王玲；张薇；惠延平
BACKGROUND:In China,steroid such as dexamethasone was often used for curing multiple sclerosis(MS),which had definitive effect but was slow in effect and needed a long time for taking medicine,more importantly,had severe side- effect.In recent years,high dose methylprednisolone has achieved some effect on immuno- neurologic diseases.
作者：陈运平；孙圣刚；梅元武 刊期： 2003年第07期
目的神经干细胞体外培养的成功是进一步研究其分化机制的基础 ,从胚胎大鼠脑室下区分离、培养、鉴定神经干细胞 (neural stem cells,NSCs),并观察其向神经元的分化情况.方法分离胚胎 SD大鼠脑室下区的组织,采用无血清原代及传代培养方法,获得具有克隆能力的细胞群;应用免疫细胞化学方法鉴定神经干细胞并检测分化后特异性成熟神经细胞抗原的表达;应用流式细胞检测技术观测神经干细胞随时间向神经元的分化情况.结果从胚胎大鼠脑室下区分离培养的细胞群具有克隆增殖能力,表达神经上皮干细胞蛋白( nestin),分化后的细胞表达神经元、星形胶质细胞和少突胶质细胞的特异性抗原;随着贴壁后分化时间的延长,表达 nestin的细胞数量从 80.5%下降到 10.9%,而神经元特异性烯醇化酶( neuron specific enolase,NSE)阳性细胞数量则从 1.1%上升到 31.6%.结论用本方法分离的细胞具有自我更新和增殖能力,并具有多分化潜能,是中枢神经系统的干细胞;随着分化时间的延长,神经干细胞数量下降,而神经元比例有明显上升.
作者：张瑞国；万琪；李力；俞英欣；曹云新 刊期： 2003年第07期
INTRODUCTION Poems dyndrom is a kind of rarely seen clinical symptomes with multiple system impairment,including polyneuropathy, swelling of organs,endocrine disorder,M protein and skin lesions.Other symptoms including anasarca,profuse sweating,hippocratic nails and low febrile.
作者：陈玮；锁海虹；赵琳；王桂荣 刊期： 2003年第07期
目的制作一种新的猫脑损伤后持续性植物状态模型,观察其临床特征.方法将 40只猫行硬膜外水囊置放术,然后向水囊内注入无菌水直到昏迷,并对动物模型进行评估.结果手术 1个月后,有 12只猫处于植物状态,动物模型的临床表现、体征等与持续性植物状态患者相近.结论本实验制作的持续性植物状态动物模型与临床患者相似,是一种比较理想的持续性植物状态动物模型.
作者：肖华；徐如祥；李金彩 刊期： 2003年第07期
BACKGROUND:Temporomandibular disorders ( TMD) included a group of clinical symptoms and disorder of masticate muscle group and temporomandibular joint,while its causes are not clear.TMD is characterized by pain around temporomandibular joi nt,sanp,and movement disorder in mandible,Currently,it is generally accepted that multiple factors resulted in TMD,including mental and psychological,muscular and tooth factors.Comprehensive treatment rather than single treatment is suggested for TMD.
作者：黄昊红；徐文华；李佐强；韩永红 刊期： 2003年第07期
AIM:To observe the expression of vascular endothelial growth factor(VEGF) and Factor VIII related antigen(FVIII- R Ag) in rats brain tissue in the border zone of the hematoma,and explore the relationship between the expression of VEGF and the brain angionesis after intracerebral hmorrhage(ICH). METHODS:Rat of model of ICH was induced by injection of collagenase physiological saline into the right caudate nucleus.The immunohistochemical methods were performed by using different antisera of VEGF and FVIII- R Ag in serial sections of rats brain at 12 h,1 d,3 d and 7 d after ICH respectively.RESULTS:The amount of VEGF positive cells was markedly increased,and reached the highest at 7th day in the border zone after ICG(P< 0.01),but there were no significant difference among the mean value of A of cells at different time points (P >0.05).Compared with the controls,both the FVIII- R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH goups after 1 day.CONCLUSION:The upregulated expression of VEGF might induce proliferation of endothelial cell and angiogenesis in the border zone after ICH in rats.
作者：揣兰香；张微微；戴卫平 刊期： 2003年第07期
INTRODUCTION Xingding is a compound agent of the fourth edition extract of ginkgo leaf,with addtion of agacore.Its main ingradient are ginkgo seed flavonoid glycoside(24% ), ginkgo seed lactone(3% ),bilobalide(3% ) and agacore(10% ).With ginkgo leaf acid smaller than 5× 10- 6,many clinical and basic research prove it has many biological effects.
作者：雷显泽；周妮；黄良国 刊期： 2003年第07期
BACKGROUND:Post stroke depression(PSD) directly affects quality of life and neural rehabilitation.Effect of traditional Chinese medicine is favorable.
作者：王凤起；董晓瑞；潘云霞；刘敏 刊期： 2003年第07期
INTRODUCTION Bed score is formed due to continuous compression on local tissues and poor blood circulation.Local tissues were ischemia,anoxia and nutritious metabolism disorder and degeneration occurred.Because of low immunology function, poor nutritious status and hyperglycemia of diabetes patients,specificity of skin was increased to stimulations. Once injured, the wound is difficult to heal and thus care is difficult,as well.
作者：于淑英；赵敏；徐书卉 刊期： 2003年第07期
AIM:To investigate the efficacy of huperzine A in treating child language delay and its side effects.METHODS:37 children with language delay and other developmental diseases from pediatric neurology out- patient department, who did not undergo any language rehabilitation,were treated with huperzine A 50 μ g bi- daily for more 3 months and then the efficacy and side effects observed.The follow- up was arranged to record the efficacy monthly.RESULTS:37 cases of 40 had undergone the whole course and the total efficiency was 68% (25/37). Language developments of other 12 cases were not improved significantly.Other 3 children were not included in because epilepsy were observed among them.CONCLUSION:This pilot trial result suggests that huperzine A has efficacy on child language delay but should be investigated further.Huperzine A may trigger seizure of language delay patients with epilepsy.
作者：廖建湘；陈黎；黄铁栓；李冰 刊期： 2003年第07期
BACKGROUND:Children cerebral palsy not only affects the quality of the affected children's lives but also burdens the family and the society heavily.Therefore, analysis of the disease and its causes from the viewpoint of clinic might helpful in treatment and prevention of the disease.
作者：赵蒙 刊期： 2003年第07期
目的研究 caspase- 3抑制剂 Ac- DEVD- CMK及 calpain抑制剂 ALLN干预治疗对大鼠局灶性脑缺血 /再灌注模型的神经保护作用.方法经左侧侧脑室注射 DEVD或 /和 ALLN及溶剂二甲基亚砜( DMSO)后,制作大鼠左侧 MCA缺血再灌注模型;缺血 2 h再灌注 24 h进行 TTC染色观察梗死灶的形成情况;并分别于缺血 2 h再灌注 24 h或 48 h检测鼠脑中单、双链 DNA断裂情况.结果溶剂 DMSO预处理组的各项指标与 MCAO模型组无明显差异; DEVD或 ALLN治疗后缺血侧脑中 Klenow及 TUNEL阳性细胞数均明显减少,二者合用作用强.结论 Caspase- 3与 calpain均在缺血性脑损伤中起重要作用,对此进行治疗干预具有潜在的临床应用价值.
作者：王宇卉；卞杰勇；强华；夏春林；邵福源 刊期： 2003年第07期
丘脑出血是脑卒中的一种类型 , 丘脑卒中后肩痛严重影响脑卒中患者的情绪及功能恢复.为探讨磁疗治疗丘脑出血后肩痛疗效,应用磁疗方法治疗丘脑出血后肩痛患者 11例 ,均取得明显疗效 ,提示磁疗法对改善丘脑出血后肩痛有效.
作者：王旭 刊期： 2003年第07期
INTRODUCTION Before the growth and development of brain,or before or after birth, if the brain was injured by damage or injury,permanet,partial or all of the extremeties may harbor motor or positional abnormorlites. This kind of the abnormality is changed with the development of the infant.At the same time,there were different problems and priority development points at different growth stage and can be classified as infant age, school age and puberty age.
作者：王育庆；段俊峰；施凤玲 刊期： 2003年第07期
目的探讨功能磁共振 (blood oxygenation level dependent functional MRI, BOLD fMRI)在临床医学方面的应用价值.方法对 1例右侧顶叶单发转移瘤患者在手术前、后分别进行了双侧动手试验的脑功能成像.结果脑功能成像准确地反映了运动功能激活区的位置及激活程度,肿瘤侧运动区可因肿瘤占位效应产生移位,手术前的手动试验潜在功能区并未被激活,但是在肿瘤切除术后,主运动区 M1以外可见潜在重组的功能区激活.结论脑内重要功能区肿瘤切除术患者,应常规进行术前和术后 fMRI的研究,这对于提高术后患者生活质量、避免医源性损伤或将其减至低水平有极大的帮助.
作者：张磊；金真；曾亚伟；王彦；郑冬；续元超 刊期： 2003年第07期
脑损害患者存在的语义范畴特异性损伤现象激发了人们对语义知识神经表征规则的研究.传统的神经心理学检查法及功能成像技术是研究语义记忆神经基础的主要方法.神经心理学是通过研究患者脑损伤部位与其损伤的语义知识范畴间的关系来推断语义知识的神经基础;而功能成像技术是通过直接检测正常人在提取各范畴语义知识时的脑活动模式来揭示语义知识的神经基础.因此,作为语义记忆探测材料的认知任务的设置直接影响到研究的效度与结果.因各研究所用的认知任务不同,研究结果与结论也呈现出较大的分歧,部分学者认为语义记忆是一单一的统一体,但部分学者认为语义记忆是一由类别子系统或是通道子系统组成的集合体.
作者：金花；莫雷；陈卓铭 刊期： 2003年第07期
目的研究新生大鼠缺氧缺血时脑内血红素氧化酶- 1( HO- 1)和内源性一氧化碳( CO)及环化鸟苷酸( cGMP)的变化,探讨锌原卟啉( Znpp)的治疗作用.方法 7 d SD大鼠随机分为假手术对照组,缺氧缺血组( HI)及缺氧缺血+锌原卟啉组( HI+ Znpp).利用分光光度法测定血 COHb含量和脑匀浆 HO- 1活性;放免法测定脑匀浆 cGMP水平,并观察脑病理改变.结果 HI组在 1, 4, 12 h HO- 1、 cGMP、 CO水平与对照组比明显升高( P< 0.01),在 12 h达到高峰; HI+ Znpp组 HO- 1、 cGMP、 CO水平在 1, 4, 12 h均明显低于 HI组( P< 0.01),但仍高于对照组( P< 0.01).脑组织病理检查可见 HI组呈重度缺氧缺血改变,多数神经元细胞肿胀变性;而 Znpp组神经元变性者少.结论 HI后脑内 HO- 1活性明显增高导致内源性 CO和 cGMP增高, Znpp可阻抑这一病理生理过程,减轻脑损伤.
作者：王玲；张薇；惠延平 刊期： 2003年第07期
作者： 刊期： 2003年第07期
INTRODUCTION Postcranial- trauma headache is one of the most common symptoms in clinic.The earlier these symptoms are improved the more active effects will be obtained for the patients' recovery and prognosis. `
作者：杜安民；万从容 刊期： 2003年第07期
BACKGROUND:Magnetopolarization quantum blood QOG treatment means using auto- venous blood or other people's blood of same type 150 to 200 ml and transferring back to body after external anticoagulation.
作者：张谦；郑世文 刊期： 2003年第07期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
