/BEAM)进行诊断并监测脑血管血流变化情况,但二者所见对比,准确性如何,本文对此进行探讨.
作者：王顺华 刊期： 2003年第01期
AIM:To investigate the relationships between angiotensin converting enzyme gene polymorphism and lacunar infarction in patients with essential hypertension.METHODS:Polymerase chain reaction(PCR) was used to determine the genotypes for an insertion/deletion polymorphism of 287 pb fragment of ACE gene in 50 healthy persons,50 patients with simple essential hypertension and 30 patients with essential hypertension and lacunar infarction.RESULTS:There was no significant difference of genotype and allele between healthy persons and patients with simple essential hypertension;but there was significant difference of D allele and DD genotype of ACE gene between esential hypertensive patients with lacunar infarction and patients with simple essential hypertension and healthy persons.CONCLUSION:There is a significant relation between ACE gene polymorphism and essential hypertensive patients with lacunar infarction.
作者：徐岩；毛建华 刊期： 2003年第01期
BACKGROUND:It is considered now that early rehabilitation interventional mechanism is related to the plasticity of brain that means after injury of neural function,central nervous system has the ability of compensation and functional recombination.
作者：许艳芳；刘姝娜 刊期： 2003年第01期
BACKGROUND:Patients with mental disease gets into recovery stage after symptoms of acute phase are alleviated, returns to society and achieves clinical recovery.But some metal problems still exist in most patients that becomes an obstruction for patients to develop speciality and self realization.
作者：毛蕴；陈莉 刊期： 2003年第01期
BACKGROUND:The direction of modern research on rehabilitation is to recover the function,and improve patients' motion,living ability,make them turn round to family and society.
作者：谢淑丽；朱明光；张小丽 刊期： 2003年第01期
作者： 刊期： 2003年第01期
目的:观察垂体腺苷环化酶激活肽(pituitaryadenylatecyclaseactivatingpolypeptide,PACAP)对缺血再灌注脑神经元凋亡的防治作用.方法:利用四血管结扎法,建立老龄大鼠脑缺血再灌注模型,侧脑室注射PACAP,观察脑组织丙二醛(MDA)含量和超氧化物歧物酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)活性,计数海马CA1区存活和凋亡神经元数目,电镜观察神经元的超微结构变化.结果:PACAP治疗后脑组织MDA含量为(1.35±0.39)nmol/mg,SOD和GSHPx活性分别为(115±20)NU/mg、(10.3±2.0)U/mg,与缺血再灌注组有明显差异(P<0.05),海马CA1区存活和凋亡神经元数目为48.8±4.3,14.3±2.9,能促进神经元存活和减轻凋亡损伤(P<0.01),保护超微结构.结论:PACAP的保护作用可能与其降低脑组织氧自由基水平,提高抗氧化酶活性,防止神经元凋亡有关.
作者：刘宪霜；崔旭；王鲁宁；李文彬；韩志涛；尹志奎；房征宇 刊期： 2003年第01期
0 引言家庭和社会环境因素对精神疾病的发生发展,以及康复疗效的影响已日益受到精神病学家和康复工作者的重视 [1],精神病患者在社区康复过程中所受到的精神卫生服务质量如何?他们的家庭社会处境怎样?无疑与患者的康复预后密切相关.
作者：张仲荣 刊期： 2003年第01期
目的:通过2型糖尿病患者与正常对照者之间的比较,分析血清瘦素与多种影响因素的关系.方法:对样本人群进行流行病学问卷调查、体检并测定了血糖、血脂、胰岛素和血清瘦素等生化指标,通过病例对照研究方法加以分析.结果:2型糖尿病患者血清瘦素为(9.43±6.15)ng/ml,正常对照为(9.48±5.60)ng/ml.无论有无糖尿病肥胖者血清瘦素约是非肥胖者的2倍,女性约是男性的3倍.结论:2型糖尿病患者与正常对照者间的血清瘦素不存在显著性差异,可能与患者坚持治疗病情控制良好有关.血清瘦素受到吸烟、性别、体脂、血脂和饮食等多方面因素的共同影响,高密度脂蛋白胆固醇可能是其保护因素.
作者：谢娟；郭刚；来则民；张镜宇；木村美惠子 刊期： 2003年第01期
0 引言本文测定糖尿病患者骨形成生化标志血清骨钙素 (BGP)和骨密度,用以探讨糖尿病患者骨代谢改变的研究.
作者：于青琳；于庆潭 刊期： 2003年第01期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
