Objective:To explore the effect of acitretin in combined with NB-UVB on T lymphocyte subsets in the peripheral blood in patients with psoriasis vulgaris.Methods:A total of 90 patients with psoriasis vulgaris who were admitted in our department from May, 2013 to May, 2015 were included in the study and randomized into the observation group and the control group. The patients in the control group were given acitretin after dinner, 10 mg/time, twice each day, for 6 weeks. The patients in the observation group were given acitretin in combined with UVB, each irradiation for 30 min, three times every week, for 6 weeks. The changes of CD3+, CD4+, and CD8+ in the peripheral blood, PASI score, and the clinical efficacy before and after treatment in the two groups were observed.Results:The elevation degree of CD3+ and CD4+ after treatment in the observation group was significantly obvious that in the control group, while the declining degree of CD8+ was also significantly obvious that in the control group. The decreased degree of PASI score after treatment in the observation group was significantly superior to that in the control group. The total effective rate in the observation group (93.33%) was significantly superior to that in the control group (80.00%).Conclusions:Acitretin in combined with UVB in the treatment of psoriasis vulgaris can play its role by altering the imbalance state of T lymphocyte immune function. The combined treatment can enhance the therapeutic effect, therefore, it deserves to be widely recommended in the clinic.

作者： 刊期： 2015年第11期

Objective:To explore the expression change of serum and colon lavage fluid related indicators after probiotics combined with zinc preparations treatment of persistent diarrhea in children.Methods:80 cases of children with diarrhea treated in our hospital were selected. According to clinical symptoms, routine blood and stool test, they were all diagnosed with persistent diarrhea and randomly divided into control group and experimental group, 40 cases in each group. Control group received basic treatment and zinc preparations (zinc gluconate tablets) therapy; experimental group, based on treatment of control group, received probiotics (Siliankang) combined with zinc preparations treatment. Fasting serum and colon lavage fluid of both groups were collected before and after treatment to detect IL-6, IL-8, NO, MDA and SOD expression levels, and differences between two groups were compared.Results:After treatment, IL-6 and IL-8 expression levels in serum and colon lavage fluid of both groups decreased significantly than those before treatment, and those of experimental group decreased more significantly; after treatment, NO, MDA and SOD expression levels in serum and colon lavage fluid of both groups were significantly improved than those before treatment, and those of experimental group were closer to the normal levels than those of control group.Conclusions:Probiotics combined with zinc preparations treatment of persistent diarrhea in children has obvious curative effect; it effectively reduces expression levels of inflammatory cytokines and oxidative stress factors in serum and colon lavage fluid, and is worth popularization in future clinical treatment.

作者： 刊期： 2015年第11期

Objective:To study the protective effect of diammonium glycyrrhizinate enteric-coated capsule on hepatic injury of leukemia tumor-bearing mice after chemotherapy.Methods: C57 mice were selected as research subjects, leukemia tumor-bearing mouse model was built, both chemotherapy group and treatment group received cyclophosphamide chemotherapy, and treatment group received diammonium glycyrrhizinate enteric-coated capsule treatment. Then liver enzyme contents in serum as well as percentage of apoptosis cells and oxidative stress product contents in liver tissue were detected.Results:Serum ALT, AST,α-GST and GLDH contents of chemotherapy group were higher than those of control group, and percentage of apoptosis cells as well as MDA, AOPP and 8-OhdG contents in liver tissue were higher than those of control group; serum ALT, AST,α-GST and GLDH contents of treatment group were lower than those of chemotherapy group, and percentage of apoptosis cells as well as MDA, AOPP and 8-OhdG contents in liver tissue were lower than those of chemotherapy group.Conclusion:diammonium glycyrrhizinate enteric-coated capsule has protective effect on hepatic injury of leukemia tumor-bearing mice after chemotherapy; mechanism of the protective effect may be reducing the oxidative stress and inhibiting hepatocyte apoptosis.

作者： 刊期： 2015年第11期

Objective:To study the role of miR-29b in Docetaxel caused dampened metastasis of gastric cancer cells.Methods: After treated by Docetaxel, the invasion and migration of SGC7901 cell were studied by Transwell and Wound Healing Assay. miR-29b levels was detected by qRT-PCR and its targets were detected by Western blot after SGC7901 cell was treated by Docetaxel. When transfected by miR-29b mimic, the invasion and migration of SGC7901 cell were studied by Transwell and Wound Healing Assay. Similarly, when treated by Docetaxel and anti-miR-29b simultaneously, the invasion and migration of SGC7901 cell were also studied by Transwell and Wound Healing Assay.Results:Docetaxel could inhibit the invasion and migration of SGC7901 cell; miR-29b was upregulated by Docetaxel in SGC7901 cell; miR-29b could inhibit the invasion and migration of SGC7901 cell; When miR-29b could not be upregulated by Docetaxel, the effects of Docetaxel on invasion and migration of SGC7901 cell would be dampened.Conclusion:Docetaxel upregulated miR-29b contributes to dampened metastasis of gastric cancer cells.

作者： 刊期： 2015年第11期

Objective:To study the modulation effect of Blu-ray irradiation combined with comprehensive treatment on serum indicators of neonates with hyperbilirubinemia caused by hemolytic disease of newborn. Methods:Eighty cases of neonates with hyperbilirubinemia caused by hemolytic disease of newborn were randomly divided into two groups, intervention group received Blu-ray irradiation combined with comprehensive medication and control group received comprehensive medication. Before and after treatment, contents of serum TBIL, MDA, nerve function related molecules as well as liver and kidney function related molecules were detected.Results:After treatment, serum TBIL, MDA, MBP, S-100β, NSE, Cr, BUN, CysC,β2-MG, αα-GST and GLDH levels of both groups were lower than those before treatment; serum TBIL, MDA, MBP, S-100β, NSE, Cr, BUN, CysC,β2-MG,α-GST and GLDH levels of intervention group were lower than those of control group.Conclusion:Blu-ray irradiation combined with comprehensive treatment can more effectively reduce bilirubin level, protect nerve function and reduce oxidative stress damage to liver and kidney function; it has positive value in treatment of neonates with hyperbilirubinemia caused by hemolytic disease of newborn.

作者： 刊期： 2015年第11期

Objective:To investigate protective effects ofMallotus furetianus(M. furetianus)on functions of endothelial progenitor cells (EPCs) in atherosclerotic rats.Methods:Atherosclerosis was established by intraperitoneal injection of vitamin D3 combined with high fat diet for 9 weeks. Extracts ofM. furetianus were given to prevent damage of EPCs in dose of 0.081 g/kg and 0.026 g/kg. Rats were sacrificed, and then mononuclear cells were isolated from bone marrow to culture EPCs and test the functions of EPCs.Results:M. furetianus can improve the capacities of EPCs on proliferation, migration, adhesion, and tubule formation in doses of 0.081 g/kg; improve adhesion, and tubule formation in dose of 0.026 g/kg in atherosclerotic rats. Conclusion:M. furetianus can protect functions of EPCs in atherosclerotic rats.

作者： 刊期： 2015年第11期

Objective:To explore the impact of serum free amino acid and cytokines in patients with tuberculosis treated by Moxifloxacin.Methods:Chose 130 cases pulmonary tuberculosis patients,they were divided into observation group and control group according to random number table method, 65 cases in each group, all patients were given tuberculosis standard treatment, and on this basis, patients in control group were given levofloxacin tablets, patients in observation group were given moxifloxacin hydrochloride oral, they were treated for 6 months, compared the serum free amino acid and cytokine interleukin-18 (IL-18), tumor necrosis factor alpha-gamma (TNF-α), interferon (IFN-γ), interleukin-10 (IL-10) between two groups before and after treatment. The serum isoleucine, phenylalanine, threonine, leucine, valine, aspartic acid, glutamic acid and arginine in two groups after were increased significantly than before treatment, the difference was statistically significant, acquired aspartic acid, glutamic acid in observation group after treatment were significantly higher than the control group after treatment, the difference was statistically significant; The serum IL-18, IFN-γ, TNF-α and IL-10 in two groups after treatment were significantly reduced, the difference was statistically significant (P<0.05); the serum IL-18, IFN-γ, TNF-α and IL-10 in observation group after treatment were significantly lower than the control group after treatment, the difference was statistically significant.Conclusion:Compared with levofloxacin, moxifloxacin treatment tuberculosis can improve the patients' serum free amino acid levels, adjust the Th1/Th2 balance.

作者： 刊期： 2015年第11期

Objective:To study the miRNA-21 content in cervical cancer tissue and analyze its downstream target molecules.Methods:Patients with different FIGO stages of cervical cancer and healthy subjects were selected, cervical cancer tissue and normal cervical tissue were collected, and contents of miRNA-21 and apoptotic genes were detected; cervical cancer SiHa cells were cultured, miRNA-21 mimics and inhibitors were transfected, and then apoptotic gene contents were detected.Results:miRNA-21 contents in different stages of cervical cancer tissue were all higher than those in normal cervical tissue, mRNA contents of p16ink4a, ASPP1, Fas and GRIM-19 were lower than those in normal tissue, and mRNA contents of p16ink4a, ASPP1, Fas and GRIM-19 were negatively correlated with miRNA-21 contents; after miRNA-21 mimics were transfected, mRNA contents of p16ink4a, ASPP1, Fas and GRIM-19 significantly decreased, and after miRNA-21 inhibitors were transfected, mRNA contents of p16ink4a, ASPP1, Fas and GRIM-19 significantly increased.Conclusion:miRNA-21 contents in cervical cancer tissue significantly increase; downstream target genes of this miRNA may be apoptotic genes p16ink4a, ASPP1, Fas and GRIM-19.

作者： 刊期： 2015年第11期

Objective:To through counting serum high-sensitivity C-reactive protein (hs-CRP), prealbumin (PAB) and the ratio of the two to analyze its predictive value on acute myocardial infarction complicated with postoperative acute heart failure.Methods: 100 cases of acute myocardial infarction patients treated in our hospital from January 2013 to January 2015 were selected as research objects. Serum PAB and hs-CRP values on the next day of admission as well as after PCI surgery were recorded respectively. Then PAB data change before and after surgery, PAB and hs-CRP change with or without postoperative cardiovascular events (heart failure) as well as the value of the ratio of hs-CRP and PAB on prediction of acute myocardial infarction complicated with acute heart failure was compared.Results:Postoperative PAB in 100 cases of myocardial infarction patients increased from (0.19±0.05) to (0.24±0.06), and the differences had statistical significance; 40 cases had postoperative cardiovascular events (heart failure), incidence being 40%; PAB in patients without postoperative cardiovascular events (heart failure) increased significantly, hs-CRP decreased significantly, and the differences had statistical significance; Logistic regression univariate analysis showed that acute myocardial infarction complicated with heart failure was associated with diabetes, PAB, hs-CRP and In (hs-CRP/PAB), and multivariate analysis showed that it was associated with In (hs-CRP/PAB). Conclusion:hs-CRP in patients with acute myocardial infarction increases, PAB decreases, postoperative PAB increases relatively, hs-CRP and PAB data shows different degrees of change with or without postoperative cardiovascular (heart failure), and In (hs-CRP/PAB) is associated with acute myocardial infarction complicated with heart failure and can be used as its prediction index.

作者： 刊期： 2015年第11期

Objective:To study the hemodynamic condition of uterine artery and renal artery in preeclampsia patients and its relationship with endothelial function and invasive function. Methods:Preeclampsia puerperas were enrolled in observation group of the research, including 20 cases each with mild preeclampsia, moderate preeclampsia and severe preeclampsia; healthy puerperas were enrolled in control group. Then color Doppler ultrasound was used to detect hemodynamic parameters of uterine spiral artery and bilateral renal interlobar artery, enzyme-linked immunosorbent assay was used to detect endothelial function indexes in serum, and PCR was used to detect invasive function parameters in placenta.Results: S/D, PI and RI of uterine spiral artery and bilateral renal interlobar artery in mild, moderate and severe preeclampsia patients were all higher than those of control group; the more severe the preeclampsia condition was, the higher the S/D, PI and RI of uterine spiral artery and bilateral renal interlobar artery were; mRNA contents of Cst L, Cst D and MMP-9 in placenta of mild, moderate and severe preeclampsia patients were lower than those of control group, and mRNA contents of RECK as well as serum sFlt-1, sEng, AT1-AA and AngII contents were higher than those of control group; the more severe the disease degree was, the lower the mRNA contents of Cst L, Cst D, and MMP-9 were, the higher the mRNA contents of RECK as well as serum sFlt-1, sEng, AT1-AA and AngII contents were.Conclusion:Resistance of uterine artery and renal artery in preeclampsia patients increases, and it is closely related to endothelial dysfunction and invasive function loss.

作者： 刊期： 2015年第11期

Objective:To explore the correlation of expressions of MDR1/P-gp and CerbB-2 in the colorectal cancer tissues and their clinical significance.Methods:A total of 86 colorectal cancer tissues specimens were included in the study. The immunohistochemical S-P method was used to detect the expressions of P-gp and CerbB-2, and their correlations were analyzed.Results:The positive rates of the expressions of MDR1/P-gp and CerbB-2 were 36% (31/86) and 28% (24/86), respectively. The positive expression rate of CerbB-2 in the colorectal cancer tissues at a clinical stage of III was significantly higher than that at stage I and II. The positive expression rates of MDR1/P-gp and CerbB-2 in the colorectal cancer tissues with axillary lymph node metastasis were significantly higher than those in the tissues without axillary lymph node metastasis. In the P-gp positive expression group, the positive rate of CerbB-2 was 75.5% (37/49), while the negative rate of CerbB-2 was 24.48% (12/49), and the difference was statistically significant (P<0.01). P-gp had a certain positive correlation with the positive expression rate of CerbB-2. Conclusions:P-gp and CerbB-2 play a certain role in the occurrence of multidrug resistance of colorectal cancer, and their expressions are correlated; therefore, the combination detection can provide an evidence for the chemotherapy choice of colorectal cancer.

作者： 刊期： 2015年第11期

Objective:To explore the value of arterial blood gas analysis and electrolyte determination in the diagnosis of neonatal asphyxia.Methods: A total of 100 neonates with asphyxia who were admitted in our department from March, 2013 to March, 2014 were included in the study and divided into the mild asphyxia group and the severe asphyxia group according to Apgar scoring. Moreover, 50 normal neonates were served as the control group and used for comparative analysis. AVL blood-gas analyzer was used to detect the levels of pH, PaO2, HCO3-, BE, PaCO2, K+, Na+, Cl-, and Ca2+.Results:The concentrations of pH, PaO2, HCO3-, and BE in the severe asphyxia group were significantly lower than those in the mild asphyxia group and the control group, while PaCO2 level was significantly higher than that in the mild asphyxia group and the control group. The comparison of the various indicators between the control group and the mild asphyxia group was not statistically significant. The comparison of serum K+, Na+,and Cl- levels among the control group, the mild asphyxia group, and the severe asphyxia group was not statistically significant. The serum Ca2+ level in the severe asphyxia group was significantly lower than that in the mild asphyxia group and the control group, while the comparison between the mild asphyxia group and the control group was also statistically significant.Conclusions:Blood gas analysis and electrolyte determination to the arterial blood in neonates can compensate for the insufficiency of Apgar scoring and provide an objective evidence for the diagnosis of neonatal asphyxia and the estimation of severity degree. Clinical combination with Apgar scoring is of great significance in enhancing the diagnosis of neonatal asphyxia and the accuracy of severity evaluation.

作者： 刊期： 2015年第11期

Objective:To study the effect of preoperative compound rhizomacurcumaepowder treatment on serum markers and related signaling pathways function in endometrial tissue of patients with endometriosis.Methods:Endometriosis patients in our hospital were chosen for study and randomly divided into the treatment group (n=35) and the control group (n=35). The treatment group received preoperative compound rhizomacurcumaepowder treatment; the control group received preoperative conventional treatment. Then serum markers and function of related signaling pathways in endometrial tissues were compared.Results:After drug treatment, serum SCF, SDC-1, HLA-G, VEGF and Ang-2 contents of treatment group showed a significantly decreasing trend; mRNA contents and protein contents of Wnt, Frizzled, Dsh,β-catenin, cyclinD1, integrinα6β1, ERK1, ERK2, MMP9 and MMP27 in ectopic endometrial tissue of the treatment group all showed a significantly decreasing trend.Conclusion:Preoperative compound rhizomacurcumaepowder treatment is helpful to control the condition of endometriosis and inhibit the activation of cell cycle related signaling pathways and invasion related signaling pathways in ectopic endometrial tissue.

作者： 刊期： 2015年第11期

Objective:To study the killing effect of different doses of preoperative iodine 131 therapy on thyroid cancer cells and its effect on salivary gland function.Methods:Patients diagnosed with thyroid cancer in our hospital from May 2013 to June 2014 were enrolled for study, given preoperative iodine 131 therapy and randomly divided into control group, low dose group, middle dose group and high dose group. Then cell apoptotic rate, cell cycle, cancer promoting gene and cancer suppressor gene expression in thyroid carcinoma tissue as well as salivary gland function were detected.Results: (1) cancer cell killing effect: compared with control group, cell apoptotic rates and number of cells in G0/G1 phase of low dose group, middle dose group and high dose group increased, number of cells in S and G2/M phase decreased, BRAF, Livin, MCM7 and CDK2 expression decreased, CCNG2 and PTEN expression increased; cell killing effect of middle dose group and high dose group were better than that of low dose group, and cell killing effect of middle dose group and high dose group had no differences; (2) salivary gland function: compared with control group, UI and SR in bilateral parotid and bilateral submandibular glands of low dose group, middle dose group and high dose group decreased; salivary gland damage effect of low dose group and middle dose group were weaker than that of high dose group, and salivary gland damage effect of low dose group and middle dose group had no differences.Conclusion:Middle dose of iodine 131 can take the killing effect on cancer cells and the protective effect on salivary glands into account; it’s an ideal dosage for preoperative iodine 131 internal radiation therapy of thyroid cancer patients.

作者： 刊期： 2015年第11期

Objective:To study the effect of ropivacaine-fentanyl combined with spinal–epidural labor analgesia on maternal serum markers and TXB2/6-Keto-PGF1α proportion.Methods:40 cases of puerperas intending to receive vaginal delivery in our hospital were randomly divided into two groups. Combined group received fentanyl subarachnoid injection combined with ropivacaine epidural injection and control group received fentanyl combined with ropivacaine epidural injection. Then levels of serum pain mediators and inflammation related factors as well as TXB2/6-Keto-PGF1α proportion of both groups were detected. Results:In delivery process, contents of serum pain mediatorsβ-EP, NO, SP, PGE2, TNF-α, IL-6, CCL2 and CCR2 of combined group were significantly lower than those of control group, and IL-10 and TGb-βcontents were significantly higher than those of control group; In and after labor, serum TXB2 content and TXB2/6-keto-PGF1α proportion of combined group were lower than those of control group, while 6-keto-PGF1α content was higher than that of control group.Conclusion:Ropivacaine-fentanyl combined with spinal–epidural labor analgesia can achieve more precise analgesia effect, reduce contents of pain mediators, pro-inflammatory cytokines and chemokines, and regulate TXB2/6-Keto-PGF1ααbalance.

作者： 刊期： 2015年第11期

Objective: To explore the effect of different anesthesia and analgesia methods on the T lymphocyte subsets, cytokines and the levels of the stress hormone in patients with breast cancer surgery.Methods: 86 cases of breast cancer were divided into two groups by random digits table, control group of 43 cases with total intravenous anesthesia, and the observation group of 43 cases with total intravenous anesthesia combined with epidural anesthesia and postoperative underwent analgesia. The T lymphocyte subsets, cytokines and the levels of the stress hormone were detected before and after operation and compared. Results:CD3+, CD4+ and CD4+/CD8+ of the two groups at T1 or T2 were significantly lower than those at T0, and those in the observation group were significantly lower than the control group, and the difference between the two groups has statistical significance. IL-6, CRP and TNF-α levels of the two groups at T1, T2 or T3 were significantly higher than those at T0, and those in the observation group were significantly lower than the control group, and the difference between the two groups has statistical significance. Each index of two groups at T4 were restored to T0, and the differences were no statistically significant. The cortisol levels of two groups at T1 or T2 were significantly increased compared with T0, and the increase in the observation group was less than that of the control group, the difference between the two groups has statistical significance. The cortisol levels of two groups at T4 were restored to T0, and the differences were no statistically significant.Conclusion:Epidural analgesia after the intravenous anesthesia combined with epidural anesthesia for breast cancer cure patients has lighter immunosuppression and stress reaction, has less influence on inflammatory factors, is an ideal anesthesia and analgesia.

作者： 刊期： 2015年第11期

Objective:To detect serum chemokine RANTES content in patients with acute coronary syndrome and analyze its relationship with degree of inflammation and myocardial injury. Methods:116 cases of acute coronary syndrome (ACS) patients treated in our hospital from July 2012 to July 2014 were chosen as study group and divided into low-risk group (48 cases), moderate-risk group (33 cases) and high-risk group (35 cases) according to risk stratification; 109 cases of healthy people receiving physical examination during the same period were enrolled in healthy control group. Serum RANTES contents as well as levels of inflammatory cytokines and myocardial injury indicators in all groups were compared and the correlation was further analyzed.Results:Serum RANTES contents as well as levels of inflammatory factors and myocardial injury markers in ACS patients were all significantly higher than those in control group (P<0.05), and with the increase of coronary risk stratification, serum RANTES contents as well as levels of inflammatory factors and myocardial injury markers further rose (P<0.05); serum RANTES contents in ACS patients were positively correlated with levels of inflammatory cytokines and myocardial injury indicators.Conclusion: Increased levels of serum RANTES is one of the important factors contributing to the occurrence of ACS; it is positively correlated with levels of inflammatory cytokines and severity of myocardial injury in patients, and can guide clinical treatment and judge prognosis.

作者： 刊期： 2015年第11期

Objective:To discuss the clinical value of Serum TSH combined with 3 kinds of VEGF (VEGF-C, VEGF-D and VEGFR-3) determination in the early diagnosis of papillary thyroid carcinoma (PTC). Method:Selected 37 cases of patients with thyroid benign tumor (Benign group) and 37 cases of patients with PTC (PTC group), then collected the serum of these both groups, to determine the TSH, VEGF-C, VEGF-D and VEGFR-3 levels of all cases by chemiluminescence immunoassay and enzyme linked immunosorbent assay respectively. Through Logistic model, to calculate the curve area of TSH combined with 3 kinds of VEGF.Results:PTC group: VEGF-C, VEGFR-3 and TSH levels were obviously higher than that in Benign group (P<0.05); and VEGF-C, VEGFR-3 and TSH levels inⅢ-Ⅳ period patients were obviously higher than that in I-Ⅱ period patients (P<0.05); AUC area of VEGF-C, VEGFR-3 and TSH were respectively 0.805, 0.736 and 0.710, reached to significance level (P<0.05); AUC area of combined diagnosis was 0.859.Conclusion:VEGF-C, VEGFR-3 and TSH between papillary thyroid carcinoma and thyroid benign tumor had significant difference. Combined determination could improve the early diagnose rate of PTC, and could be regarded as one of the important auxiliary index of PTC early diagnosis.

作者： 刊期： 2015年第11期

Objective:To explore the feasibility and effectiveness of 64 slice spiral CT in evaluating the patency of coronary artery after stent implantation.Methods:The 64 slice spiral CT image data of 125 patients after coronary artery stent implantation were collected, meanwhile, the image data of 25 patients underwent coronary angiography were also collected. The feasibility and accuracy of 64 slice spiral CT coronary artery stent imaging were comparatively analyzed. Results: The 64 slice spiral CT imaging quality with a stent diameter greater than 3.00 mm was significantly superior to that with a diameter of 2.25-3.00 mm. The CT imaging quality in the left main coronary artery and anterior descending artery was significantly higher than that in the left circumflex coronary artery. The CT imaging quality in the left main coronary artery was significantly higher than that in the right coronary artery. The CT reconstruction imaging quality in the drug coating stent was significantly superior to that in the bare metal stent. The sensitivity of 64 slice spiral CT was 100.00%, and the accuracy was 100.00%. In detecting the coronary artery with occlusion and stenosis (stent stenosis greater than 50%), the sensitivity was 90.00%, the false negative rate was 10.00%, and the positive predicative value was 100.00%.Conclusions:The effect of 64 slice spiral CT coronary imaging in evaluating the patency of coronary artery after stent implantation is highly consistent with that by coronary angiography, with a simple operation, less risk, and low cost, and thus, it can be completely taken as the imaging method in evaluating the patency of coronary artery after stent implantation.

作者： 刊期： 2015年第11期

Objective:To observe and analyze the change situation of immune indexes and oxidative stress state of children with recurrent respiratory tract infection.Methods:75 children with recurrent respiratory tract infection in our hospital from January 2014 to June 2015 were selected as observation group, 75 healthy children with health examination at the same time were selected as control group, then the immune indexes and oxidative stress state related serum indexes of two groups were detected,and the detection results of observation group with boys and girls, mild, moderate and severe disease were compared.Results: The cellular immune and erythrocyte immune and oxidative stress state related serum indexes of observation group were all worse than those of control group,and the detection results of observation group with mild, moderate and severe disease had obvious differences too, allP<0.05, while the differences of boys and girls had no significant differences, allP>0.05.Conclusion:The change of immune indexes and oxidative stress state of children with recurrent respiratory tract infection are obvious,and the differences of children with mild, moderate and severe disease are obvious too,while the differences of boys and girls are not obvious.

作者： 刊期： 2015年第11期