Objective:To explore the expression change of serum and colon lavage fluid related indicators after probiotics combined with zinc preparations treatment of persistent diarrhea in children.Methods:80 cases of children with diarrhea treated in our hospital were selected. According to clinical symptoms, routine blood and stool test, they were all diagnosed with persistent diarrhea and randomly divided into control group and experimental group, 40 cases in each group. Control group received basic treatment and zinc preparations (zinc gluconate tablets) therapy; experimental group, based on treatment of control group, received probiotics (Siliankang) combined with zinc preparations treatment. Fasting serum and colon lavage fluid of both groups were collected before and after treatment to detect IL-6, IL-8, NO, MDA and SOD expression levels, and differences between two groups were compared.Results:After treatment, IL-6 and IL-8 expression levels in serum and colon lavage fluid of both groups decreased significantly than those before treatment, and those of experimental group decreased more significantly; after treatment, NO, MDA and SOD expression levels in serum and colon lavage fluid of both groups were significantly improved than those before treatment, and those of experimental group were closer to the normal levels than those of control group.Conclusions:Probiotics combined with zinc preparations treatment of persistent diarrhea in children has obvious curative effect; it effectively reduces expression levels of inflammatory cytokines and oxidative stress factors in serum and colon lavage fluid, and is worth popularization in future clinical treatment.

作者： 刊期： 2015年第11期

Objective:To explore the feasibility and effectiveness of 64 slice spiral CT in evaluating the patency of coronary artery after stent implantation.Methods:The 64 slice spiral CT image data of 125 patients after coronary artery stent implantation were collected, meanwhile, the image data of 25 patients underwent coronary angiography were also collected. The feasibility and accuracy of 64 slice spiral CT coronary artery stent imaging were comparatively analyzed. Results: The 64 slice spiral CT imaging quality with a stent diameter greater than 3.00 mm was significantly superior to that with a diameter of 2.25-3.00 mm. The CT imaging quality in the left main coronary artery and anterior descending artery was significantly higher than that in the left circumflex coronary artery. The CT imaging quality in the left main coronary artery was significantly higher than that in the right coronary artery. The CT reconstruction imaging quality in the drug coating stent was significantly superior to that in the bare metal stent. The sensitivity of 64 slice spiral CT was 100.00%, and the accuracy was 100.00%. In detecting the coronary artery with occlusion and stenosis (stent stenosis greater than 50%), the sensitivity was 90.00%, the false negative rate was 10.00%, and the positive predicative value was 100.00%.Conclusions:The effect of 64 slice spiral CT coronary imaging in evaluating the patency of coronary artery after stent implantation is highly consistent with that by coronary angiography, with a simple operation, less risk, and low cost, and thus, it can be completely taken as the imaging method in evaluating the patency of coronary artery after stent implantation.

作者： 刊期： 2015年第11期

Objective:To explore the effect of rosuvastatin on serum inflammatory factors, oxidative stress and MPO, MMP-9 of patients with chronic heart failure (CHF).Methods:140 cases with CHF were selected as the study case, using the single blind method and were randomly divided into two groups, including 70 cases in the control group were treated with routine department of internal medicine treatment, while 70 patients in the observation group were treated with rosuvastatin on the basis of conventional department. The serum inflammatory factors, oxidative stress and MPO, MMP-9 of changes were detected and compared.Results:After treatment, the observation group in patients with LVEDD (36.62±2.56) mm was significantly reduced compared with before treatment, LVEF (57.22±2.80)% and E/A ratio (1.38±0.04) were significantly increased compared with before treatment, and the each index compared with the control group had significant difference. After treatment, the observation group in patients with IL-6 (5.44±0.74) ng/L, TNF alpha (3.44±0.43) ng/L and hs-CRP (18.82±2.10) mg/mL compared with those before treatment significantly reduced, and the each index compared with the control group had significant difference (P<0.05). After treatment, the observation group in patients with MDA (4.78±0.60) μmol/mL, MPO (481.14±22.22) mg/L and MMP-9 (62.30±6.33) ng/mL was significantly reduced compared with before treatment, SOD (125.35±6.43) U/mL compared with increased significantly, and the each index compared with the control group had significant difference.Conclusion:Conventional therapy combined with rosuvastatin on the effect of CHF is significant, and can significantly improve heart function, inhibit oxidative stress and anti-inflammation, and the clinical application value is higher.

作者： 刊期： 2015年第11期

Objective:To explore the effect of caffeine citrate on the blood gas indexes in newborns with apnea.Methods: A total of 108 primary premature infants diagnosed with apnea were included in the study and randomized into the caffeine citrate treatment group and the aminophylline control group with 54 cases in each group. The apnea episode duration 72 h after medication, and the blood gas before medication and 24, 48, 72 h after medication between the two groups were compared.Results: The apnea episode duration 24, 48, 72 h after medication in the treatment group was significantly shorter than that in the control group. PaO2 24, 48, 72 h after medication in the treatment group was significantly higher than that in the control group, while PaCO2 was significantly reduced when compared with the control group.Conclusions:Caffeine citrate has achieved a significantly clinical effect in the treatment of newborn apnea, as a new therapeutic drug, is worthy of being widely recommended in the clinic.

作者： 刊期： 2015年第11期

Objective:To study the effect of ketamine combined with fluoxetine on behavior indexes and related gene expression in depression rat model.Methods:SD rats were used as experimental animals and randomly divided into control group (C group), model group (M group), ketamine group (K group), fluoxetine group (F group) and ketamine combined with fluoxetine group (KF group); chronic unpredictable stress depression models were built and different medications were given. Then behavior indicators were detected by tail suspension test and open field test; contents of monoamine neurotransmitters were determined by HPLC-electrochemical detection assay; mRNA contents of monoamine neurotransmitter-metabolizing enzymes, BDNF and its receptor were detected by PCR method.Results: (1)behavior indexes: compared with M group, behavior indexes of K group, F group and KF group were all improved; tail suspension immobility time and central grid staying time of KF group were shorter than those of K group and F group; squares crossed number, standing up number and decoration number were more than those of K group and F group; (2) molecular indexes: compared with M group, molecular markers of K group, F group and KF group were all improved; NE, 5-HT, TH, TPH, BDNF and TrkB contents in hippocampal and prefrontal cortex tissue of KF group were higher than those of K group and F group.Conclusion:Ketamine combined with fluoxetine therapy can more effectively reduce depression-related behavior; its mechanism may be related to the regulation of monoamine neurotransmitter metabolism and brain-derived neurotrophic factor expression in hippocampus and prefrontal cortex.

作者： 刊期： 2015年第11期

Objective:To study the expression of aminopeptidase N (CD13) in renal carcinoma and the effect of CD13 expression vector transfection on biological behavior of cancer cells.Methods:Renal carcinoma tissue and normal kidney tissue were collected and APN (CD13) contents in tissue were detected; renal carcinoma cell lines kevt-3 were cultured, 0 μg/mL, 10 μg/mL, 20 μg/mL, 40 μg/mL and 80 μg/mL of CD13 expression vector were transfected, and then migration ability, ATP generation capacity, and mRNA contents of migration and angiogenesis genes in cells were detected.Results:mRNA contents of APN in renal carcinoma tissue were higher than those in normal kidney tissue; the higher the clinical stage and pathological grade were, the higher the mRNA contents of APN in renal carcinoma tissue were; mRNA levels of APN in renal carcinoma tissue with lymph node metastasis were higher than those without lymph node metastasis;CD13 expression vector transfection could dose-dependently increase kevt-3 cell migration rate, ATP generation amount as well as mRNA contents of VEGF, HIF-1α, MMP9 and MMP10.Conclusion: Expression of aminopeptidase N (CD13) in renal carcinoma tissue abnormally increases; overexpression of CD13 can promote renal carcinoma cell migration and increase ATP generation as well as VEGF, HIF-1, MMP9 and MMP10 expression.

作者： 刊期： 2015年第11期

Objective:To investigate and study the influenced state of total laparoscopic hysterectomy for the blood viscosity and erythrocyte immune state of patients.Methods:A total of 58 patients who were treated with total hysterectomy in our hospital from June 2013 to February 2015 were the study subjects, the 29 cases in the control group were treated with routine open hysterectomy operation according to the operation types, the 29 cases in the observation group were treated with laparoscopic hysterectomy operation, then the preoperative and postoperative blood viscosity and erythrocyte immune state indexes of two groups were compared.Results:The blood viscosity indexes of the observation group at different postoperative time were all lower than the indexes of the control group, the erythrocyte immune state indexes were all better than those of the control group, and the detection results of two groups at the third day after the operation were all obviously worse than those at other times, their differences were statistically significant.Conclusions:The bad influence of total laparoscopic hysterectomy for the blood viscosity and erythrocyte immune state of patients are relatively smaller, and those postoperative indexes in recovery of patients are faster.

作者： 刊期： 2015年第11期

Objective:To study the effect of ropivacaine-fentanyl combined with spinal–epidural labor analgesia on maternal serum markers and TXB2/6-Keto-PGF1α proportion.Methods:40 cases of puerperas intending to receive vaginal delivery in our hospital were randomly divided into two groups. Combined group received fentanyl subarachnoid injection combined with ropivacaine epidural injection and control group received fentanyl combined with ropivacaine epidural injection. Then levels of serum pain mediators and inflammation related factors as well as TXB2/6-Keto-PGF1α proportion of both groups were detected. Results:In delivery process, contents of serum pain mediatorsβ-EP, NO, SP, PGE2, TNF-α, IL-6, CCL2 and CCR2 of combined group were significantly lower than those of control group, and IL-10 and TGb-βcontents were significantly higher than those of control group; In and after labor, serum TXB2 content and TXB2/6-keto-PGF1α proportion of combined group were lower than those of control group, while 6-keto-PGF1α content was higher than that of control group.Conclusion:Ropivacaine-fentanyl combined with spinal–epidural labor analgesia can achieve more precise analgesia effect, reduce contents of pain mediators, pro-inflammatory cytokines and chemokines, and regulate TXB2/6-Keto-PGF1ααbalance.

作者： 刊期： 2015年第11期

Objective:To explore the clinical effect and significance of adoptive immunotherapy of dendritic cell and cytokine-induced killer cell (DC-CIK) combined with the gamma knife in the treatment of middle and advanced hepatic carcinoma.Methods:42 patients with the middle and advanced primary hepatic carcinoma were randomly divided into two groups: 20 cases in the combination group were given the adoptive immunotherapy of DC-CIK cells and gamma knife radiotherapy; 22 cases in the control group were only given the gamma knife radiotherapy. The short-term effect, quality of life, overall survival and toxic and side effects were compared between two groups after the operation.Results: 3 months after the treatment, the short-term effect of combination group and control group was 70% and 54.5% respectively (P<0.05). Patients in the combination group performed better in the overall survival, change of T-cell subsets, PS score, decrease rate of AFP and degree of liver function than the control group, while the adiodermatitis at II and over and bone marrow suppression were also better than the control group. Conclusion:The adoptive immunotherapy of DC-CIK cells combined with the gamma knife in the treatment of middle and advanced hepatic carcinoma can prolong the overall survival, improve the quality of life, reduce the toxic and side effect and effectively promote the short-term clinical effect for patients.

作者： 刊期： 2015年第11期

Objective:To through counting serum high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB) and the ratio of the two to analyze its predictive value on acute myocardial infarction complicated with postoperative acute heart failure.Methods: 100 cases of acute myocardial infarction patients treated in our hospital from January 2013 to January 2015 were selected as research objects. Serum PAB and hs-CRP values on the next day of admission as well as after PCI surgery were recorded respectively. Then PAB data change before and after surgery, PAB and hs-CRP change with or without postoperative cardiovascular events (heart failure) as well as the value of the ratio of hs-CRP and PAB on prediction of acute myocardial infarction complicated with acute heart failure was compared.Results:Postoperative PAB in 100 cases of myocardial infarction patients increased from (0.19±0.05) to (0.24±0.06), and the differences had statistical significance; 40 cases had postoperative cardiovascular events (heart failure), incidence being 40%; PAB in patients without postoperative cardiovascular events (heart failure) increased significantly, hs-CRP decreased significantly, and the differences had statistical significance; Logistic regression univariate analysis showed that acute myocardial infarction complicated with heart failure was associated with diabetes, PAB, hs-CRP and In (hs-CRP/PAB), and multivariate analysis showed that it was associated with In (hs-CRP/PAB). Conclusion:hs-CRP in patients with acute myocardial infarction increases, PAB decreases, postoperative PAB increases relatively, hs-CRP and PAB data shows different degrees of change with or without postoperative cardiovascular (heart failure), and In (hs-CRP/PAB) is associated with acute myocardial infarction complicated with heart failure and can be used as its prediction index.

作者： 刊期： 2015年第11期

Objective:To explore the effect of acitretin in combined with NB-UVB on T lymphocyte subsets in the peripheral blood in patients with psoriasis vulgaris.Methods:A total of 90 patients with psoriasis vulgaris who were admitted in our department from May, 2013 to May, 2015 were included in the study and randomized into the observation group and the control group. The patients in the control group were given acitretin after dinner, 10 mg/time, twice each day, for 6 weeks. The patients in the observation group were given acitretin in combined with UVB, each irradiation for 30 min, three times every week, for 6 weeks. The changes of CD3+, CD4+, and CD8+ in the peripheral blood, PASI score, and the clinical efficacy before and after treatment in the two groups were observed.Results:The elevation degree of CD3+ and CD4+ after treatment in the observation group was significantly obvious that in the control group, while the declining degree of CD8+ was also significantly obvious that in the control group. The decreased degree of PASI score after treatment in the observation group was significantly superior to that in the control group. The total effective rate in the observation group (93.33%) was significantly superior to that in the control group (80.00%).Conclusions:Acitretin in combined with UVB in the treatment of psoriasis vulgaris can play its role by altering the imbalance state of T lymphocyte immune function. The combined treatment can enhance the therapeutic effect, therefore, it deserves to be widely recommended in the clinic.

作者： 刊期： 2015年第11期

Objective:To study the correlation of HIFs/PPAR signaling pathway activation degree and lipid metabolism in liver tissue of alcoholic fatty liver rat model.Methods:Adult SD rats were selected and alcoholic fatty liver rat models were established by alcohol administration and high-fat diet feeding. Liver tissue was collected and contents of HIF-1α, PPARγ and lipid metabolism-related enzymes were detected; serum was collected and contents of lipid metabolism indexes and liver cell damage indexes were detected.Results:(1) one week, two weeks, three weeks and four weeks after models were established, HIF-1αα in livers of the model group showed an increasing trend and PPARγ showed a decreasing trend; HIF-1α content was higher than that of the control group and PPARγ content was lower than that of the control group; (2) contents of apoCII, apoCIII,α-GST and GLDH in serum as well as levels of FAT, FABP1, FAS, ACC and ACAT-2 in liver tissue of the model group all significantly increased, and were positively correlated with HIF-1α and negatively correlated with PPARγ.Conclusion:Transcription factor HIF-1α content abnormally increases and PPARγ content abnormally decreases in liver tissue of alcoholic fatty liver rat models; it results in abnormal lipid metabolism and liver cell damage through increasing the expression of lipid metabolism-related enzymes in the liver.

作者： 刊期： 2015年第11期

Objective:To explore the impact of serum free amino acid and cytokines in patients with tuberculosis treated by Moxifloxacin.Methods:Chose 130 cases pulmonary tuberculosis patients,they were divided into observation group and control group according to random number table method, 65 cases in each group, all patients were given tuberculosis standard treatment, and on this basis, patients in control group were given levofloxacin tablets, patients in observation group were given moxifloxacin hydrochloride oral, they were treated for 6 months, compared the serum free amino acid and cytokine interleukin-18 (IL-18), tumor necrosis factor alpha-gamma (TNF-α), interferon (IFN-γ), interleukin-10 (IL-10) between two groups before and after treatment. The serum isoleucine, phenylalanine, threonine, leucine, valine, aspartic acid, glutamic acid and arginine in two groups after were increased significantly than before treatment, the difference was statistically significant, acquired aspartic acid, glutamic acid in observation group after treatment were significantly higher than the control group after treatment, the difference was statistically significant; The serum IL-18, IFN-γ, TNF-α and IL-10 in two groups after treatment were significantly reduced, the difference was statistically significant (P<0.05); the serum IL-18, IFN-γ, TNF-α and IL-10 in observation group after treatment were significantly lower than the control group after treatment, the difference was statistically significant.Conclusion:Compared with levofloxacin, moxifloxacin treatment tuberculosis can improve the patients' serum free amino acid levels, adjust the Th1/Th2 balance.

作者： 刊期： 2015年第11期

Objective:To study the vitamin D3 levels in primary Sjogren's syndrome patients and its correlation with severity and immune function.Methods:Active pSS patients, stable pSS patients and healthy volunteers were chosen for study. Peripheral blood was collected, mononuclear cells were isolated and percentages of CD27high plasma cells and CD27+ memory B cells were detected; serum was collected and contents of 1,25(OH)2D3, TNF-α, IL-6, IL-10 and IL-17 were detected.Results:(1) 1,25(OH)2D3 contents in serum as well as CD27high plasma cell and CD27+ memory B cell contents in peripheral blood of pSS group were lower than those of control group; serum TNF-α, IL-6 and IL-17 contents were higher than those of control group and IL-10 contents were lower than those of control group; (2) 1,25(OH)2D3 contents in serum as well as CD27high plasma cell and CD27+ memory B cell contents in peripheral blood of active pSS patients were lower than those of stable pSS patients; serum TNF-α, IL-6 and IL-17 contents were higher than those of stable pSS patients and IL-10 contents were lower than those of stable pSS patients; (3) 1,25(OH)2D3 level was positively correlated with contents of CD27highplasma cells, CD27+ memory B cells and IL-10, and negatively correlated with TNF-α, IL-6 and IL-17 contents.Conclusion:Abnormal reduction of Vitamin D3 levels is involved in the pathogenesis of primary Sjogren's syndrome and closely related to the severity and immune function of the disease.

作者： 刊期： 2015年第11期

Objective:To study the application value of SIB-CR combined with conventional chemotherapy for advanced central type of non-small cell lung cancer.Methods:60 patients with advanced central type of non-small cell lung cancer were randomly divided into two groups, SIB-CR group received simultaneous integrated boost conformal radiotherapy combined with chemotherapy, and conventional radiotherapy group received conventional radiotherapy combined with chemotherapy. Then cell apoptosis, protein contents of anti-apoptotic molecules and pro-apoptotic molecules in lung cancer tissue as well as lung cancer vitality indicators in serum were detected.Results:Compared with conventional radiotherapy group, apoptotic indexes in lung cancer tissue of SIB-CR group significantly increased; Fas and FasL contents were higher while Bcl-2 and Pim-1 contents were lower; serum Cyfra21-1, SCC and TSGF contents of SIB-CR group were lower than those of conventional radiotherapy group.Conclusion:SIB-CR combined with conventional chemotherapy can induce lung cancer cell apoptosis and regulate the expression of pro-apoptotic and anti-apoptotic genes; its killing effect on lung cancer cells is superior to that of conventional radiotherapy.

作者： 刊期： 2015年第11期

Objective:To study the killing effect of different doses of preoperative iodine 131 therapy on thyroid cancer cells and its effect on salivary gland function.Methods:Patients diagnosed with thyroid cancer in our hospital from May 2013 to June 2014 were enrolled for study, given preoperative iodine 131 therapy and randomly divided into control group, low dose group, middle dose group and high dose group. Then cell apoptotic rate, cell cycle, cancer promoting gene and cancer suppressor gene expression in thyroid carcinoma tissue as well as salivary gland function were detected.Results: (1) cancer cell killing effect: compared with control group, cell apoptotic rates and number of cells in G0/G1 phase of low dose group, middle dose group and high dose group increased, number of cells in S and G2/M phase decreased, BRAF, Livin, MCM7 and CDK2 expression decreased, CCNG2 and PTEN expression increased; cell killing effect of middle dose group and high dose group were better than that of low dose group, and cell killing effect of middle dose group and high dose group had no differences; (2) salivary gland function: compared with control group, UI and SR in bilateral parotid and bilateral submandibular glands of low dose group, middle dose group and high dose group decreased; salivary gland damage effect of low dose group and middle dose group were weaker than that of high dose group, and salivary gland damage effect of low dose group and middle dose group had no differences.Conclusion:Middle dose of iodine 131 can take the killing effect on cancer cells and the protective effect on salivary glands into account; it’s an ideal dosage for preoperative iodine 131 internal radiation therapy of thyroid cancer patients.

作者： 刊期： 2015年第11期

Objective:To explore the value of arterial blood gas analysis and electrolyte determination in the diagnosis of neonatal asphyxia.Methods: A total of 100 neonates with asphyxia who were admitted in our department from March, 2013 to March, 2014 were included in the study and divided into the mild asphyxia group and the severe asphyxia group according to Apgar scoring. Moreover, 50 normal neonates were served as the control group and used for comparative analysis. AVL blood-gas analyzer was used to detect the levels of pH, PaO2, HCO3-, BE, PaCO2, K+, Na+, Cl-, and Ca2+.Results:The concentrations of pH, PaO2, HCO3-, and BE in the severe asphyxia group were significantly lower than those in the mild asphyxia group and the control group, while PaCO2 level was significantly higher than that in the mild asphyxia group and the control group. The comparison of the various indicators between the control group and the mild asphyxia group was not statistically significant. The comparison of serum K+, Na+,and Cl- levels among the control group, the mild asphyxia group, and the severe asphyxia group was not statistically significant. The serum Ca2+ level in the severe asphyxia group was significantly lower than that in the mild asphyxia group and the control group, while the comparison between the mild asphyxia group and the control group was also statistically significant.Conclusions:Blood gas analysis and electrolyte determination to the arterial blood in neonates can compensate for the insufficiency of Apgar scoring and provide an objective evidence for the diagnosis of neonatal asphyxia and the estimation of severity degree. Clinical combination with Apgar scoring is of great significance in enhancing the diagnosis of neonatal asphyxia and the accuracy of severity evaluation.

作者： 刊期： 2015年第11期

Objective:To study the hemodynamic condition of uterine artery and renal artery in preeclampsia patients and its relationship with endothelial function and invasive function. Methods:Preeclampsia puerperas were enrolled in observation group of the research, including 20 cases each with mild preeclampsia, moderate preeclampsia and severe preeclampsia; healthy puerperas were enrolled in control group. Then color Doppler ultrasound was used to detect hemodynamic parameters of uterine spiral artery and bilateral renal interlobar artery, enzyme-linked immunosorbent assay was used to detect endothelial function indexes in serum, and PCR was used to detect invasive function parameters in placenta.Results: S/D, PI and RI of uterine spiral artery and bilateral renal interlobar artery in mild, moderate and severe preeclampsia patients were all higher than those of control group; the more severe the preeclampsia condition was, the higher the S/D, PI and RI of uterine spiral artery and bilateral renal interlobar artery were; mRNA contents of Cst L, Cst D and MMP-9 in placenta of mild, moderate and severe preeclampsia patients were lower than those of control group, and mRNA contents of RECK as well as serum sFlt-1, sEng, AT1-AA and AngII contents were higher than those of control group; the more severe the disease degree was, the lower the mRNA contents of Cst L, Cst D, and MMP-9 were, the higher the mRNA contents of RECK as well as serum sFlt-1, sEng, AT1-AA and AngII contents were.Conclusion:Resistance of uterine artery and renal artery in preeclampsia patients increases, and it is closely related to endothelial dysfunction and invasive function loss.

作者： 刊期： 2015年第11期

Objective:To explore the diagnostic value of the combined detection ofβ2-MG, AFP, SF, and CEA in the primary hepatic cancer (PHC).Methods:A total of 70 HPC patients, 30 hepatic cirrhosis patients, and 30 healthy individuals were included in the study. A volume of 3 mL morning fasting blood from the patients in the three groups was taken. The radioimmunoassay was used to detect the contents of serumβ2-MG, AFP, SF, and CEA.Results: The contents of serumβ2-MG, AFP, SF, and CEA in the PHC group were significantly higher than those in the hepatic cirrhosis group and the control group (P<0.05). The contents of serumβ2-MG, AFP, and CEA in the hepatic cirrhosis group were significantly higher than those in the control group (P<0.05). The comparison of serum SF content between the hepatic cirrhosis group and the control group was not statistically significant. The detection positive rates of serumβ2-MG, AFP, SF, and CEA in the PHC patients were 81.42%, 65.71%, 51.43%, and 12.86%, respectively. The positive rate by the combined detection of four tumor markers could reach 97.14%, and was significantly higher than that by a unique detection. The comparison of serumβ2-MG and AFP in the PHC patients was not comparable.Conclusions:The contents of serumβ2-MG, AFP, SF, and CEA in the PHC patients are significantly higher than those in the hepatic cirrhosis patients and the healthy individuals. The combined detection of serumβ2-MG, AFP, SF, and CEA can contribute for the screening of PHC, and reduce the missed diagnosis rate of PHC. Serumβ2-MG is an independent tumor marker with no relation to AFP, SF, and CEA.

作者： 刊期： 2015年第11期

Objective:To observe and study the influence degree of hysteroscope examination for the comprehensive stress state of patients with recurrent spontaneous abortion.Methods:Seventy patients with recurrent spontaneous abortion who were intervened with hysteroscope examination in our hospital from January 2013 to April 2015 were selected as the study object, and they were divided into Group A (normal uterine cavity group, 35 cases) and Group B (intrauterine lesions group, 35 cases) according to the final examination results. Then the blood expression levels of stress hormones and pain stress indexes of two groups before the examination, at 5 min during the examination and at 5 min after the examination were detected, and the detection results of two groups at different times were compared.Results:The blood expression levels of stress hormones and pain stress indexes of Group B before the examination, at 5 min during the examination and at 5 min after the examination were all higher than those of Group A. And the blood expression levels of two groups at 5 min during the examination were all higher than those before the examination and at 5 min after the examination. The differences were all significant.Conclusions:The influence of hysteroscope examination for the comprehensive stress state of patients with recurrent spontaneous abortion is obvious, and it should be paid more attention to the control of stress degree of patients with intrauterine lesions during operation.

作者： 刊期： 2015年第11期