《中德临床肿瘤学杂志》2014年征稿启事

作者：《中德临床肿瘤学杂志》编辑部 刊期： 2014年第02期

Objective:The pathological complete response (pCR) rates of neoadjuvant chemotherapy (NAC) in triple-nega-tive breast cancer (TNBC) was reported higher than that in non-TNBC but ranged from 12%to 48%. pCR was reported to be a predictor of long overal survival and exact pCR rate of NAC in TNBC would give us some hints on how to improve outcomes of TNBC patients. The meta-analysis was conducted to estimate the pCR rate of NAC for TNBC through contrasting the pCR rates of TNBC and non-TNBC tumors in NAC. Methods:Studies were selected from the PubMed database and Cochrane Col aboration Library. pCR rates were col ected in groups of TNBC and non-TNBC tumors. Review Manager 4.2 was used to perform forest plots and funnel plots. Results:The analysis included 22 studies with 7168 patients, the aggregate pCR rate was 29.5%in TNBC group, which was 17.7%higher than non-TNBC. The summary relative risk (RR) for pCR rate of TNBC group with that of non-TNBC group was 2.55. No obvious statistical heterogeneity and publication bias was detected. Conclu-sion:This meta-analysis demonstrated that NAC showed a higher pCR rate in TNBC than non-TNBC.

作者： 刊期： 2014年第02期

Objective:The aim of our study was to measure and compare the serum hormone level of transplant group with blank control and castrated control groups after heterotopic autotransplantation of cryopreserved-thawed ovarian tissues into back muscles. Methods:A total of 40 SPF-SD female rats (5-6 week-old) were randomly divided into three groups:blank control group (group A), castration control group (group B) and transplant group (group C). Ovaries were removed by surgical procedure, then after cryopreservation and thawing procedures the ovarian tissues were implanted into the back muscles of mice in group C. After 4 weeks of ovarian tissues transplantation, al rats blood sampling were measured for E2, LH and FSH hormone levels by ELISA. Results:E2 level was significantly higher in group C and group A than group B [(38.98 ± 5.66) pg/mL, (8.14 ± 3.24) pg/mL;P<0.05) and [(36.30 ± 6.90) pg/mL, (8.14 ± 3.24) pg/mL;P<0.05)]. However, E2 level in group C and group A had no significant dif erence. FSH level in group B, group A and group C was (18.87 ± 2.54) nmol/L, (7.77 ± 0.87) nmol/L and (9.39 ± 2.12) nmol/L respectively. FSH level increased significantly in group B compared with group A, and the dif erence had statistical significance (P<0.05). FSH level was slightly increased in group C compared with group A, and the dif erence was not statistical y significant (P>0.05), but compared with group B, FSH level was significantly reduced and being statistical y significant (P<0.05). Conclusion:Autotransplantation of cryopreserved-thawed ovarian tissue into back muscles can sustain fol icular development and re-establish endogenous hormone production by restoring the factors such as angiogenesis and innervations at the graft site.

作者： 刊期： 2014年第02期

《The Chinese-German Journal of Clinical Oncology》诚聘审稿专家

《The Chinese-German Journal of Clinical Oncology (中德临床肿瘤学杂志)》是教育部主管、华中科技大学同济医学院主办的全英文国际性学术刊物。主要刊登肿瘤学领域的优秀科研成果和临床诊疗经验及基础理论研究方面的论文。

作者： 刊期： 2014年第02期

Objective:The aim of this study was to evaluate the ef ect of Jinlong capsule on the immune function for inter-vened patients with primary liver cancer. Methods:Matched the inclusion criteria, 60 patients were selected and randomly divided into two groups. The treatment group had 30 cases treated with Jinlong capsule combined with the transcatheter arterial chemoembolization (TACE);the control group had 30 cases treated with TACE. Each group was treated 30 days as a cycle, which had completed at least two cycles. Indicators of cellular immune function about the activity of CD3, CD4, CD8, CD4/CD8 and natural kil er (NK) cellwere detected before and after treatment, then to compare and analysis with each other. Results:Before treatment, the activity of peripheral blood CD3, CD4, CD8, CD4/CD8 and NK cellin the two groups was no significant dif erence (P>0.05);after treatment, the activity of CD3, CD4 and NK cellin the treatment group was significantly increased, the ratio of CD4/CD8 increased, and the value of CD8 decreased (P<0.05), the activity of CD3, CD4 and NK cellin the control group was significantly decreased, the ratio of CD4/CD8 decreased (P<0.05), and the value of CD8 slightly higher than before treatment (P>0.05), the dif erence between the two groups indicated the statistical significance (P<0.05). Incidence of gastrointestinal reactions, leucopenia, hemoglobin, platelet decline in the treatment group was lower than those in the control group, but without presenting the statistical significance (P>0.05). Conclusion:Jinlong capsule with hepatic arterial infusion chemotherapy can improve the patients’ immune function, and reduce the adverse reactions of interventional chemotherapy. Hence,it deserves to be promoted in clinical y.

作者： 刊期： 2014年第02期

Objective:The dosimetric characteristics for linear accelerators with the same model, and nominal energy are known to be very similar, as long as the machines are unaltered from the manufacturer’s original specifications. In this pre-liminary study, a quantitative investigation of the similarity in the basic photon and electron dosimetry data from the Siemens Oncor linear accelerators at our hospital (Children’s Cancer Hospital, Cairo, Egypt) was reported. Methods:The output factor (OF), wedge factors (WF), percentage depth dose (PDD), and beam profile for the 6 and 10 MV photon beams were measured. Results:The measured output factors varied by less than about 1%for each field size. The dif erence between the maximum and minimum PDD values at each depth was less than about 1%. The dif erence between the beam flattnes and symetry was no more than 1%at al of-axis distances. For electron the results showed that the PDD, OF, and the beam profiles were matched within 1%dif erences. Conclusion:These results strongly suggest that it is feasible to establish one reference photon and electron dosimetry data set for the two machines and nominal energies.

作者： 刊期： 2014年第02期

Objective:The aim of this study was to investigate the ef ect of grape proanthocyanidins (GPC) on the growth and angiogenesis of hepatocellular carcinoma H22 cells xenograft in mice. Methods:The xenograft model was established using injected subcutaneously H22 cells into the right axil a of the mice. Each group was treated with dif erent doses of GPC and Endostar. Al these treatments were maintained for 10 days, and mice were sacrificed. The xenograft tumors in mice were measured. The proliferation activity level of H22 cells was determined by MTT assay, and the levels of vascular endothelial growth factor (VEGF) protein were examined by immunohistochemistry. Results:When treated with 50, 100 and 200 mg/kg of GPC and Endostar, the tumor inhibition rates were 13.17%, 23.37%, 36.15%and 14.71%, respectively. The tumor weight of xenograft was significantly lighter in high GPC group than the control group (P<0.05). The ODs in GPC groups were 0.835, 0.666 and 0.519, respectively. The absorbances in middle and high GPC groups were statistical y significant, compared with control group (P<0.01). Immunohistochemical technique showed the expression of VEGF of the GPC groups was down-regulated significantly compared with the control group (P<0.01). Conclusion:GPC can inhibit the growth of hepatocellular carcinoma H22 cellxenograft in mice. The inhibition of angiogenesis by the down-regulation of VEGF expression may play a key role in the anti-neoplastic ef ect of GPC.

作者： 刊期： 2014年第02期

Objective:The aim of this study was to investigate the ef ect of toremifene on A549 human lung adenocarci-noma cells, and its sensibilization with gemcitabine, so that to provide a new clinical approach for non-smal-celllung cancer (NSCLC). Methods:A549 cells were seeded into 96-wel plates and exposed to dif erent agents (gemcitabine or gemcitabine with toremifene). The cytotoxicity of each agent was evaluated by MTT, cellcycle and apoptotic rate were detected by flow cytometry (FCM). Results:1. By using FCM, we found A549 cells in S and G2/M phases with toremifene decreased but increased in G0/G1 phase. The higher concentration of toremifene, the more decreased was when compared with the control group. 2. FCM showed toremifene’s apoptosis ef ect on A549 cells increased with its increasing dose. 3. By MTT, toremifene had no cytotoxic ef ect on A549 cells at the concentration of 5 or 2.5 μmol/L. The IC50 of gemcitabine to A549 was 34.51 μmol/L, and the combined group was 13.59 μmol/L. Conclusion:Toremifene could inhibit the growth of A549 human lung adenocarcinoma cells. Toremifene combined with gemcitabine showed significantly remarkable chemotherapy sensibilization on A549 human lung adenocarcinoma cells.

作者： 刊期： 2014年第02期

The adaptation and integration of imaging into the process of cancer detection, diagnosis, and intervention is an area of medicine that is undergoing extremely rapid development. Radiation therapy is a prime example of this change. While the objectives of these developments are clear, they raise numerous issues regarding the skil s and resources that assure these technologies are appropriately integrated and applied. We wil explore the basic concepts related to image guidance in various radiotherapy-related procedures with special emphasis on the clinical potentials of this impressive technology.

作者： 刊期： 2014年第02期

Objective:The aim of this study was to investigate the impact of beta-elemene injection on the growth and beta-tubulin of human hepatocarcinoma HepG2 cells. Methods:cellproliferation was assessed by MTT assay. cellcycle distribution was detected by flow cytometry (FCM). The mRNA expression of beta-tubulin was measured by RT-PCR. West-ern blot analysis was used to determine protein expression of beta-tubulin and the polymerization of beta-tubulin. Results:Beta-elemene injection inhibited HepG2 cells proliferation in a dose-and time-dependent manner;FCM analysis indicated beta-elemene injection induced cellcycle arrested at S phase. RT-PCR and western-blot analysis showed that beta-elemene injection down-regulated beta-tubulin expression at both mRNA and protein levels, presenting a dose-dependent manner. Moreover, beta-elemene injection reduced the polymerization of microtubules in a dose-dependent manner. Conclusion:Beta-elemene injection can inhibit the proliferation of hepatoma HepG2 cells, the mechanism might be partly related to the down-regulation of beta-tubulin and inhibition of microtubular polymerization.

作者： 刊期： 2014年第02期