Objective:To study the modulation effect of Blu-ray irradiation combined with comprehensive treatment on serum indicators of neonates with hyperbilirubinemia caused by hemolytic disease of newborn. Methods:Eighty cases of neonates with hyperbilirubinemia caused by hemolytic disease of newborn were randomly divided into two groups, intervention group received Blu-ray irradiation combined with comprehensive medication and control group received comprehensive medication. Before and after treatment, contents of serum TBIL, MDA, nerve function related molecules as well as liver and kidney function related molecules were detected.Results:After treatment, serum TBIL, MDA, MBP, S-100β, NSE, Cr, BUN, CysC,β2-MG, αα-GST and GLDH levels of both groups were lower than those before treatment; serum TBIL, MDA, MBP, S-100β, NSE, Cr, BUN, CysC,β2-MG,α-GST and GLDH levels of intervention group were lower than those of control group.Conclusion:Blu-ray irradiation combined with comprehensive treatment can more effectively reduce bilirubin level, protect nerve function and reduce oxidative stress damage to liver and kidney function; it has positive value in treatment of neonates with hyperbilirubinemia caused by hemolytic disease of newborn.

作者： 刊期： 2015年第11期

Objective:To study the effect of ropivacaine-fentanyl combined with spinal–epidural labor analgesia on maternal serum markers and TXB2/6-Keto-PGF1α proportion.Methods:40 cases of puerperas intending to receive vaginal delivery in our hospital were randomly divided into two groups. Combined group received fentanyl subarachnoid injection combined with ropivacaine epidural injection and control group received fentanyl combined with ropivacaine epidural injection. Then levels of serum pain mediators and inflammation related factors as well as TXB2/6-Keto-PGF1α proportion of both groups were detected. Results:In delivery process, contents of serum pain mediatorsβ-EP, NO, SP, PGE2, TNF-α, IL-6, CCL2 and CCR2 of combined group were significantly lower than those of control group, and IL-10 and TGb-βcontents were significantly higher than those of control group; In and after labor, serum TXB2 content and TXB2/6-keto-PGF1α proportion of combined group were lower than those of control group, while 6-keto-PGF1α content was higher than that of control group.Conclusion:Ropivacaine-fentanyl combined with spinal–epidural labor analgesia can achieve more precise analgesia effect, reduce contents of pain mediators, pro-inflammatory cytokines and chemokines, and regulate TXB2/6-Keto-PGF1ααbalance.

作者： 刊期： 2015年第11期

Objective:To explore the expression of VEGF, IL-6, and IL-8 in serum and peritoneal fluid of patients with endometriosis (EMT) and their clinical significances.Methods:EMT patients who were pathologically diagnosed after laparoscopy from February, 2014 to February, 2015 were included in the study and served as the observation group. Moreover, patients with benign ovarian tumor and healthy women who came for physical examination at the same period were selected and served as the disease control group and normal control group, respectively for correlation analysis. The levels of VEGF, IL-6, and IL-8 in serum and peritoneal fluid of subjects in the three groups were compared.Results:The levels of serum VEGF, IL-6, and IL-8 in the observation group were significantly higher than those in the disease control group and the normal control group (P<0.05), while the comparison between the disease control group and the normal control group was not statistically significant (P>0.05). The levels of VEGF, IL-6, and IL-8 in peritoneal fluid in the observation group were significantly higher than those in the disease control group (P<0.05). With the increasing of EMT staging, the levels of VEGF, IL-6, and IL-8 in serum and peritoneal fluid were correspondingly elevated. The levels of VEGF, IL-6, and IL-8 in serum and peritoneal fluid at stageⅢ-Ⅳ were significantly higher than those at stageⅠ-Ⅱ(P<0.05).Conclusions:VEGF, IL-6 and IL-8 are highly expressed in serum and peritoneal fluid of patients with EMT. With the progression of the disease, the expression of VEGF, IL-6 and IL-8 shows an increasing trend. Clinical detection of the changes of VEGF, IL-6, and IL-8 levels in serum and peritoneal fluid can monitor the progression of EMT condition.

作者： 刊期： 2015年第11期

Objective:To study the protective effect of diammonium glycyrrhizinate enteric-coated capsule on hepatic injury of leukemia tumor-bearing mice after chemotherapy.Methods: C57 mice were selected as research subjects, leukemia tumor-bearing mouse model was built, both chemotherapy group and treatment group received cyclophosphamide chemotherapy, and treatment group received diammonium glycyrrhizinate enteric-coated capsule treatment. Then liver enzyme contents in serum as well as percentage of apoptosis cells and oxidative stress product contents in liver tissue were detected.Results:Serum ALT, AST,α-GST and GLDH contents of chemotherapy group were higher than those of control group, and percentage of apoptosis cells as well as MDA, AOPP and 8-OhdG contents in liver tissue were higher than those of control group; serum ALT, AST,α-GST and GLDH contents of treatment group were lower than those of chemotherapy group, and percentage of apoptosis cells as well as MDA, AOPP and 8-OhdG contents in liver tissue were lower than those of chemotherapy group.Conclusion:diammonium glycyrrhizinate enteric-coated capsule has protective effect on hepatic injury of leukemia tumor-bearing mice after chemotherapy; mechanism of the protective effect may be reducing the oxidative stress and inhibiting hepatocyte apoptosis.

作者： 刊期： 2015年第11期

Objective:To explore the effect of acitretin in combined with NB-UVB on T lymphocyte subsets in the peripheral blood in patients with psoriasis vulgaris.Methods:A total of 90 patients with psoriasis vulgaris who were admitted in our department from May, 2013 to May, 2015 were included in the study and randomized into the observation group and the control group. The patients in the control group were given acitretin after dinner, 10 mg/time, twice each day, for 6 weeks. The patients in the observation group were given acitretin in combined with UVB, each irradiation for 30 min, three times every week, for 6 weeks. The changes of CD3+, CD4+, and CD8+ in the peripheral blood, PASI score, and the clinical efficacy before and after treatment in the two groups were observed.Results:The elevation degree of CD3+ and CD4+ after treatment in the observation group was significantly obvious that in the control group, while the declining degree of CD8+ was also significantly obvious that in the control group. The decreased degree of PASI score after treatment in the observation group was significantly superior to that in the control group. The total effective rate in the observation group (93.33%) was significantly superior to that in the control group (80.00%).Conclusions:Acitretin in combined with UVB in the treatment of psoriasis vulgaris can play its role by altering the imbalance state of T lymphocyte immune function. The combined treatment can enhance the therapeutic effect, therefore, it deserves to be widely recommended in the clinic.

作者： 刊期： 2015年第11期

Objective:To explore the effect and mechanism of ganglioside for hypoxia injury in newborn.Methods:A total of 200 cases of newborn patients in our hospital were analyzed. All the patients were divided into 4 groups, control and ganglioside groups with low, medium and high dose. The neonatal behavioral neurological assessment scores were counted in each group and the serum inflammatory factors and transforming growth factor-β (TGFβ)/Smad parameters were detected.Results:The neonatal behavioral neurological assessment scores were increased after ganglioside treatment and the serum interleukin (IL) 2/10, hypoxia inducible factorαand Smad1, Smad3 as well as TGFβ was decreased dramatically when compared with control group.Conclusions:Ganglioside exerts an effective effect on cerebral hypoxia in newborn mainly by inhibiting the TGFβ/Smad signaling pathway.

作者： 刊期： 2015年第11期

Objective:To explore the effects of early enteral nutrition combined with triple viable capsule of bacillus on inflammatory factors and intestinal mucosal barrier function in treatment of severe acute pancreatitis.Methods:118 cases of severe acute pancreatitis were randomly divided into two groups. The control group (59 cases) patients were treated with early enteral nutrition therapy, while the observation group (59 cases) was treated with early enteral nutrition combined with triple viable capsule of bacillus. The clinical efficacy of the two groups and the changes of the levels of inflammatory factors and the function of intestinal mucosal barrier were compared.Results:The time of abdominal pain disappearance, the abdominal distension disappeared, and the recovery time of the exhaust function of the observation group were (2.30±0.30) d, (3.39±0.51) d and (2.68±0.78) d, were significantly decreased compared with the control group (P<0.05). IL-6, IL-8, TNF-α and CRP of observation group were (33.19±355) g/L, (30.28±3.71) g/L, (36.33±3.53) g/L and (12.19±1.18) mg/L, were significantly lower compared with those before treatment (P<0.05) and was significantly lower than that of the control group (P<0.05). After treatment, D-lactate, DAO, endotoxin and exami of observation group were (544±0.54) mg/L, Dao (4.11±0.34) U/L, (0.65±0.18) EU/L, (0.15±0.07), were decreased significantly compared with those before treatment (P<0.05) and was significantly lower than that of the control group (P<0.05).Conclusion:Eearly enteral nutrition combined with triple viable capsule of bacillus on inflammatory factors and intestinal mucosal barrier function in treatment of SAP has significant effect, can rapidly improve the symptoms of patients, reduce inflammation, promote the recovery of intestinal mucosal barrier function, it is worth clinical reference and popularization and application.

作者： 刊期： 2015年第11期

Objective:To observe and analyze the change situation of immune indexes and oxidative stress state of children with recurrent respiratory tract infection.Methods:75 children with recurrent respiratory tract infection in our hospital from January 2014 to June 2015 were selected as observation group, 75 healthy children with health examination at the same time were selected as control group, then the immune indexes and oxidative stress state related serum indexes of two groups were detected,and the detection results of observation group with boys and girls, mild, moderate and severe disease were compared.Results: The cellular immune and erythrocyte immune and oxidative stress state related serum indexes of observation group were all worse than those of control group,and the detection results of observation group with mild, moderate and severe disease had obvious differences too, allP<0.05, while the differences of boys and girls had no significant differences, allP>0.05.Conclusion:The change of immune indexes and oxidative stress state of children with recurrent respiratory tract infection are obvious,and the differences of children with mild, moderate and severe disease are obvious too,while the differences of boys and girls are not obvious.

作者： 刊期： 2015年第11期

Objective:To explore the feasibility and effectiveness of 64 slice spiral CT in evaluating the patency of coronary artery after stent implantation.Methods:The 64 slice spiral CT image data of 125 patients after coronary artery stent implantation were collected, meanwhile, the image data of 25 patients underwent coronary angiography were also collected. The feasibility and accuracy of 64 slice spiral CT coronary artery stent imaging were comparatively analyzed. Results: The 64 slice spiral CT imaging quality with a stent diameter greater than 3.00 mm was significantly superior to that with a diameter of 2.25-3.00 mm. The CT imaging quality in the left main coronary artery and anterior descending artery was significantly higher than that in the left circumflex coronary artery. The CT imaging quality in the left main coronary artery was significantly higher than that in the right coronary artery. The CT reconstruction imaging quality in the drug coating stent was significantly superior to that in the bare metal stent. The sensitivity of 64 slice spiral CT was 100.00%, and the accuracy was 100.00%. In detecting the coronary artery with occlusion and stenosis (stent stenosis greater than 50%), the sensitivity was 90.00%, the false negative rate was 10.00%, and the positive predicative value was 100.00%.Conclusions:The effect of 64 slice spiral CT coronary imaging in evaluating the patency of coronary artery after stent implantation is highly consistent with that by coronary angiography, with a simple operation, less risk, and low cost, and thus, it can be completely taken as the imaging method in evaluating the patency of coronary artery after stent implantation.

作者： 刊期： 2015年第11期

Objective:To discuss the clinical value of Serum TSH combined with 3 kinds of VEGF (VEGF-C, VEGF-D and VEGFR-3) determination in the early diagnosis of papillary thyroid carcinoma (PTC). Method:Selected 37 cases of patients with thyroid benign tumor (Benign group) and 37 cases of patients with PTC (PTC group), then collected the serum of these both groups, to determine the TSH, VEGF-C, VEGF-D and VEGFR-3 levels of all cases by chemiluminescence immunoassay and enzyme linked immunosorbent assay respectively. Through Logistic model, to calculate the curve area of TSH combined with 3 kinds of VEGF.Results:PTC group: VEGF-C, VEGFR-3 and TSH levels were obviously higher than that in Benign group (P<0.05); and VEGF-C, VEGFR-3 and TSH levels inⅢ-Ⅳ period patients were obviously higher than that in I-Ⅱ period patients (P<0.05); AUC area of VEGF-C, VEGFR-3 and TSH were respectively 0.805, 0.736 and 0.710, reached to significance level (P<0.05); AUC area of combined diagnosis was 0.859.Conclusion:VEGF-C, VEGFR-3 and TSH between papillary thyroid carcinoma and thyroid benign tumor had significant difference. Combined determination could improve the early diagnose rate of PTC, and could be regarded as one of the important auxiliary index of PTC early diagnosis.

作者： 刊期： 2015年第11期

Objective:To explore the correlation of expressions of MDR1/P-gp and CerbB-2 in the colorectal cancer tissues and their clinical significance.Methods:A total of 86 colorectal cancer tissues specimens were included in the study. The immunohistochemical S-P method was used to detect the expressions of P-gp and CerbB-2, and their correlations were analyzed.Results:The positive rates of the expressions of MDR1/P-gp and CerbB-2 were 36% (31/86) and 28% (24/86), respectively. The positive expression rate of CerbB-2 in the colorectal cancer tissues at a clinical stage of III was significantly higher than that at stage I and II. The positive expression rates of MDR1/P-gp and CerbB-2 in the colorectal cancer tissues with axillary lymph node metastasis were significantly higher than those in the tissues without axillary lymph node metastasis. In the P-gp positive expression group, the positive rate of CerbB-2 was 75.5% (37/49), while the negative rate of CerbB-2 was 24.48% (12/49), and the difference was statistically significant (P<0.01). P-gp had a certain positive correlation with the positive expression rate of CerbB-2. Conclusions:P-gp and CerbB-2 play a certain role in the occurrence of multidrug resistance of colorectal cancer, and their expressions are correlated; therefore, the combination detection can provide an evidence for the chemotherapy choice of colorectal cancer.

作者： 刊期： 2015年第11期

Objective:To study the application value of SIB-CR combined with conventional chemotherapy for advanced central type of non-small cell lung cancer.Methods:60 patients with advanced central type of non-small cell lung cancer were randomly divided into two groups, SIB-CR group received simultaneous integrated boost conformal radiotherapy combined with chemotherapy, and conventional radiotherapy group received conventional radiotherapy combined with chemotherapy. Then cell apoptosis, protein contents of anti-apoptotic molecules and pro-apoptotic molecules in lung cancer tissue as well as lung cancer vitality indicators in serum were detected.Results:Compared with conventional radiotherapy group, apoptotic indexes in lung cancer tissue of SIB-CR group significantly increased; Fas and FasL contents were higher while Bcl-2 and Pim-1 contents were lower; serum Cyfra21-1, SCC and TSGF contents of SIB-CR group were lower than those of conventional radiotherapy group.Conclusion:SIB-CR combined with conventional chemotherapy can induce lung cancer cell apoptosis and regulate the expression of pro-apoptotic and anti-apoptotic genes; its killing effect on lung cancer cells is superior to that of conventional radiotherapy.

作者： 刊期： 2015年第11期

Objective:To explore molecular mechanism and biological function of miR-155 and its target genes on endometriosis.Methods: The expression of miR-155 in Ems patient and healthy control were assayed by RT-PCR. After miR-155 mimic and inhibitor were transfected into Ems endometrial cells for 48 h, the viability of cell was detected by MTT assay. Transwell migration and invasion assay were used to detect cell migration and invasion. The expression of cell apoptotic protein Bax and Bcl-2, matrix metalloproteinase (MMP 2) and MMP 9 were assayed by western blot.Results: The expression of miR-155 in Ems patient was more than that in the health control (P<0.01). After miR-155 mimic and inhibitor were transfected into Ems endometrial cells for 48 h, miR-155 over-expression could increase cell viability, and promoted cell migration and invasion, which was related to down-regulation of Bax along with up-regulation of Bcl-2, MMP 2 and MMP 9.Conclusion:These results suggested miR-155 lower expression inhibit endometrial cell proliferation and migration of the Ems.

作者： 刊期： 2015年第11期

Objective:To observe the effect of atorvastatin combined with ezetimibe on the levels of urine protein, PCT, serum lipid, and hs-CRP in patients with acute coronary syndrome (ACS). Methods:A total of 90 ACS patients who were admitted in our hospital were included in the study and randomized into A, B, and C groups with 30 cases in each group. The patients in A group were given atorvastatin (20 mg/d, a maintenance dose), the patients in B group were given atorvastatin (40 mg/d, a load dose), while the patients in C group were given atorvastatin in a load dose combined with ezetimibe (10 mg/d). The changes of 24 h UMA, PCT, serum lipid, and hs-CRP after two-week treatment in the three groups were observed, and the adverse reactions in the three groups were observed.Results:The improvements of urine protein, PCT, and serum hs-CRP concentration after treatment in B and C groups were significantly superior to those in A group (P<0.05). The improvements of urine protein, PCT, and serum hs-CRP concentration after treatment in C group were significantly superior to those in A and B groups (P<0.05). The levels of TC and LDL-C after treatment in B and C groups were significantly reduced when compared with those before treatment (P<0.05). The levels of TC and LDL-C after treatment in group A were not statistically different from those before treatment (P>0.05). No obviously adverse reactions occurred in the three groups.Conclusions:Atorvastatin in a load dose combined with ezetimibe can significantly adjust the levels of UMA, PCT, and serum lipid in ACS patients, reduce the concentrations of inflammatory factors, and play an active role in the treatment of ACS.

作者： 刊期： 2015年第11期

Objective:To explore the clinical effect and significance of adoptive immunotherapy of dendritic cell and cytokine-induced killer cell (DC-CIK) combined with the gamma knife in the treatment of middle and advanced hepatic carcinoma.Methods:42 patients with the middle and advanced primary hepatic carcinoma were randomly divided into two groups: 20 cases in the combination group were given the adoptive immunotherapy of DC-CIK cells and gamma knife radiotherapy; 22 cases in the control group were only given the gamma knife radiotherapy. The short-term effect, quality of life, overall survival and toxic and side effects were compared between two groups after the operation.Results: 3 months after the treatment, the short-term effect of combination group and control group was 70% and 54.5% respectively (P<0.05). Patients in the combination group performed better in the overall survival, change of T-cell subsets, PS score, decrease rate of AFP and degree of liver function than the control group, while the adiodermatitis at II and over and bone marrow suppression were also better than the control group. Conclusion:The adoptive immunotherapy of DC-CIK cells combined with the gamma knife in the treatment of middle and advanced hepatic carcinoma can prolong the overall survival, improve the quality of life, reduce the toxic and side effect and effectively promote the short-term clinical effect for patients.

作者： 刊期： 2015年第11期

Objective:To through counting serum high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB) and the ratio of the two to analyze its predictive value on acute myocardial infarction complicated with postoperative acute heart failure.Methods: 100 cases of acute myocardial infarction patients treated in our hospital from January 2013 to January 2015 were selected as research objects. Serum PAB and hs-CRP values on the next day of admission as well as after PCI surgery were recorded respectively. Then PAB data change before and after surgery, PAB and hs-CRP change with or without postoperative cardiovascular events (heart failure) as well as the value of the ratio of hs-CRP and PAB on prediction of acute myocardial infarction complicated with acute heart failure was compared.Results:Postoperative PAB in 100 cases of myocardial infarction patients increased from (0.19±0.05) to (0.24±0.06), and the differences had statistical significance; 40 cases had postoperative cardiovascular events (heart failure), incidence being 40%; PAB in patients without postoperative cardiovascular events (heart failure) increased significantly, hs-CRP decreased significantly, and the differences had statistical significance; Logistic regression univariate analysis showed that acute myocardial infarction complicated with heart failure was associated with diabetes, PAB, hs-CRP and In (hs-CRP/PAB), and multivariate analysis showed that it was associated with In (hs-CRP/PAB). Conclusion:hs-CRP in patients with acute myocardial infarction increases, PAB decreases, postoperative PAB increases relatively, hs-CRP and PAB data shows different degrees of change with or without postoperative cardiovascular (heart failure), and In (hs-CRP/PAB) is associated with acute myocardial infarction complicated with heart failure and can be used as its prediction index.

作者： 刊期： 2015年第11期

Objective:To explore the influence of inflammation factors and intestinal mucosal barrier function on severe acute pancreatitis patients treated with bifidobacterium triple viable capsules.Methods:88 cases severe acute pancreatitis patients were divided into observation group and control group according to admission order, 44 cases in each group, all patients were given conventional treatment, on this base, patients in observation group were treated by oral bifidobacterium triple viable capsules, they were treated for one week, detected the serum inflammatory factors: the tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and C-reactive protein (CRP) and intestinal mucosal barrier function index: endotoxin, diamine oxidase (DAO), D-lactic acid, urinary lactulose/mannitol (L/M) in the two groups before and after treatment.Results:The levels of TNF-α, IL-6 and CRP in two groups after treatment were significantly reduced than before treatment, and after treatment the levels of TNF-α, IL-6 and CRP in observation group was significantly lower than that of the control group, all the difference was statistically significant; The levels of endotoxin, DA, D-lactic acid, L/M in two groups after treatment were significantly reduced than before treatment, and the levels of endotoxin, DA, D-lactic acid,L/M after treatment in observation group was significantly lower than that of the control group, the difference was statistically significant.Conclusion: Based on conventional treatment combined bifidobacterium triple viable capsules can significantly reduce inflammation in patients with severe acute pancreatitis, it can protect the intestinal mucosal barrier function, and has important clinical significance.

作者： 刊期： 2015年第11期

Objective:To study the effect of ketamine combined with fluoxetine on behavior indexes and related gene expression in depression rat model.Methods:SD rats were used as experimental animals and randomly divided into control group (C group), model group (M group), ketamine group (K group), fluoxetine group (F group) and ketamine combined with fluoxetine group (KF group); chronic unpredictable stress depression models were built and different medications were given. Then behavior indicators were detected by tail suspension test and open field test; contents of monoamine neurotransmitters were determined by HPLC-electrochemical detection assay; mRNA contents of monoamine neurotransmitter-metabolizing enzymes, BDNF and its receptor were detected by PCR method.Results: (1)behavior indexes: compared with M group, behavior indexes of K group, F group and KF group were all improved; tail suspension immobility time and central grid staying time of KF group were shorter than those of K group and F group; squares crossed number, standing up number and decoration number were more than those of K group and F group; (2) molecular indexes: compared with M group, molecular markers of K group, F group and KF group were all improved; NE, 5-HT, TH, TPH, BDNF and TrkB contents in hippocampal and prefrontal cortex tissue of KF group were higher than those of K group and F group.Conclusion:Ketamine combined with fluoxetine therapy can more effectively reduce depression-related behavior; its mechanism may be related to the regulation of monoamine neurotransmitter metabolism and brain-derived neurotrophic factor expression in hippocampus and prefrontal cortex.

作者： 刊期： 2015年第11期

Objective:To study the role of miR-29b in Docetaxel caused dampened metastasis of gastric cancer cells.Methods: After treated by Docetaxel, the invasion and migration of SGC7901 cell were studied by Transwell and Wound Healing Assay. miR-29b levels was detected by qRT-PCR and its targets were detected by Western blot after SGC7901 cell was treated by Docetaxel. When transfected by miR-29b mimic, the invasion and migration of SGC7901 cell were studied by Transwell and Wound Healing Assay. Similarly, when treated by Docetaxel and anti-miR-29b simultaneously, the invasion and migration of SGC7901 cell were also studied by Transwell and Wound Healing Assay.Results:Docetaxel could inhibit the invasion and migration of SGC7901 cell; miR-29b was upregulated by Docetaxel in SGC7901 cell; miR-29b could inhibit the invasion and migration of SGC7901 cell; When miR-29b could not be upregulated by Docetaxel, the effects of Docetaxel on invasion and migration of SGC7901 cell would be dampened.Conclusion:Docetaxel upregulated miR-29b contributes to dampened metastasis of gastric cancer cells.

作者： 刊期： 2015年第11期

Objective:To explore the effect of rosuvastatin on serum inflammatory factors, oxidative stress and MPO, MMP-9 of patients with chronic heart failure (CHF).Methods:140 cases with CHF were selected as the study case, using the single blind method and were randomly divided into two groups, including 70 cases in the control group were treated with routine department of internal medicine treatment, while 70 patients in the observation group were treated with rosuvastatin on the basis of conventional department. The serum inflammatory factors, oxidative stress and MPO, MMP-9 of changes were detected and compared.Results:After treatment, the observation group in patients with LVEDD (36.62±2.56) mm was significantly reduced compared with before treatment, LVEF (57.22±2.80)% and E/A ratio (1.38±0.04) were significantly increased compared with before treatment, and the each index compared with the control group had significant difference. After treatment, the observation group in patients with IL-6 (5.44±0.74) ng/L, TNF alpha (3.44±0.43) ng/L and hs-CRP (18.82±2.10) mg/mL compared with those before treatment significantly reduced, and the each index compared with the control group had significant difference (P<0.05). After treatment, the observation group in patients with MDA (4.78±0.60) μmol/mL, MPO (481.14±22.22) mg/L and MMP-9 (62.30±6.33) ng/mL was significantly reduced compared with before treatment, SOD (125.35±6.43) U/mL compared with increased significantly, and the each index compared with the control group had significant difference.Conclusion:Conventional therapy combined with rosuvastatin on the effect of CHF is significant, and can significantly improve heart function, inhibit oxidative stress and anti-inflammation, and the clinical application value is higher.

作者： 刊期： 2015年第11期