陈运平；孙圣刚；梅元武
INTRODUCTION Before the growth and development of brain,or before or after birth, if the brain was injured by damage or injury,permanet,partial or all of the extremeties may harbor motor or positional abnormorlites. This kind of the abnormality is changed with the development of the infant.At the same time,there were different problems and priority development points at different growth stage and can be classified as infant age, school age and puberty age.
作者：王育庆；段俊峰；施凤玲 刊期： 2003年第07期
INTRODUCTION Hiccups is autonomic intermittent contraction of Diaphragm.It is thought as a kind of nerve reflex action, and can be cured spontaneously or after treatment.But refractory hiccups isn't easy to cure because of long duration, frequent onset and severe degree.
作者：邓炳海；迟振海；王桂梅；张超；李爱民 刊期： 2003年第07期
BACKGROUND:During the therapy of cencers,it is difficult to continue chemiotherapy due to frequent vomiting,especially commonly used drugs such as side effects of cisplatin.Although new pharmacy appeared in greatly relieve vomiting effect of the chemiotherapy, there were no satisfied drugs to settle this problem.
作者：王中华；陈冬波 刊期： 2003年第07期
INTRODUCTION It is reported 70%- 90% patients show dementia psychology and behavior in patients with aging dementia (AD),which are the main causes of hospitalization.Others can not understand AD patients who also can not understand the other persons affecting quality of nursing.So,to comprehend communication skills,to support them menally are very important for improvement of AD patients' quality of life.
作者：欧正红；黄丽葵；卢玉贞；孔容冰；马超 刊期： 2003年第07期
AIM:To evaluate the diagnosis value of MRI for neurovascular compression (NVC) in trigeminal neuralgia(TN) and facial spasm(FS).METHODS:15 patients with TN and 2 patient with FS underwent SE T1WI and T2WI first, then 3D- TOF- SPGR sequences.RESULTS:NVC was found in all the patients, MRI findings were consistent with the surgical operative findings completely.CONCLUSION:It is considered to be of important to use MRI to find out the causes of TN and FS,especially to utilize the 3D- TOF- SPGR sequences, which may possess high sensitivity in determining NVC.
作者：公茂青；佟志勇；李喆；王运杰 刊期： 2003年第07期
INTRODUCTION Peripheral nerve lesion resulting from drug toxicity is caused by drugs which interrupt some enzymes in process of nervous metabolism and lead to loss of myelin sheath or axis- cylinder degeneration. Some drugs used in clinic can lead to peripheral nerve lesion. Patients showed symptoms such as numbness, asthenia.
作者：张昆林；马莎；毛小川 刊期： 2003年第07期
INTRODUCTION Brain injury is a common trauma which sequela causes severe influence on patient.In recent ten years,there are many reports about study of rehabilitation treatment on severe brain injury and results of most studies suggest that rehabilitation has obvious effect,rehabilitation at different degrees is achieved and therapeutic results are improved.
作者：王兴鹏；张锦宏；杨国瑞 刊期： 2003年第07期
AIM:To observe the expression of vascular endothelial growth factor(VEGF) and Factor VIII related antigen(FVIII- R Ag) in rats brain tissue in the border zone of the hematoma,and explore the relationship between the expression of VEGF and the brain angionesis after intracerebral hmorrhage(ICH). METHODS:Rat of model of ICH was induced by injection of collagenase physiological saline into the right caudate nucleus.The immunohistochemical methods were performed by using different antisera of VEGF and FVIII- R Ag in serial sections of rats brain at 12 h,1 d,3 d and 7 d after ICH respectively.RESULTS:The amount of VEGF positive cells was markedly increased,and reached the highest at 7th day in the border zone after ICG(P< 0.01),but there were no significant difference among the mean value of A of cells at different time points (P >0.05).Compared with the controls,both the FVIII- R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH goups after 1 day.CONCLUSION:The upregulated expression of VEGF might induce proliferation of endothelial cell and angiogenesis in the border zone after ICH in rats.
作者：揣兰香；张微微；戴卫平 刊期： 2003年第07期
AIM:Abnormal transparent septum is common in clinical works but little in meaning,so some CT reports are not listed.We collected complete abnormal transparent septum cases to perform comparison analysis between CT diagnosis and clinical data.METHODS:109 abnormal transparent septum diagnosed by CT was compared with symptom of clinics.Axis scanning and no enhanced scanning were used in CT and 2 doctors in charge of sample collection.The 109 cases were excluded with abnormal transparent septum induced by secondary local cerebral atrophy and secondary perforation deformity.RESULTS:There were 15 cases with the fifth ventricle of cerebrum and 22 cases with the fifth and sixth ventricle of cerebrums,10 cases with transparent septum cyst,28 cases with translocation of transparent septum,8 cases with no crack in the forebrain,6 cases with poor development of keratoma and 20 cases of other deformity.CONCLUSION:Abnormal transparent septum cannot be omitted and should be clearly diagnosed by CT.
作者：曹连义；张勇 刊期： 2003年第07期
目的研究急性脑血管病( acute cerebrovascular disease,ACVD)患者的职业、家庭经济收入对其记忆功能的影响.方法用修订韦氏记忆量表( WMS)检测 120例 ACVD患者的记忆功能.结果 ACVD患者的 WMS各量表粗分、量表分和 MQ值明显低于对照组;工人、农民的 WMS各量表粗分、量表分和 MQ值明显低于干部和科技工作者,其异常率则明显高于干部和科技工作人员;家庭人均收入与 WMS粗分、量表分和 MQ呈明显正相关( r=0.21～ 0.51),大多数量表分、总量表分和 MQ均表现为小于或等于 500～ 799元组明显低于大于 500～ 799元组.阳性率则仅小于 300元组明显高于 800～ 1 199元组.结论 ACVD患者瞬时、短时、长时记忆均明显损害;工人、农民的 3种记忆损害均较干部、科技工作者重;家庭人均收入少于和等于 500～ 799元者各项记忆损害亦大于 500～ 799元者;干部、科技工作职业、较高家庭收入对记忆功能损害有保护作用.
作者：王琳；高唱；周红杰 刊期： 2003年第07期
INTRODUCTION At present,ultrasonic doppler is used to examine blood circulation in big vessels in clinic,but there isn't still good and simple method for examination of blood circulation and vascular functions of limbs end and infrared thermography has some advantage in this aspect.It is well known that Raynaud phenomenon is caused by spasm and lesion of small end vessels of limbs.In clinic,provocation test might be used to provoke its onset and acknowledge of reaction condition of provocation in healthy people is the premise to judge abnormality and other lesions.
作者：张志强；苑秀华；沈艺莲；李少忠；俞澄；田丽君 刊期： 2003年第07期
目的探讨功能磁共振 (blood oxygenation level dependent functional MRI, BOLD fMRI)在临床医学方面的应用价值.方法对 1例右侧顶叶单发转移瘤患者在手术前、后分别进行了双侧动手试验的脑功能成像.结果脑功能成像准确地反映了运动功能激活区的位置及激活程度,肿瘤侧运动区可因肿瘤占位效应产生移位,手术前的手动试验潜在功能区并未被激活,但是在肿瘤切除术后,主运动区 M1以外可见潜在重组的功能区激活.结论脑内重要功能区肿瘤切除术患者,应常规进行术前和术后 fMRI的研究,这对于提高术后患者生活质量、避免医源性损伤或将其减至低水平有极大的帮助.
作者：张磊；金真；曾亚伟；王彦；郑冬；续元超 刊期： 2003年第07期
INTRODUCTION Subhypothermic treatment is the most effective method for treatment of severe cranial injury and its application in clinic in recent years has achieved good effect.But some difficulties still need further exporation.
作者：张锦宏；王兴鹏 刊期： 2003年第07期
作者： 刊期： 2003年第07期
缝隙连接( gap junction, GJ)是相邻细胞间直接交流胞质成分进行通讯的唯一通道.中枢神经系统神经元间 GJ通讯涉及许多生理及病理的过程,其通道的开-关与神经损伤的修复、癫痫的发作、记忆的形成与再现、肌痉挛的发生等均密切相关.因此,通过了解调节 GJ开-关的诸多因素,阻止神经元损伤的扩延,在神经功能重建时期,开放 GJ通讯促进神经元的重塑具有重要的临床意义.
作者：蒋晓江；李书林 刊期： 2003年第07期
目的探讨亚甲基四氢叶酸还原酶( methylene tetrahydrofolate reductase,MTHFR)基因 C677T多态性与脑梗死的关系.方法采用 PCR- RFLP技术,检测了 62例脑梗死患者和 79例对照者的 C677T突变的基因型.结果 MTHFR基因 C677T 突变型等位基因 (V)频率在患者组和对照组,差异有显著性意义 (χ 2=4.41, P< 0.05); 3种基因型频率在两组人群中差异均无显著性意义.基因型频率的相对危险分析, AV基因型比 AA基因型患脑梗死危险高 1.76倍; VV基因型比 AA基因型患脑梗死危险高 3.25倍.结论 MTHFR基因 C677T突变型等位基因与脑梗死有一定的关联,突变基因型增加了脑梗死的发病危险.
作者：赵永波；王乔树；王枫；郭春妮 刊期： 2003年第07期
INTRODUCTION People have paid great attention to how to elevate curative effects and decrease relapse of severe cardiac insufficiency patients in rehabilitation stage.Foreign researches showed that specific health education can enhance patients' self- care ability,ameliorate prognosis and decrease relapse.Our research tried to elevate rehabilitation nurse quality of senile patients through rehabilitation guide of senile severe cardiac insufficiency patients in recovery stage.
作者：罗仕兰；江洁 刊期： 2003年第07期
对于前庭系统性眩晕,仅靠临床表现来判断病变部位有无器质性损害,容易出差错.应用神经电生理检查,显示电生理改变,是否对临床医生有指导作用?为此,对前庭系统性眩晕患者进行脑干听觉诱电位( BAEP)检测,结合影像学资料及住院观察其转归情况,分析 BAEP的临床应用价值.
作者：吴振东；周宏君；李壮丰；陈汉波 刊期： 2003年第07期
目的探讨单纤维肌电图 (SFEMG)在糖尿病周围神经病 (DPN)中的应用.方法 2型糖尿病患者 36例,采用 Viking IV肌电图仪,测定指总伸肌的颤抖和纤维密度 (FD),同时进行常规神经传导检测 (NCS)并测量空腹血糖和糖化血红蛋白 (HbA1c).结果颤抖和 FD具有相关性,且均与 HbA1c呈正相关.18例 NCS异常者,颤抖值均超出正常范围 (11例伴阻滞 ), 14例 FD增加; 18例 NCS正常者, 7例颤抖值增大 (3例伴阻滞 ), 5例 FD增加.结论颤抖和 FD所反映的失神经-神经再支配与代谢状况相关联; SFEMG是 DPN早期诊断的敏感手段,可发现亚临床神经病.
作者：王真真；陈文明；卢祖能；王镇涛；曾庆杏；聂传云 刊期： 2003年第07期
目的观察大鼠永久性大脑中动脉阻塞( pMCAO)后,相应区域 DNA断裂损伤情况,探讨 DNA单链损伤在 pMCAO所致脑组织损伤中的意义.方法采用常规 HE组织染色明确大鼠 pMCAO模型成功与否及其损伤范围,采用 DNA聚合酶- 1 Klenow片段原位杂交方法检测 pMCAO不同时间点 DNA单链断裂损伤情况.结果损伤区域单链 DNA断裂的 Klenow阳性细胞在 pMCAO后 6 h即有表达( P< 0.01),在 24 h时达到高峰( P< 0.01), 72 h时有所下降( P< 0.01).结论单链 DNA断裂损伤在 pMCAO后 6 h即可出现,并逐渐积累,成为缺血半暗带内细胞损伤发展过程的重要环节,并可能预示半暗带损伤范围的不断扩大.
作者：万琪；张巍；刘勇红 刊期： 2003年第07期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
