陈丽捷
目的:观察垂体腺苷环化酶激活肽(pituitaryadenylatecyclaseactivatingpolypeptide,PACAP)对缺血再灌注脑神经元凋亡的防治作用.方法:利用四血管结扎法,建立老龄大鼠脑缺血再灌注模型,侧脑室注射PACAP,观察脑组织丙二醛(MDA)含量和超氧化物歧物酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)活性,计数海马CA1区存活和凋亡神经元数目,电镜观察神经元的超微结构变化.结果:PACAP治疗后脑组织MDA含量为(1.35±0.39)nmol/mg,SOD和GSHPx活性分别为(115±20)NU/mg、(10.3±2.0)U/mg,与缺血再灌注组有明显差异(P<0.05),海马CA1区存活和凋亡神经元数目为48.8±4.3,14.3±2.9,能促进神经元存活和减轻凋亡损伤(P<0.01),保护超微结构.结论:PACAP的保护作用可能与其降低脑组织氧自由基水平,提高抗氧化酶活性,防止神经元凋亡有关.
作者：刘宪霜；崔旭；王鲁宁；李文彬；韩志涛；尹志奎；房征宇 刊期： 2003年第01期
BACKGROUND:Incidence of atherosclerosis was higher in patients with diabetes.Atherosclerosis of peripheral limbs mainly affect artery of lower limbs and abnormal feeling of foot and intermittent limping was the manifestation.
作者：孙丽平；侯水珍；范铁钊；肖运强 刊期： 2003年第01期
在康复医学领域如何开展循证医学?循证医学证据的分级,实践循证医学的步骤,以及怎样才能够通过临床医师参与和利用Cochrane协作网、阅读和应用循证医学文献来寻找到目前好的证据,以解决患者的实际问题;循证医学应用于心肺疾患、神经系统疾患、骨关节疾患等已取得较好的经济效益和社会效益;而目前的部分系统评价所收集的原始文献尚不充分,大部分缺乏大型、多中心随机对照试验的支持,有的系统评价无法得出对临床有帮助的结论.文章综述了康复科主要相关疾病的循证医学研究概况,为临床康复医师如何实践循证医学和进行康复医学科研提供参考.
作者：何成奇；丁明甫 刊期： 2003年第01期
BACKGROUND:The disablement rate of patients after stroke remains high,which perhaps is associated with the factor that many patients cannot get timely and reasonable rehabilitation treatment and the factor that some medical staff pay attention to treatment but ignore early rehabilitation treatment.
作者：邹菊培；杨颖 刊期： 2003年第01期
0 引言婴幼儿早期是学习语言的关键时期,在此时期轻度听觉功能障碍也可能导致小儿心理和行为交往方面的缺陷.因此婴幼儿早期听力测试的准确性直接影响到听力障碍的诊断,从而进一步影响到有听力障碍的婴幼儿今后治疗与康复训练.
作者：姜苏敏 刊期： 2003年第01期
0 引言海水浴是一项多疗养因子协同作用,涉及身体多系统多脏器的良好健身运动.
作者：赵明国；邓群英；李勇 刊期： 2003年第01期
0 引言失眠不但加重原有的精神疾病,而且影响患者的工作和学习效率,特别是与记忆,计算和逻辑推理有关的精神活动,情绪沮丧、焦躁,进而影响人际关系.
作者：张淑兰；安俊峰；林桂梅；李银霞 刊期： 2003年第01期
组织化卒中医疗是指多学科的、合作的和整合的医疗计划,目的是提供给患者佳医疗服务.佳医疗服务包括高质量、标准化、有效的和花费效果合适的措施.组织化卒中医疗的基本文件是卒中指南和整合医疗路径.组织化卒中医疗的项目和形式包括欧洲的卒中单元、美国的卒中中心、加拿大阶梯工程和北京组织化卒中医疗体系.
作者：王拥军 刊期： 2003年第01期
1 心力衰竭患者运动耐力下降的原因慢性心力衰竭是心肌梗死及其他慢性疾病(如未发生梗死的缺血性心脏病、高血压、各种感染、毒物代谢及内分泌紊乱)共同的结局.
作者：朱起东；史长河；张喜明 刊期： 2003年第01期
INTRODUCTIONThere are many causes of epilepsy and stroke is the common reason of delayed epilepsy especially after formation of throbosis and multiple lacunar cerebral infarction[1].
作者：黎朝茂 刊期： 2003年第01期
0 引言甲状腺功能亢进(甲亢)的发生与日常生活密切相关,急剧的生活变更、亲人亡故、情感刺激、竞争激烈等心理、环境因素对其发生,发展及其转归,具有重要影响.
作者：罗俊敏 刊期： 2003年第01期
0 引言以往在面神经炎恢复期采用物理治疗因子超短波、磁疗、针灸等,临床见效较慢,采用特定电磁波治疗仪 (TDP)与硝酸士的宁综合治疗面神经炎,目的在于提高临床治疗效果.
作者：田雅萍；兰怡；张炜；刘国润；高文莉 刊期： 2003年第01期
BACKGROUND:Dysphagia is the common complication in stroke,often leads to nutrition deficiency,asparition pneumonia,cated reduce patients'living confidence that will influence entiretherapeutic course.
作者：刘连凯 刊期： 2003年第01期
AIM:To observe the effect of the antibody of brain derived neurotrophic factor(BDNF) by cortical microinjection on hippocampal ischemic injury rats.METHODS:Preparation of local cerebral ischemic reperfusion injury model: cortical stereostaxic approach, microinjection of BDNF antibody. Applied immunohistochemical method to observe distribution of BDNF in cortex after injection of the antibody,to observe the alteration of ischemic injury between control group and BDNF antibody group.RESULT: The volume of cerebral infarction in BDNF antibody group was larger than control group.CONCLUSION: BDNF has protection function for cerebral ischemia.
作者：陈英辉；王根发；陈兴华；姚革；陈伟；周永炜 刊期： 2003年第01期
BACKGROUND:Cervical vertigo(CV) belongs to vertebral artery type of cervical spondylopathy which clinical manifestation was paroxysmal vertigo and is highly related to cervical motion.Recent clinical experiences proved that comprehensive treatment was superior to simple treatment.Because of patients were in different departments,therapeutic methods were also different,effects produce slowly,remote effects were not obvious and recurrence rate was higher.
作者：曾西；陈尚康；关晨霞；彭予忠；姜丽 刊期： 2003年第01期
作者： 刊期： 2003年第01期
INTRODUCTIONDifficulty in opening mouth is one of the severe reactions,which can affect reaction patient's existence quality severely[1- 5].Now,it is thought to be helpful for preventing difficulty in opening mouth caused by radiation by early rehabilitation training.Our research results are reported as following.
作者：朱巧凤 刊期： 2003年第01期
0 引言新生儿缺氧缺血性脑病(HIE)是指在围产期窒息导致脑的缺氧缺血性损伤.
作者：陈虹；王倩；黄瑞兰 刊期： 2003年第01期
INTRODUCTIONBrachium potine syndrome is also called potine cerebellum lesion syndrome,is localized at facial, acoustic,trigeminal and vestibule nerve roots.In clinic,lesion in this zone is rare.We met two cases recently. Both of cases were acute onset, with hypertension history. First symptoms were dizziness, unstability of gait,facial hemianesthesia, corneal reflex dullness,poor hearing and dystaxia.Cerebral MRI showed brachium potine with long T1 and T2, signal of focus with clear margin,enhance scan showed slight or apparent reinforcement.To determine in what degree to treat them and how to use method of evidence based medicine to determine their diagnosis and best therapy,we spent less than 3 hours on searching and gaining evidences through computer of provincial medical information center.
作者：林岚；翟明 刊期： 2003年第01期
0 引言糖尿病合并抑郁症的患者并不罕见,抑郁症可引起血糖控制不良和治疗配合程度下降,故应引起重视.
作者：陈超 刊期： 2003年第01期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
