学术投稿

氟西汀对脑卒中抑郁患者不同时期神经功能康复的作用

程丰;邵国富;包仕尧

关键词:抑郁障碍 /康复, 脑血管意外, 氟西汀, 治疗结果, 随机对照试验
摘要:目的:探讨氟西汀抗抑郁治疗对卒中后抑郁( Post Stroke Depression, PSD)患者神经功能康复的影响.方法:选取经临床体格检查、头颅 CT或 MRI确诊的急性脑卒中患者 132例(脑梗死 78例,脑出血 54例).将符合 DSM Ⅳ抑郁症诊断标准的脑卒中患者随机分成抑郁治疗组和抑郁对照组,治疗组予氟西汀治疗.分别在病程 2周、1月、3月、6月、12月时给每一位入组患者行神经功能缺损评分( SSS)、日常生活能力评分( ADL)、汉密尔顿抑郁量表( HAMD)、 Zung's抑郁自评量表( SDS)和焦虑自评量表( SAS)评分.结果:脑卒中患者中约 44.7%出现抑郁症状;抗抑郁药物 PROZAC(盐酸氟西汀)能明显改善病程 3, 6月时神经功能缺损,病程 12月时不仅抑郁症状减轻, ADL能力改善,神经功能缺损减轻尤为显著.结论:抗抑郁治疗能使 PSD患者抑郁症状明显改善的同时,显著提高 ADL能力和神经功能.
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中国组织工程研究杂志

中国组织工程研究杂志

主管:中华人民共和国卫生部

主办:中国康复医学会,《中国组织工程研究与临床康复》杂志社