Cellular Engineering in Cell Biology

摘要：The behavior of leukocyte-surface interaction is studied in lught of its important robe in the infalammatory process and in the development of ovtificial organs associated with prolonged blood contact. The process of cell-surface interaction revolves around a complex balance of forces arising from hemodynamic shearing effect and the strength of adhesive bonds between cell and substrate.This balance depends strongly on cell deformability and the expression of cell adhesion molecules (CAMs).In the course of these studies,a novel side-view flow chamber system has been developed to examine leukocyte(white blood cell)deformation and adhesion to various surfaces (cultured vascular endothelium,reconstituted purified CAMs,or biomaterials )under flow conditions that simulate the in vivo envronment.