刘卫民；袁海斌；黄笑；周雪娇
INTRODUCTION Sleep- wake rhythm is isolated from day- night rhythm of natural world;Sleep depends on the regulation of special structure of central nerve system and correlated neurotransmitters.This paper mainly introduces the research progress of neurotransmitter correlated to sleep.It benefits the comprehension of physiology,pathology and pharmacology of sleep and recognition of sleep.
作者：初建平；孟昭义 刊期： 2003年第07期
目的吸毒者心血管系统受毒品损害已有许多研究,为了获取更多信息,对相关指标进行统计分析.方法 19例吸毒者和 20例健康自愿者进行了 1/4全运动量 (1/4)下的心音图运动试验.同时记录心肌收缩能力和心动周期信号.把运动后第一心音( S1)幅值对安静时 S1幅值的增加倍数定义为心力变化趋势 (Cardiac Contractility Change Trend, CCCT).结果吸毒者的 CCCT(1/4)为 3.51± 2.05, 20例健康自愿对照者的 CCCT(1/4)为 7.21± 3.40, 吸毒者与健康对照组的心力变化趋势差异有非常显著性意义( P< 0.01).结论调查研究表明,这一方法适于对吸毒者的心肌收缩能力和心力储备作量化测试和评估.调查研究所得数据有利于向吸毒者和公众警示吸毒带来的严重后果.
作者：潘传中；李俐君；杨支国；刘千业；王宇虹；肖守中 刊期： 2003年第07期
INTRODUCTION Knee osteoarthritis is a regenerated change of knee hyaline cartilage, complicated with bone hyperplasia,synovitis and articular capsule and muscle changes due to old age and knee joint injury, deformity and diseases etc factors.Osteoarthritis induced many clinical manifestations including knee ache,swelling and limited motion and seriously affected the quality of the patients'.
作者：徐振奇；姜贵云；刘旭东；柴叶红；李青 刊期： 2003年第07期
INTRODUCTION Cerebral trauma is a kind of injury of skull and brain induced by out force struck.Except the direct injury of skull and cerebral tissue, secondary injury such as intercranium hematom,cerebral edema and increased intracranial pressure always occurred.Sometimes,with compliance of fracture of cervical vertebra and spinal cord,peripheral nerve injury.If synthetic rehabilitation methods were used, good effect can be detected.
作者：唐梅 刊期： 2003年第07期
目的观察大鼠永久性大脑中动脉阻塞( pMCAO)后,相应区域 DNA断裂损伤情况,探讨 DNA单链损伤在 pMCAO所致脑组织损伤中的意义.方法采用常规 HE组织染色明确大鼠 pMCAO模型成功与否及其损伤范围,采用 DNA聚合酶- 1 Klenow片段原位杂交方法检测 pMCAO不同时间点 DNA单链断裂损伤情况.结果损伤区域单链 DNA断裂的 Klenow阳性细胞在 pMCAO后 6 h即有表达( P< 0.01),在 24 h时达到高峰( P< 0.01), 72 h时有所下降( P< 0.01).结论单链 DNA断裂损伤在 pMCAO后 6 h即可出现,并逐渐积累,成为缺血半暗带内细胞损伤发展过程的重要环节,并可能预示半暗带损伤范围的不断扩大.
作者：万琪；张巍；刘勇红 刊期： 2003年第07期
INTRODUCTION It is reported 70%- 90% patients show dementia psychology and behavior in patients with aging dementia (AD),which are the main causes of hospitalization.Others can not understand AD patients who also can not understand the other persons affecting quality of nursing.So,to comprehend communication skills,to support them menally are very important for improvement of AD patients' quality of life.
作者：欧正红；黄丽葵；卢玉贞；孔容冰；马超 刊期： 2003年第07期
目的研究碱性成纤维细胞生长因子 (basic fibroblast growth factor, bFGF)在大鼠短暂大脑中动脉阻塞 (MCAO)再灌注后不同时点表达的变化,进一步探讨 bFGF对局灶性脑缺血的脑保护作用,为治疗缺血性脑血管病提供实验基础和依据.方法采用栓线法 MCAO动物模型 ,通过免疫组化方法观察 bFGF的表达情况.结果免疫阳性细胞主要在神经元和神经胶质细胞中的表达, bFGF在缺血再灌注后 6 h开始表达 ,1 d时达高峰 ,3 d时开始下降 , 7 d时有少量表达.结论短暂 MCAO后 bFGF表达上调 ,提示 bFGF的表达增加对缺血脑组织有保护作用.
作者：王静娥；张朝东 刊期： 2003年第07期
BACKGROUND:Motor obstacle of limbs directly resulted from hemiplegia after stroke seriously affect patients′ daily work and living.Conventional medicine treatment can improve the function of hemiplegic limbs at some degree, but more and more studies confirm that conventional acupuncture therapy is an effective method to improve motor function of limbs.By point stimulating channel system, acupuncture therapy can regulate qi and smooth channel system, thus regulate whole body to achieve the goal of curing hemiplegia. Acupuncture combined with hyperbaric oxygen therapy can accelerate regeneration of cerebral cells, and promote the recovery of motor function of paralyzed limbs.
作者：张志刚；孙毓 刊期： 2003年第07期
BACKGROUND:During the therapy of cencers,it is difficult to continue chemiotherapy due to frequent vomiting,especially commonly used drugs such as side effects of cisplatin.Although new pharmacy appeared in greatly relieve vomiting effect of the chemiotherapy, there were no satisfied drugs to settle this problem.
作者：王中华；陈冬波 刊期： 2003年第07期
BACKGROUND:Temporomandibular disorders ( TMD) included a group of clinical symptoms and disorder of masticate muscle group and temporomandibular joint,while its causes are not clear.TMD is characterized by pain around temporomandibular joi nt,sanp,and movement disorder in mandible,Currently,it is generally accepted that multiple factors resulted in TMD,including mental and psychological,muscular and tooth factors.Comprehensive treatment rather than single treatment is suggested for TMD.
作者：黄昊红；徐文华；李佐强；韩永红 刊期： 2003年第07期
目的:探讨 4种多巴胺递质相关基因 COMT, DBH, DAT1 和 MAOB的多态性与上海地区居民帕金森氏病的易感性的关系.方法:用聚合酶链式反应和限制性片段长度多态性( PCR/RFLP)技术检测 4种多巴胺能递质代谢相关基因多态性,对 144名原发性帕金森病病人和年龄相匹配的 188名健康人进行相关性分析.结果:与健康人相比,帕金森病患者 DBH 基因型或等位基因的分布不同,两组之间的差异有统计学意义.结论: DBH多态性在中国汉族人帕金森氏病的易感性中可能起作用.
作者：赵晓萍；谢惠君；汤国梅；赵武伟；徐玲；林大宇；朱琪泉；苏敬敬；韩海雄；郝怡鑫；兰和魁；王荫榆；任大明 刊期： 2003年第07期
INTRODUCTION Inflammatory reaction induced by cell immunology is the important mechanism of neuron injury, degenertion and progressive necrosis during ischemia- reperfusion course[1- 2].Human leucocyte antigen- II(HLA- II) is mainly expressed by presenting antigen presenting cell(APC).While HLA- DR antigen expressed mainly on the activated T cells and had a highly specificity and played an important role in immunology reaction and immunology adjustment[2].In our experiment,we explored research in CD3/CD(16+ 56) and CD3/HLA- DR by employing monocolonel antibody and immunology fluorescent labeling and FCM technology.
作者：谭峰；顾卫；黄涛；王金良；吴海科；黄彪 刊期： 2003年第07期
目的言语测听在助听器的选配中有决定性的作用,中国临床应用较少,通过言语测听了解耳内式助听器和耳背式助听器的使用者在言语分辨率的差别.方法采用开放法和闭合法 ,分别对耳内式、耳背式助听器使用者,进行单耳聆听条件下的言语测试.言语信号类型选用单音节词和双音节词,每耳测听单音节词和双音节词各为 20个.结果耳内式、耳背式助听器使用者的使用效果相比,在言语分辨率上无论开放式、闭合式对双音节词、单音节词的分辨率无显著性差异( P >0.05);双音节词和单音节词的分辨率比较,开放式的状态下,有显著性差异( P< 0.05);闭合式的状态下,无显著差异( P >0.05).结论在助听器的选配中言语测听的实际实施受诸多因素的影响.
作者：高建林；杨月珍；梁晨；王晓阳；吴竹梅；杨丽 刊期： 2003年第07期
MATERIALS AND METHODS Materials 18 cases females in our group had mental symptoms to various degree before and after operation,with age ranging from 38 to 51 years. There were 16 cases of psychological dependence before operation and 4 cases after operation.There were 1 case of Paranoia before operation and 8 cases after operation. There were 4 cases of delirium after oparation and 1 case of other type before operation and 2 cases after operation.All the patients were excluded space occupying lesion by head CT.
作者：李秀香；邵林萍；刘广庆 刊期： 2003年第07期
AIM:To study the relationship between post- stroke dizziness and psychological factors.METHODS:To choose 82 cases with dizziness after stroke. The patients whose medical treatment were invalid were divided into two groups randomly.The experimental group of 43 cases was treated with antipsychotic and the controls group of 39 cases was treated with consolation.RESULTS:The total effective rate in experimental group was significantly higher than that in the control group(P< 0.001).CONCLUSION:It is suggested that though the mental scales scores might be normal, post- stroke dizziness should be treated for a long- term helplessly be just a sign of psychological matter.It ought to be discerned and given pertinent treatments.
作者：何晓军；张沙丽；马敏敏；张传文 刊期： 2003年第07期
INTRODUCTION 856 cases of severe trachoma were treated from May 1984 by freezing combined with drugs,the effects were satisfying.
作者：于亚东；张东航；王永毅 刊期： 2003年第07期
目的神经干细胞体外培养的成功是进一步研究其分化机制的基础 ,从胚胎大鼠脑室下区分离、培养、鉴定神经干细胞 (neural stem cells,NSCs),并观察其向神经元的分化情况.方法分离胚胎 SD大鼠脑室下区的组织,采用无血清原代及传代培养方法,获得具有克隆能力的细胞群;应用免疫细胞化学方法鉴定神经干细胞并检测分化后特异性成熟神经细胞抗原的表达;应用流式细胞检测技术观测神经干细胞随时间向神经元的分化情况.结果从胚胎大鼠脑室下区分离培养的细胞群具有克隆增殖能力,表达神经上皮干细胞蛋白( nestin),分化后的细胞表达神经元、星形胶质细胞和少突胶质细胞的特异性抗原;随着贴壁后分化时间的延长,表达 nestin的细胞数量从 80.5%下降到 10.9%,而神经元特异性烯醇化酶( neuron specific enolase,NSE)阳性细胞数量则从 1.1%上升到 31.6%.结论用本方法分离的细胞具有自我更新和增殖能力,并具有多分化潜能,是中枢神经系统的干细胞;随着分化时间的延长,神经干细胞数量下降,而神经元比例有明显上升.
作者：张瑞国；万琪；李力；俞英欣；曹云新 刊期： 2003年第07期
目的通过生育年龄吸毒女性及自愿受检非吸毒正常女性,从下丘脑生殖轴、外周血女性相关激素水平及临床症状体征 3个水平进行对比研究,以探讨长期使用海洛因对女性生殖系统的损害.方法填写调查表、对患者进行相关体检,抽血进行女性激素检测、阴道细胞涂片查雌激素影响程度或卵巢功能低下情况、妇科彩色 B超测量子宫及其内膜和卵巢大小.结果吸毒组促性腺激素释放激素( GnRH)、雌二醇( E2) 、孕酮( P)明显低于正常组,而卵泡刺激素( FSH)、黄体生成素( LH)相反明显高于正常组( P< 0.01及 < 0.05);与正常组比,吸毒组阴道雌激素水平降低、而阴道 pH值升高( P< 0.05);皮下脂肪减少、子宫、子宫内膜、卵巢、乳房、脂肪、大阴唇等明显萎缩( P< 0.05或 P< 0.01);另吸毒组多数显现月经紊乱、停经或闭经.结论长期使用海洛因可通过抑制生殖轴、抑制排卵及卵巢功能等途径,对女性生殖系统造成明显损害.长期吸毒可致卵巢功能减退甚至衰竭危险.
作者：严海燕；杨仁美；木兆慈；张秋红；李鹏；赖宏芳；杨一平；程玲；孙杏娟；王平华；李娜；骆跃 刊期： 2003年第07期
MATERIALS AND METHODS Materials 42 cases of female patients were client from hospital,with age ranging from 38 to 55 years(average 46 years).Disease course was franging from 0.5 to 6.0 years.
作者：谢珍 刊期： 2003年第07期
INTRODUCTION Patients in rehabilitation department were mostly transferred from internal neurology department.With short course and stalbe conditions,if the patients were treated with on time and activated routine rehabilitation therapy,nerve cells not injured can establish normal connections and cause rehabilitation of the hemiplegia extremities and reduce or eliminated the disable degree of the patients.
作者：尹虹；田玉波 刊期： 2003年第07期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
