This research uses alginate and hyaluronic acid as the main component to prepare support, then explores the possibilities as a tissue engineering scaffold. Firstly, prepare HA with various average molecular weight and alginate with different viscosity, mix them up at a certain proportion and make it into a AlgCa 2+-HA composite scaffold with a film-forming method. This article discusses the feasibility of this scaffold used in tissue engineering field according to the consequence of moisture content testing, mechanical analysis, and scanning electron microscopy analysis. The structure and properties of AlgCa2+-HA composite scaffold are closely related to some factors such as average molecular weight of hyaluronic acid, hyaluronic acid concentration, alginate viscosity, cross-linking agents and processing technology. The AlgCa 2+-HA composite material, which is at different proportions and adding different cross-linking agent,has some certain characteristics:moisture content ranging from 50%to 95%, tensile strength between 2.69 N/mm2 and 4.299 N/mm2, and elongation at break is about 58%to 160%. The prepared AlgCa2+-HA composite scaffolds can be used as tissue engineering scaffolds resulting from its high moisture content, good mechanical properties and ideal pore structure.
作者: 刊期: 2014年第03期
In order to listen to brain activity as a piece of music, we proposed a scale-free brainwave music (SFBM) technology, which translates the scalp EEG into music notes according to the power law of both EEG and music. In this paper, the methodology was further extended to chorus music of two channels from the two hemispheres. Firstly, EEG data from two channels symmetrically located on the left and right hemispheres are translated into MIDI sequences by SFBM, respectively, where the EEG parameters modulate the pitch, duration and volume of each music note. Then, the two sequences are fiitered into a chorus of the Chinese pentatonic scale or the Western major scale. The resulted Chinese and Western music at different sleep stages illustrate distinct differences in harmony, and the music with Chinese pentatonic scale sounds more harmonious.
作者: 刊期: 2014年第03期
Immobilization using little splint is an original innovation of Chinese people for the fracture fixation, which is simple to use and clinically effective. It was found that Chinese immobilization using little splint can make the non-invasive, uncovering, and trouble free healing of bone fracture via harmonious unity of the structure stability and the force balance, of the motion stability and the stress adaptability, of the constant and discontinuous physiological stress. The biomechanical effect of Chinese immobilization using little splint, including entirety, dynamic, and functional fixity, is the root cause of its inheritance and the use up to now, and also is a direction of today's fracture fixation towards personalization, individuality and entirety.
作者: 刊期: 2014年第03期
How to design clinical trials for medical devices is a problem plaguing the industry today. As there are many differences in clinical trials of medical devices and drugs. This paper describes the differences of the two points from the perspectivs of defi-nition of medical devices and drugs, scope, phasing, subjects and design of clinical trials in details, aiming to help the related personnel make scientific decisions while conduct-ing clinical trial design for medical devices.
作者: 刊期: 2014年第03期
To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2 ±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.
作者: 刊期: 2014年第03期