中国生物医学工程学报（英文版）杂志

In order to listen to brain activity as a piece of music, we proposed a scale-free brainwave music (SFBM) technology, which translates the scalp EEG into music notes according to the power law of both EEG and music. In this paper, the methodology was further extended to chorus music of two channels from the two hemispheres. Firstly, EEG data from two channels symmetrically located on the left and right hemispheres are translated into MIDI sequences by SFBM, respectively, where the EEG parameters modulate the pitch, duration and volume of each music note. Then, the two sequences are fiitered into a chorus of the Chinese pentatonic scale or the Western major scale. The resulted Chinese and Western music at different sleep stages illustrate distinct differences in harmony, and the music with Chinese pentatonic scale sounds more harmonious.

作者： 刊期： 2014年第03期

Objective: To analyze the heart rate variability in Chinese PLA navy global visiting task group. Methods:We analyzed the heart rate variability in Holter in 77 men and 4 women for 5-15 days before voyage, and 65-75 and 115-125 days after voyage, and 29 men and 3 women for 5-15 days after having finished voyage. Results:NN50 and VLF were lower in 77 men and 4 women for 65-75 days after voyage than that was 5-15 days before voyage (P<0.01). SDANN was lower in 77 men and 4 women for 115-125 days after voyage than that was 65-75 days after voyage (P<0.01). SDNN, SDANN, SDNN index, RMSSD, NN50, PNN50,Triangular index, VLF, HLF, VAI and VLI were lower in 77 men and 4 women for 65-75 days after voyage than that was 5-15 days before voyage (P<0.01).Conclusion: These findings suggest that voyage may reduce heart rate variability for a long time.

作者： 刊期： 2014年第01期

作者： 刊期： 2014年第01期

The dielectric properties in vitro present characteristic changes along with the alteration of metabolic activities, which can be detected from tissue micro-structure. The dielectric properties of tissues are closely related to its viability, but the relationship remains unclear to us. This study aims to specify the relationship between dielectric parameters and microstructure of living tissues and to try to explain the influence of tissue viability on dielectric properties. Nine rabbits were studied in this experiment. The impedance spectroscopy (10 Hz-1 MHz) and microstructure were determined at different time intervals (from 5 min to 7 h) after samples were prepared. Some characteristic parameters were extracted to analyze the relationship between them. The inactivation process characterized by the microstructurs could be detected by means of dielectric parameters:the microstructures had no obvious change within 30 min and cell swelling caused by osmosis led to the decrease of extracellular ion concentration, resulting in the rise of lowfrequency imped ance after 30 min. The reduction of impedance was accompanied by the expanding intercellular area and irregular cell shape caused by the gradual destruction of cell membrane.The functions between alteration rate of intercellular area and Cole-Cole model parameters were also established. There is a strong correlative relationship between dielectric properties and microstructure. The dielectric spectrum can be a rapid and innocuous method to monitor the status of tissues. In the future, it may be of great help for clinical application, especially in transplantation.

作者： 刊期： 2014年第02期

The conventional bypass design is to implant a graft on the stenosed host artery allowing blood to flow bypass the stenotic artery. However, restenosis is a challenging problem which finally results in reoperation. The purpose of this paper is to propose a new bypass graft design of coronary artery with an assistant graft for the treatment of coronary artery stenosis. An additional assistant graft was employed in the new design compared with the conventional ETS anastomosis. Numerical simulations were performed by means of finite volume method using computational fluid dynamics (CFD) solver. Results demonstrated that the new anastomoses model provided a more smooth flow at the distal ETS anastomosis without any stagnation point on anastomotic bed and vortex formation in the heel region. Oscillatory shear index (OSI) and time-averaged wall shear stress gradient (TAWSSG) at the artery bed of the distal ETS anastomosis were reduced. The coronary artery bypass graft with an assistant graft is feasible to improve the local hemodynamics and diminish the probability of restenosis in the treatment of coronary artery stenosis.

作者： 刊期： 2014年第01期

作者： 刊期： 2015年第01期

To effectively suppress white noise and preserve more useful components of electrocardiogram (ECG) signal, a novel de-noising method based on morphological component analysis (MCA) is proposed. MCA is a method which allows us to separate features contained in an original signal when these features present different morphological aspects. According to the features of ECG, we used the UWT dictionary to sparsely represent mutated component, and used the DCT dictionary to sparsely represent smooth component. The experimental results of the samples choosing from MIT-BIH databases show that the MCA-based method is effective for white noise removal.

作者： 刊期： 2014年第01期

Parasporins(PSs) represent a novel functional category of crystal proteins (Cry) produced by non-insecticidal Bacillus thuringiensisA distinct feature for PSs is their specific cytotoxicity against human cancer cells from diverse origins, other than hemolytic or insecticidal activityAs structurally/functionally Cry proteins, parasporins are expressed as protoxins that require protease cleavage for activationCurrently, identified PSs is classified into 6 groups:PS1, PS2, PS3, PS4, PS5 and PS6, which are heterogeneous in cytotoxic spectrum and activity levelSome PSs have been explored for their mode of anticancer activities, reports mainly include pore formation induced by binding to putative receptors on cell membrane and apoptosis by intracellular Ca 2+concentrationFurther work should focus on the identification of new PS or PS homologs and better understanding of their anticancer mechanism before possible application in cancer therapy.

作者： 刊期： 2015年第01期

Objective: This study aims to explore the association between the density of Himalayan marmot (Marmota himalayana) and climatic factors such as temperature, precipitation, humidity, vapour pressure, sunshine percentage, wind velocity, which are closely associated with global climate change, and to provide a reference for plague prevention and control. Methods: We conducted a regression analysis to find the possible climate factors associated with the density of Himalaya marmot, and analyzed the response characters of Himalayan marmot to climate change. Results:Daily precipitation days (>=0.1 mm) and sunshine percentage were significantly associated with the density of Himalayan marmot ( p<0.01). Conclusion:Climate change was associated with the risk of plague. This phenomenon is valuable for Himalayan marmot and plague prevention. More studies are needed to understand the impact of climate change on Himalayan marmot and plague.

作者： 刊期： 2014年第02期

作者： 刊期： 2015年第01期