认识路易体痴呆

脑电图与经颅多普勒对脑梗死后癫痫的评估价值

INTRODUCTION Cerebrovascualr disease is common disease of senile nerve system, and is also main reason to epilepsy. Handicapping rate of cerebral stroke is high. There was few report on EEG and TCD of epilepsy after stroke.

作者：麦训良；叶小红；林玉兰 刊期： 2003年第07期

血管内皮生长因子和第VIII因子相关抗原在脑出血大鼠脑内的表达

AIM:To observe the expression of vascular endothelial growth factor(VEGF) and Factor VIII related antigen(FVIII- R Ag) in rats brain tissue in the border zone of the hematoma,and explore the relationship between the expression of VEGF and the brain angionesis after intracerebral hmorrhage(ICH). METHODS:Rat of model of ICH was induced by injection of collagenase physiological saline into the right caudate nucleus.The immunohistochemical methods were performed by using different antisera of VEGF and FVIII- R Ag in serial sections of rats brain at 12 h,1 d,3 d and 7 d after ICH respectively.RESULTS:The amount of VEGF positive cells was markedly increased,and reached the highest at 7th day in the border zone after ICG(P< 0.01),but there were no significant difference among the mean value of A of cells at different time points (P >0.05).Compared with the controls,both the FVIII- R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH goups after 1 day.CONCLUSION:The upregulated expression of VEGF might induce proliferation of endothelial cell and angiogenesis in the border zone after ICH in rats.

作者：揣兰香；张微微；戴卫平 刊期： 2003年第07期

遗传性脊髓小脑共济失调7型的临床研究

目的遗传性脊髓小脑共济失调 7型( SCA7)是 SCA系列中首个确定累及视网膜的疾病,该研究探讨中国 SCA7的临床特点.方法对一个表现为视力下降、辩色力异常和共济失调的 SCA7家系 23例成员( 8例患者)进行了系统的家系调查、体格检查及头颅 MR、眼底照相、视觉诱发电位、视网膜电流图等有关的辅助检查,结合国内外文献总结 SCA7临床特点.结果该家系为常染色体显性遗传,多数患者视力损害先于共济失调,存在视网膜色素变性 , 为蓝-黄色盲或蓝色盲,无夜盲,无智能减退.结论中国 SCA7患者临床表型存在多样性.

作者：韩燕；郑惠民；丁素菊；蒋建明；余龙；黄兴华；马丽杰 刊期： 2003年第07期

高龄重度心功能不全患者的护理评估

INTRODUCTION Severe heart failure threatens people's health,especially old patients.Nursing assessment for patients with congestive heart failure is an important premise for improvement of nursing quality.

作者：王霞 刊期： 2003年第07期

早期心理干预对脑卒中偏瘫患者心理健康的影响

AIM:To observe the influence of psychological intervention on mental health of hemiplegias after stroke.METHODS:82 hemiplegias after stroke were divided into control and intervention groups in certain conditions.Patients in control group received only routine treatment,while patients in intervention group received psychological intervention as well.Symptom Checklist was adopted to measure the mental health of patients.RESULTS:The scores of panic,anxiety,depression and stubborn in intervention group were significantly lower than that in control(P< 0.05 or P< 0.01). CONCLUSION:Early psychological intervention can improve the mental health of hemiplegias after stroke.

作者：谢淑丽；朱明光；崔焕波；刘海燕 刊期： 2003年第07期

早期康复护理对脑卒中患者日常生活能力的影响

INTRODUCTION Recently,death rate of stroke acute stage decreased dramatically due to improvement of diagnosis,salvage and treatment in cerebral vascular.However,mutilation rate increased.In order to relieve disable and improve ability of daily life in stroke patients,early rehabilitation care should be taken in acute stroke patients to get better effects.

作者：逄桂英 刊期： 2003年第07期

电生理检测对贝耳麻痹患者的预后评估

AIM:To estimate the prognosis of Bell palsy.METHODS: Blink reflex (BR), electromyography(EMG),motor latency(ML) and amplitude (AMP) of facial nerve were performed in 42 patients with Bell's palsy.The patients were followed about half a year.RESULTS: (1)When 1 of the 3R waves related with the ill side existed or appeared in 3 weeks after onset,97% patients could recover completely.The recovery time was related to the time of the occurrence of R wave.(2) When 1 of the 3 R waves appeared in the 4th week, 60% patients could recover completely.When none of the 3 waves appeared after the 4th week,100% patients could not recover completely.EMG showed spontaneous activities in 3 of the 6 patients in the 4th week.(3) Motor latency and amplitude of facial nerve were examined when the illness stopped developing.All patients had normal latencies.5 patients' amplitudes reduced more than 90% . 3 of the 5 patients did not appear the related R waves after the 4th week.CONCLUSION:BR might provide the early sign of good prognosis of Bell's palsy. BR together with EMG and ML and AMP of facial nerve might provide the later sign of poor prognosis.

作者：鲍海平；常宇；毛艺芳；尹琳；高政 刊期： 2003年第07期

上海地区帕金森病基因与4种多巴胺递质代谢相关基因

目的:探讨 4种多巴胺递质相关基因 COMT, DBH, DAT1 和 MAOB的多态性与上海地区居民帕金森氏病的易感性的关系.方法:用聚合酶链式反应和限制性片段长度多态性( PCR/RFLP)技术检测 4种多巴胺能递质代谢相关基因多态性,对 144名原发性帕金森病病人和年龄相匹配的 188名健康人进行相关性分析.结果:与健康人相比,帕金森病患者 DBH 基因型或等位基因的分布不同,两组之间的差异有统计学意义.结论: DBH多态性在中国汉族人帕金森氏病的易感性中可能起作用.

作者：赵晓萍；谢惠君；汤国梅；赵武伟；徐玲；林大宇；朱琪泉；苏敬敬；韩海雄；郝怡鑫；兰和魁；王荫榆；任大明 刊期： 2003年第07期

亚低温治疗重型颅脑损伤失败17例分析

INTRODUCTION Subhypothermic treatment is the most effective method for treatment of severe cranial injury and its application in clinic in recent years has achieved good effect.But some difficulties still need further exporation.

作者：张锦宏；王兴鹏 刊期： 2003年第07期

医用红外热像图反映周围神经病的冷激发试验

INTRODUCTION At present,ultrasonic doppler is used to examine blood circulation in big vessels in clinic,but there isn't still good and simple method for examination of blood circulation and vascular functions of limbs end and infrared thermography has some advantage in this aspect.It is well known that Raynaud phenomenon is caused by spasm and lesion of small end vessels of limbs.In clinic,provocation test might be used to provoke its onset and acknowledge of reaction condition of provocation in healthy people is the premise to judge abnormality and other lesions.

作者：张志强；苑秀华；沈艺莲；李少忠；俞澄；田丽君 刊期： 2003年第07期

老年人用药心理误区及心理康复

INTRODUCTION In the medical service for people accepting resting therapy and senile cadres,some psychological misunderstanding of medication of the aged often are observed.Meantime,the problem of reasonable medication more and more cause attention of people.

作者：刘家寿；李秀琴；陈丽萍；林宏燕 刊期： 2003年第07期

老年脑梗死患者血清同型半胱氨酸水平及药物干预研究

目的了解正常人颈动脉硬化患者及脑梗死患者血清同型半胱氨酸 (serum total nomocysteine,tHcy)水平及给予叶酸和维生素 B12治疗后血 tHcy含量的变化.方法脑梗死组 80例,男 71例,女 9例,年龄 63～ 80岁,平均 74岁,符合脑梗死的诊断标准,均在发病后 2周内测定 tHcy含量;颈动脉硬化组 80例,男 71例,女 9例,年龄 62～ 79岁,平均 72岁.双侧颈动脉 B超检查均存在颈动脉硬化及 (或 )粥样斑块.以上两组均除外甲状腺功能减退及肾功能减退.入选者在测定血清叶酸、维生素 B12、肌酐、血糖、血脂水平及血压和体重指数后,各组均随机分为两组,即干预治疗组及非干预治疗组,每组 40例.干预治疗组患者给予叶酸 1.25 mg,隔日 1次,维生素 B12 8 μ g, 1次 /d,口服 10个月后复查上述各项指标.结果治疗前 3组血 tHcy水平各不相同,脑梗死组为 (16± 5) μ mol/L,颈动脉硬化组为 (14± 5) μ mol/L,正常老年人组为 (12± 3) μ mol/L, 3组比较差异有显著意义.血 tHcy含量增高,叶酸水平越低.相关分析发现,血 tHcy水平与叶酸、维生素 B12呈负相关.干预治疗后,治疗组患者的血 tHcy含量均有所下降.结论不同程度的脑缺血性疾病与血 tHcy水平有一定的关系,补充营养元素有助于降低血 tHcy水平,以减少高 tHcy对血管的素性作用.

作者：黄延焱；卢晓喆；程梅芬 刊期： 2003年第07期

亚力克对大鼠定量脑电图及海马神经细胞的影响

目的 ALEC(亚力克 )是由α-亚麻酸( A)、 L-赖氨酸( L)、维生素 E( E)及维生素 C( C)组成的复方,通过正交试验设计,以脑组织中乳酸含量为指标,确定 4者比例( A: L: E: C为 432: 187: 18: 8) ,研究 ALEC对大鼠在局限性缺血、缺氧状态下的脑细胞保护作用.方法用定量方法分析在体皮层脑电( ECoG)在正常供气与停止呼吸情况下的变化,采用电凝阻断一侧中动脉造成局限性脑缺血模型及判断药物的脑保护作用.结果 ALEC高、中、低 3个剂量组均能延长大鼠急性反复性缺氧皮层脑电消失 /振幅达低时间,缩短脑电恢复时间.ALEC可减少大鼠大脑中动脉梗死( MCAO) 24 h后海马 CA1区细胞死亡数.结论 ALEC对脑细胞具有保护作用.

作者：潘建春；宋培贞；库宝善 刊期： 2003年第07期

鲍海平硕士·副教授

作者： 刊期： 2003年第07期

溶栓治疗后辅以物理因子对下肢深静脉血栓的效应

INTRODUCTION The objective of resist coagulating treatment is prevent a spread of thrombus and new thrombus form, hasten a connect again of vein and in same is an assistant treatment for dissolve thrombus and operation.It is the first way presently that dissolve thrombus cure DVT.

作者：金辉；胡中；杨斌；金勇 刊期： 2003年第07期

综合疗法对脑外伤的康复作用

INTRODUCTION Cerebral trauma is a kind of injury of skull and brain induced by out force struck.Except the direct injury of skull and cerebral tissue, secondary injury such as intercranium hematom,cerebral edema and increased intracranial pressure always occurred.Sometimes,with compliance of fracture of cervical vertebra and spinal cord,peripheral nerve injury.If synthetic rehabilitation methods were used, good effect can be detected.

作者：唐梅 刊期： 2003年第07期

人工阴道对阴道直肠癌术后患者性功能恢复的作用

BACKGROUND:Under the prerequisit of radical cure modern treatment of tumor need keep or rebuild functions of patients and improve their quality of life during the period of suvival.

作者：丁仕章；何玉芳；张镇平 刊期： 2003年第07期

康复护理在社区老年人慢性病医疗中的作用

INTRODUCTION With aging of population structure and small- size of family structure the need of senile patients on long- term rehabilitation serves increases,which greatly improve and propel the development of rehabilitation nursing of senile people in domain of nursing speciality. The assessment of need of senile people on long- term nursing and knowing about available service items of senile nursing of community and on what extent the items satisfying providing massage and foundation for senile nursing are urgently needed from the levels of body, psychology and social support through social investigation,which also can provide reference about plan and policy for managers of senile health serve system.

作者：苗文哲；姜万梅；赵薇；姜艳滨 刊期： 2003年第07期

星状神经节阻滞改善肩手综合征的水肿及关节活动度

INTRODUCTION:Shoulder- hand syndrome(SHS) also called reflective sympathetic malnutrition is a common syndrome and often seen in stroke paralysis,which early manifestation is sudden edema of hand,pain,increased skin temperature,shoulder pain.If treatment is prolonged,muscle atrophy of hand and permanent loss of range of movement might occure.Comprehensive rehabilitation treatment has a good effect on SHS.In this article,effect of block of ganglion stellatum on SHS is observed on base of comprehensive rehabilitation treatment.

作者：曾西；陈尚康；关晨霞；姜丽；王留根 刊期： 2003年第07期

半胱氨酸蛋白酶抑制剂对大鼠脑缺血模型DNA损伤的实验研究

目的研究 caspase- 3抑制剂 Ac- DEVD- CMK及 calpain抑制剂 ALLN干预治疗对大鼠局灶性脑缺血 /再灌注模型的神经保护作用.方法经左侧侧脑室注射 DEVD或 /和 ALLN及溶剂二甲基亚砜( DMSO)后,制作大鼠左侧 MCA缺血再灌注模型;缺血 2 h再灌注 24 h进行 TTC染色观察梗死灶的形成情况;并分别于缺血 2 h再灌注 24 h或 48 h检测鼠脑中单、双链 DNA断裂情况.结果溶剂 DMSO预处理组的各项指标与 MCAO模型组无明显差异; DEVD或 ALLN治疗后缺血侧脑中 Klenow及 TUNEL阳性细胞数均明显减少,二者合用作用强.结论 Caspase- 3与 calpain均在缺血性脑损伤中起重要作用,对此进行治疗干预具有潜在的临床应用价值.

作者：王宇卉；卞杰勇；强华；夏春林；邵福源 刊期： 2003年第07期