Professor XU Jian-zhong was born in a family of traditional Chinese doctor in Beijing, August, 1930. His native place is Putian, Fujian Province. Prof. XU has engaged for more than 40 years in clinical medicine since he was graduated from Shanxi Medical University in 1954. From 1958 to 1961, he was released from work to attend the TCM Learning Class for Doctors of Western Medicine for 3 years and granted the first grade prize by the Ministry of Health at graduation. Since then, the integration of traditional Chinese and western medicine (TCM-WM) has been the cause he devoted himself to. Now, he is Chief Doctor in Xiyuan Hospital, China Academy of Traditional Chinese Medicine, visiting professor of postgraduate education Department of China Academy of TCM, and Director of Specialty Committee of Respiratory Diseases, Chinese Association of Integration of Traditional and Western Medicine (CAIM).

作者： 刊期： 2001年第04期

To evaluate objectively the clinical effect and superiority of integrated traditional Chinese and western medicine (TCM-WM) in treating mid-late hepatocarcinoma.Methods: The 313 patients observed were divided randomly into 3 groups, Group Ⅰ, Ⅱ and Ⅲ, they were treated with protocol TACE, protocol PEI and comprehensive conservative therapy respectively. Each group was sub-divided into 2 sub-groups, sub-group A and B, and sub-group As was treated coordinately with different Chinese herbal medicine, Sisheng Decoction to sub-group ⅠA and ⅡA, and cinobufacin or norcantharidin to ⅢA respectively. And Chinese herbal medicine prescribed according to TCM Syndrome Differentiation was also given to all the sub-group As.Results: The integrated therapy showed significant effect in treating mid-late hepatocarcinoma, as it could improve significantly the clinical symptoms and signs, raise the quality of life and prolong the survival time in patients. When TCM-WM cooperated with TACE, it could alleviate the toxic effect and enhance the therapeutic effect of chemotherapy. There was statistical significant difference in clinical effect between the TCM-WM treated groups and the western medicine treated groups (P<0.05).Conclusion: TCM-WM therapy displays not only the action in enhancing the short-term therapeutic effect of treatment in treating mid-late hepatocarcinoma but also shows significant effect in enhancing long-term therapeutic effect and prolonging survival time in patients. It is worth further spreading.

作者：凌昌全；陈喆；朱德增；俞超芹；黄雪强；万旭英；李瑾；陈坚；沈峰；杨广顺；吴孟超 刊期： 2001年第04期

To study the dynamic changes and its clinical significance of integrated traditional Chinese and western medicine (TCM-WM) on IL-2 system, T cell and erythrocyte immune system in patients of lung cancer. Methods: Forty-eight patients with lung cancer were randomly divided into two groups: TCM-WM group (GroupⅠ) and the chemotherapy group(GroupⅡ). The relevant immune indices, clinical symptoms and signs, changes of solid tumor and quality of life were dynamically observed and compared with those in 20 healthy subjects for control. Results: The serum IL-2 level of lung cancer patients were originally significantly lower, while sIL-2R level higher than that of the healthy subjects. And they were raised and lowered respectively after treatment, especially in GroupⅠ, but still remained different from the control group yet. And there were highly negative correlation between IL-2 and sIL-2R levels. The percentage of CD3, CD4 and the CD4/CD8 ratio were decreased markedly in both groups. And the percentage of RBC-C3bRR was obviously lower, while that of RBC-ICR obviously higher. But the above-mentioned indices could be improved after treatment, especially in GroupⅠ, and there were highly positive correlation between CD4/CD8 ratio and RBC-C3bRR. However, in regard to the degree of improvement, the patients of GroupⅠ were in better position than those of Group Ⅱ. At the same time, improvement of their clinical symptoms and signs, change of entity tumor and quality of life of GroupⅠ all proved to be better than those of Group Ⅱ. Conclusion: The therapeutic superiority of TCM-WM on lung cancer may be related to the modulation on immune function. The effect of TCM-WM is better than that of chemotherapy alone.

作者：范国荣；宗文九；左劲夫；胡觉文；王晓玲 刊期： 2001年第04期

Source “Experienced Prescriptions of Ruizhu Tang (瑞竹堂经验方)” of Yuan Dynasty written by Shatu Musu (沙图穆苏）, published in 1326 A.D., it is a comprehensive prescription book about medicine, surgery, gynecology, pediatrics and sensory organs. Also carried in Chinese Pharmacopoeia (1995 edition).

作者： 刊期： 2001年第04期

According to the TCM theories of Meridian and Pulse-Picture, the author probed in the treatment of idiopathic thrombocytopenic purpura (ITP) with auriculo-acupoint pressing (AAP) and obtained good result. The study was reported as follows.METHODS General Materials Forty-five patients with chronic refractory of ITP selected from the 269 ITP in-patients, hospitalized from January 1991 to January 1998, were observed. They were diagnosed according to the clinical manifestations, peripheral blood picture and bone marrow examination, as well as platelet antibody test in some of them, which were all in accordance with the unified diagnostic standard of ITP in China(1). All of the patients had course of disease over half a year and their disease treated with hormone for 2-3 months ineffectively, and had hemorrhagic symptoms, such as dermatorrhagia and rhinorrhagia, with no hepatosplenomegaly, and platelet count within 8-72×109/L. The hormone therapy was withdrawn or stopped gradually in the observation period.

作者：卢燕 刊期： 2001年第04期

To observe the relationship between TCM Syndrome-type and insulin resistance (ISR) in coronary heart disease (CHD). Methods: Fifty patients were divided into 3 groups according to the Syndrome Differentiation-typing in TCM, the Heart blood stasis (HBS) Syndrome group, the Phlegm-Turbid stagnation (PTS) Syndrome group and both Qi-Yin Deficiency (QYD) Syndrome group. The fasting blood glucose (FBG), fasting blood insulin (Ins), insulin antibody (IAA), islet cell antibody (ICA), glutamic acid decarboxylase antibody (GAD-Ab) and related blood lipid parameters in patients were determined and insulin sensitive index (ISI) was calculated simultaneously. Then the above-mentioned data were compared with those determined in 20 healthy control subjects. Results: The levels of FBG and Ins in CHD group were higher than those in the healthy control group significantly (P＜0.05), but ISI level was obviously lower (P＜0.01). Moreover, the positive percentage of IAA (40%) was higher in CHD group than that in the control group (5%) significantly (P＜0.01). Comparison between the 3 TCM Syndrome-type groups and the control group showed that ISI level in HBS and PTS group was obviously lower than that in the control and the QYD (P＜0.05) respectively, and the IAA positive percentage in the former 2 groups (50%, 47.37%) was higher than that in the latter two (5%,P＜0.01 and 15.38%, P＜0.05) markedly. While Ins level increased only in the HBS group (P＜0.05). Besides, patients of HBS and PTS Syndrome were accompanied by lipid metabolic disturbance. Conclusion: ISR presents in part of CHD patients particularly in those with HBS and PTS Syndrome, which was partly due to the existence of serum IAA in patients.

作者：毛威；叶武；刘强；黄兆铨；陈申杰；秦南屏 刊期： 2001年第04期

To observe the leucocyte increasing effect of Shuanghuang Shengbai Granule (SHSBG) in tumor patients treated by chemotherapy and the bone marrow microenvironment protecting effect in mice.Methods: Patients of non-small-cell pulmonary, mammary, gastric or intestinal cancer, who were ready for receiving re-treatment of chemotherapy, were enrolled and divided into 4 groups randomly. The 28 cases in SHSBG group A received chemotherapy combined with SHSBG; the 27 in the SHSBG group B received chemotherapy alone at first, and SHSBG was added when their peripheral white blood cell (WBC) count lowered to ＜4×109/L; the 33 in control group A and 24 in control group B were treated by the method similar to that applied to SHSBG group A and B respectively but with Rubidate instead of SHSBG. Experimental study of electron microscopic observation on bone marrow ultrastructure in mice was also conducted.Results: The total leukocyte increasing effective rate occurred in SHSBG group A and B was 75.00% and 88.89%, while in control group A and B, 54.55% and 58.33% respectively, and the difference between the SHSBG groups and the control groups was significant (P<0.01). Experimental study showed that SHSBG has good bone marrow hematopoietic microenvironment protecting and improving effect in mice.Conclusion: SHSBG has obvious protecting and treating effect on chemotherapy induced bone marrow suppression in tumor patients.

作者：徐振晔；朱晏伟；周卫东；张晖；鞠艳芳；赵丽红；邓海滨；吴继；沈德义；张蕙心 刊期： 2001年第04期

To study the therapeutic effect of Chinese herbal medicine (CHM) combined with bronchial arterial chemotherapy (BAC) in treating lung cancer.Methods: Ninety patients with mid-advanced non-small cell lung cancer (NSCLC) were randomly divided into two groups. The 45 cases in Group A were treated with CHM combined with BAC and the 45 cases in Group B treated with BAC alone. The short-term and long-term effect, follow-up survival rate, quality of life, changes of clinical symptoms and peripheral blood figures in the patients were observed.Results: After treatment, the rate of CR+PR+NC in the two groups was 88.89% and 68.89% respectively, the inter-group comparison showed a significant difference (P<0.05). The 0.5-, 1- and 2-year survival rate in Group A was 75.56%, 55.56% and 48.89% respectively and in Group B 71.11%, 46.67% and 24.44% respectively. The 2-year survival rate in the former was better than that in the latter (P<0.05). Moreover, the improvement of clinical symptoms, Karnofsky scoring, body weight and peripheral blood figure in Group A was superior to those in Group B.Conclusion: Therapeutic effect of BAC could be enhanced by combining it with CHM.

作者：刘城林；王远东；金学军；刘丽萍；喻庆薇；蔡悦成 刊期： 2001年第04期

To observe the effects of Yifei Kangliu Yin(YFKLY) in treating non-small cell lung cancer (NSCLC). Methods:Two hundred and seventy-one patients with NSCLC were randomly divided into three groups, Group A treated only by YFKLY, Group B treated by the combination of YFKLY and chemotherapy, and Group C treated only by chemotherapy as the control group for control. Results: (1) Of the 127 cases in Group A, 1 case got complete remission (CR), 13 got partial remission (PR), 89 had no change (NC), and 24 had progression of disease (PD), thus CR+PR+NC accounting for 81.10%; of the 80 patients in Group B, 17 got PR , 53 got NC, 10 got PD, PR+NC accounting for 87.50%; of the 64 cases of chemotherapy group, 7 cases got PR, 39 cases got NC, 18 cases got PD, PR+NC accounting for 71.88% (P<0.01). (2) The metastasis rate was 23.52% in Group A, 20.00% in Group B and 35.71% in Group C respectively after treatment. (3) The 1-, 2-, 3- and 4-year survival rate were 73.09%, 32.01%, 13.18% and 13.18% in Group A, 71.85%, 46.35%, 29.19% and 23.35% in Group B and 37.61%, 13.67%, 9.7% and 0% in Group C. The symptoms were improved, and Karnofsky score was elevated in Group A and B. Conclusion: YFKLY could increase survival rate and quality of life, decrease metastasis rate, and enhance the immune function in NSCLC patients.

作者：刘嘉湘；施志明；李和根；徐振晔；朱晏伟；赵丽红；高虹；刘苓霜；朱惠蓉；张晖 刊期： 2001年第04期

Professor QIN Wan-zhang, born in August 1931 in Gaoyou, Jiangsu Province, graduated from Shanghai Medical University in 1957, and from Learning Class of Western Doctors in Traditional Chinese Medicine (TCM) sponsored by the State Ministry of Health in 1964. He has worked in Huashan Hospital and now is working for Zhongshan Hospital of Fudan University, Shanghai, successively holding the post of associate professor, professor, director and honorary president of the hospital. He is also Director of the Shanghai Medical Collaboration Center of Lupus Erythematosus for Integration of Traditional Chinese and Western Medicine (TCM-WM), Director of the Chinese Academy of Lupus Erythematosus, and the tutor of Successors for Shanghai’s Celebrated and Old Traditional Chinese Medical Specialists. He enjoys special allowance provided by the State Council.

作者： 刊期： 2001年第04期

To explore the relationship between the liver fibrosis criteria and TCM Syndrome type in patients suffering from non-alcoholic fatty liver. Methods: Seventy-nine patients with non-alcoholic fatty liver diagnosed by B ultrasonography were classified by TCM Syndrome Differentiation and their liver fibrosis criteria was determined and compared with those of the healthy subjects as control. Results: Levels of procollagen Ⅲ (PCⅢ), hyaluronic acid (HA), collagen Ⅳ(CⅣ) and laminin (LN) in the fatty liver group were significantly higher than those in the control group (P＜0.05, P＜0.01). In respect to the TCM Syndrome-types, PCⅢ, CⅣ and LN in patients of Phlegm-stasis combined type were significantly higher than those in patients of Spleen deficiency-Phlegm dampness Syndrome-type and Damp-Heat Syndrome-type (P＜0.05, P＜0.01), while HA in different groups was insignificantly different (P＞0.05). Conclusion: There was trend of liver fibrosis in fatty liver patients. It was indicated that the Phlegm-stasis combined Syndrome-type possibly was the main TCM pathologic factor of the increasing of fibrosis criteria for non-alcoholic fatty liver.

作者：邓银泉；范小芬 刊期： 2001年第04期

To observe the effect of Shenlong Oral Liquid（SLOL）combined with radiotherapy in treating nasopharyngeal carcinoma (NPC). Methods: Effects of the combined therapy, including clinical effects, changes of cellular immunity and side effects, in treating 60 NPC patients (in the treated group) were observed and compared with those of the other 60 patients treated with radiotherapy alone (in the control group). Results: (1)The side effects of radiation in the treated group were lower than those in the control group significantly (P＜0.05). (2) The short-term remission rate of nasopharyngeal and neck metastatic tumor in the two groups was not significantly different (P＞0.05). (3) The dose for complete remission of nasopharyngeal and neck tumor in the treated group was lower than that in the control group (P<0.01). (4) No change of T-lymphocyte subsets was found in the treated group after treatment, but in the control group , OKT3,OKT4,and OKT4/OKT8 ratio were markedly decreased (P＜0.05). (5) The survival rate in the treated group was higher than that in the control group, but with no statistical significance (P=0.0518). Conclusion: The combined therapy of NPC with SLOL and radiotherapy is able to reduce side-effect of radiotherapy, improve the cellular immunity, reduce the dose of radiation for tumor remission and enhance the therapeutic effect of radiotherapy. It showed a trend of raising the long-term survival rate of NPC patients.

作者：朱小东；王安宇；王绍丰；王仁生；陈龙；李龄；陆海杰 刊期： 2001年第04期

To observe the effect of radiotherapy (RT) combined with ginseng polysaccharide (GSP) injection in treating nasopharyngeal carcinoma (NPC) and its influence on immune function.Methods: One hundred and thirty-one patients of NPC were randomly divided into two groups, the RT-GSP group (n=64) treated with RT and GSP, and the control group (n=67) treated with conventional radiotherapy, to observe the local cancer remission rate, 1-year total survival rate, no tumor survival rate and no remote metastasis survival rate. Moreover, the changes of T-lymphocyte subsets, natural killer cell (NK) activity and lymphokine-activated killer cell (LAK) activity before and after treatment were determined.Results: Clinical examination conducted 3 months after treatment showed that the complete remission rate in the RT-GSP group was 96.6%, and in the control group 93.3%, the complete remission rate of cervical lymph node metastasis in the two groups was 85.7% and 78.0%, the NPC remission rate shown by CT 60.3% and 51.7%, respectively. Re-examination carried out 1 year after treatment showed that the total survival rate in the two groups was 100% and 96.5%, tumor free survival rate 84.4% and 74.6%, and no remote metastasis survival rate 93.8% and 88.1% respectively. The activity of NK cell and LAK cell as well as T3, T4 value in peripheral blood increased significantly in the RT-GSP group (all P<0.05) after treatment, while with the control group, no significant influence on NK and LAK activities were shown but significant lowering of T3, T4 was, P<0.05. No toxic-adverse reaction of GSP was found.Conclusion: GSP has certain immune function improving effect in NPC patients during RT, and it could also eliminate the occurred adverse reaction to RT and improve the general condition of patients.

作者：谢方云；曾智帆；黄惠英；赵充；卢泰祥 刊期： 2001年第04期

To elucidate the molecular mechanism on anti-arrhythmic function of Dingxin Recipe (DXR). Methods: Cardiac myocytes isolated by trypsin method were cultured and labeled with various fluorescence stains. DXR contained serum induced changes of cellular calcium concentration 〔Ca2＋〕i, cell membrane potential (MP) and mitochondria membrane potential (MMP) were determined with laser confocal microscopy. Results: Hypoxia caused increase of 〔Ca2＋〕i and MMP, and decrease of MP, while DXR contained serum lowered the 〔Ca2＋〕i in normal or hypoxic myocytes, improved hypoxia induced MP reduction and maintain MMP at baseline level under hypoxia circumstances. Conclusion: Through inhibiting the hypoxia caused 〔Ca2＋〕i and MMP elevation and MP lowering, DXR displays its action in protecting myocardial cells to prevent and treat arrhythmia.

作者：贾钰华；孙学刚；赵晓山 刊期： 2001年第04期

To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and explore its mechanism. Methods: MRL model mice were established by hypodermic inoculation with L7212 cells 1×106 following intraperitoneal injection of cytoxan (CTX) 250 mg/kg 3 days later, and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets, including CD3+, CD4+ and CD8+, and the survival time in model mice were observed. Results: Compared with the control, FZKBG could obviously increase both the percentage and absolute value of CD3+ and CD4+ lymphocytes and prolong the survival time of model mice, the prolongation rate being 29.6% - 60.4%. Conclusion: FZKBG could markedly prolong the survival time of MRL mice, and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.

作者：许勇钢；麻柔；胡乃平；刘锋；杨经敏；马玲；胡晓梅 刊期： 2001年第04期

From June 1995 to January 2000, 60 in-patients of middle-advanced hepatocarcinoma had been treated with two different methods and comparative study was conducted by the authors. Results showed that the better comprehensive effect was shown by the treatment of Aidi injection (ADI) combined with intervention chemotherapy. The study was reported in summary as follows.

作者：王晓红；刘玉茂 刊期： 2001年第04期

To study the therapeutic effect of Chinese herbal medicines (CHM) in treating ascites and to elucidate its mechanism in regulating the lymphatic stomata and promoting the absorption of ascites from the peritoneal cavity. Methods: Using scanning electron microscope (SEM), computerized image processing and quantitative analytic assay, the effect of CHM extract, consisting of Atractylodes macrocephala, Salvia miltiorrhiza, Codonopsis pilosula, Alismatis orientale and Leonurus heterophyllus, was studied. Results: Intraperitoneal injection of nitric oxide (NO) supplier (Sodium nitroprussiate) or CHM administration could cause the average area of lymphatic stomata obviously enlarged (P＜0.05), and the numbers of opening stomata significantly increased (P＜0.01) in normal healthy mice. When L-notroarginine, a NO synthetase suppressor, was injected after CHM administration, the regulating effect of CHM on lymphatic stomata was inverted obviously, i.e. the average area and the density of lymphatic stomata were markedly reduced (P＜0.01). Conclusion: CHM might treat ascites through increasing the endogenous NO concentration to open the lymphatic stomata and in turn to conduct the peritoneal water through lymphatic path.

作者：吴妤；李继承；毛连根；董晓巧 刊期： 2001年第04期

To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. Methods: Thirty-four patients with severe jaundice of acute icterohepatitis were treated with conventional western medicine and SCTH-1, the therapeutic effects were analyzed and compared with that in the control group (treated with western medicine alone). In the animal experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST in mice were monitored. Results: The markedly effective rate in the treated group and the control group was 73.5% and 59.1% respectively, and the effective rate was 23.5% and 40.9% respectively. The markedly effective rate in the treated group was obviously higher than that in the control group (P＜0.05). Experimental study showed that SCTH-1 could reduce the level of serum transaminase and liver tissue damage in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (P＜0.05). Conclusion: SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity and scavenging oxygen free radicals.

作者：连粤湘；龙晓英；吴婉芬；尹炽标 刊期： 2001年第04期

To explore the therapeutic effect and mechanism of Bushen Huoxue Xiezhuo Decoction (BHXD) in treating minute lesion nephropathy (MLN) in rats. Methods: The MLN model rats established by a single intravenous injection of Adriamycin were divided into the model and the BHXD groups, and a normal group was set up for control. The effects of treatment on renal function, hemorrheologic parameters, renal tissue transforming growth factor β1 (TGF-β1) expression and poly-anion sites on glomerular basement membrane were observed dynamically. Results: After treatment, all the parameters between the BHXD group and the model group were significantly different respectively, morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group. Conclusion: BHXD treatment could markedly improve the renal function, alleviate blood hypercoagulability and hyperviscosity, protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.

作者：张悦；魏民；王谦；楚非；严京；李伯光；贾旭 刊期： 2001年第04期

Date 22-24 Sept 2002(Sunday-Tuesday)Venue Beijing International Convention CenterSponsor Chinese Association of Integrative MedicineSupporters China Association for Science and Technology State Administration of Traditional Chinese Medicine, China State Drug Administration, China Development Center for Medical Science and Technology, Ministry of Health, ChinaCo-Sponsors China Academy of Traditional Chinese Medicine Chinese Academy of Medical Sciences China-Japan Friendship Hospital Medical Center of Peking University Beijing University of Traditional Chinese Medicine Hong Kong Huada Group Co. Ltd. Institute of Life Science and Engineering, Tsinghua University Modern Research Center of Chinese Medicine, Peking University Sanjiu Medical Trade Inc Ltd. Hong Kong Association for Health Care Hong Kong Association for Integration of Chinese-Western MedicineMain Themes

作者： 刊期： 2001年第04期