脑源性神经营养因子抗体对大脑中动脉阻塞大鼠缺血损伤的影响

陈英辉；王根发；陈兴华；姚革；陈伟；周永炜

关键词：brain-derived neurotrophic factor, Cerebral Ischemia, microinjections

摘要：AIM:To observe the effect of the antibody of brain derived neurotrophic factor(BDNF) by cortical microinjection on hippocampal ischemic injury rats.METHODS:Preparation of local cerebral ischemic reperfusion injury model: cortical stereostaxic approach, microinjection of BDNF antibody. Applied immunohistochemical method to observe distribution of BDNF in cortex after injection of the antibody,to observe the alteration of ischemic injury between control group and BDNF antibody group.RESULT: The volume of cerebral infarction in BDNF antibody group was larger than control group.CONCLUSION: BDNF has protection function for cerebral ischemia.

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