杨晓娟；李凯；何韬
目的研究新生大鼠缺氧缺血时脑内血红素氧化酶- 1( HO- 1)和内源性一氧化碳( CO)及环化鸟苷酸( cGMP)的变化,探讨锌原卟啉( Znpp)的治疗作用.方法 7 d SD大鼠随机分为假手术对照组,缺氧缺血组( HI)及缺氧缺血+锌原卟啉组( HI+ Znpp).利用分光光度法测定血 COHb含量和脑匀浆 HO- 1活性;放免法测定脑匀浆 cGMP水平,并观察脑病理改变.结果 HI组在 1, 4, 12 h HO- 1、 cGMP、 CO水平与对照组比明显升高( P< 0.01),在 12 h达到高峰; HI+ Znpp组 HO- 1、 cGMP、 CO水平在 1, 4, 12 h均明显低于 HI组( P< 0.01),但仍高于对照组( P< 0.01).脑组织病理检查可见 HI组呈重度缺氧缺血改变,多数神经元细胞肿胀变性;而 Znpp组神经元变性者少.结论 HI后脑内 HO- 1活性明显增高导致内源性 CO和 cGMP增高, Znpp可阻抑这一病理生理过程,减轻脑损伤.
作者：王玲；张薇；惠延平 刊期： 2003年第07期
BACKGROUND:Temporomandibular disorders ( TMD) included a group of clinical symptoms and disorder of masticate muscle group and temporomandibular joint,while its causes are not clear.TMD is characterized by pain around temporomandibular joi nt,sanp,and movement disorder in mandible,Currently,it is generally accepted that multiple factors resulted in TMD,including mental and psychological,muscular and tooth factors.Comprehensive treatment rather than single treatment is suggested for TMD.
作者：黄昊红；徐文华；李佐强；韩永红 刊期： 2003年第07期
BACKGROUND:During the therapy of cencers,it is difficult to continue chemiotherapy due to frequent vomiting,especially commonly used drugs such as side effects of cisplatin.Although new pharmacy appeared in greatly relieve vomiting effect of the chemiotherapy, there were no satisfied drugs to settle this problem.
作者：王中华；陈冬波 刊期： 2003年第07期
INTRODUCTION Xingding is a compound agent of the fourth edition extract of ginkgo leaf,with addtion of agacore.Its main ingradient are ginkgo seed flavonoid glycoside(24% ), ginkgo seed lactone(3% ),bilobalide(3% ) and agacore(10% ).With ginkgo leaf acid smaller than 5× 10- 6,many clinical and basic research prove it has many biological effects.
作者：雷显泽；周妮；黄良国 刊期： 2003年第07期
BACKGROUND:Therapy with block needle knife can block pain conduction pathway and prevent vicious cycle of pain, improve blood cirvulation and enhance inflammatory.With the help of needle knife, adhesion, keloid and muscles spasmed can be cut and isolated to active equilibarium of muscles around joints.
作者：张庆君；魏斌 刊期： 2003年第07期
作者： 刊期： 2003年第07期
INTRODUCTION:Shoulder- hand syndrome(SHS) also called reflective sympathetic malnutrition is a common syndrome and often seen in stroke paralysis,which early manifestation is sudden edema of hand,pain,increased skin temperature,shoulder pain.If treatment is prolonged,muscle atrophy of hand and permanent loss of range of movement might occure.Comprehensive rehabilitation treatment has a good effect on SHS.In this article,effect of block of ganglion stellatum on SHS is observed on base of comprehensive rehabilitation treatment.
作者：曾西；陈尚康；关晨霞；姜丽；王留根 刊期： 2003年第07期
INTRODUCTION Patients in rehabilitation department were mostly transferred from internal neurology department.With short course and stalbe conditions,if the patients were treated with on time and activated routine rehabilitation therapy,nerve cells not injured can establish normal connections and cause rehabilitation of the hemiplegia extremities and reduce or eliminated the disable degree of the patients.
作者：尹虹；田玉波 刊期： 2003年第07期
目的观察大鼠永久性大脑中动脉阻塞( pMCAO)后,相应区域 DNA断裂损伤情况,探讨 DNA单链损伤在 pMCAO所致脑组织损伤中的意义.方法采用常规 HE组织染色明确大鼠 pMCAO模型成功与否及其损伤范围,采用 DNA聚合酶- 1 Klenow片段原位杂交方法检测 pMCAO不同时间点 DNA单链断裂损伤情况.结果损伤区域单链 DNA断裂的 Klenow阳性细胞在 pMCAO后 6 h即有表达( P< 0.01),在 24 h时达到高峰( P< 0.01), 72 h时有所下降( P< 0.01).结论单链 DNA断裂损伤在 pMCAO后 6 h即可出现,并逐渐积累,成为缺血半暗带内细胞损伤发展过程的重要环节,并可能预示半暗带损伤范围的不断扩大.
作者：万琪；张巍；刘勇红 刊期： 2003年第07期
目的通过生育年龄吸毒女性及自愿受检非吸毒正常女性,从下丘脑生殖轴、外周血女性相关激素水平及临床症状体征 3个水平进行对比研究,以探讨长期使用海洛因对女性生殖系统的损害.方法填写调查表、对患者进行相关体检,抽血进行女性激素检测、阴道细胞涂片查雌激素影响程度或卵巢功能低下情况、妇科彩色 B超测量子宫及其内膜和卵巢大小.结果吸毒组促性腺激素释放激素( GnRH)、雌二醇( E2) 、孕酮( P)明显低于正常组,而卵泡刺激素( FSH)、黄体生成素( LH)相反明显高于正常组( P< 0.01及 < 0.05);与正常组比,吸毒组阴道雌激素水平降低、而阴道 pH值升高( P< 0.05);皮下脂肪减少、子宫、子宫内膜、卵巢、乳房、脂肪、大阴唇等明显萎缩( P< 0.05或 P< 0.01);另吸毒组多数显现月经紊乱、停经或闭经.结论长期使用海洛因可通过抑制生殖轴、抑制排卵及卵巢功能等途径,对女性生殖系统造成明显损害.长期吸毒可致卵巢功能减退甚至衰竭危险.
作者：严海燕；杨仁美；木兆慈；张秋红；李鹏；赖宏芳；杨一平；程玲；孙杏娟；王平华；李娜；骆跃 刊期： 2003年第07期
INTRODUCTION With aging of population structure and small- size of family structure the need of senile patients on long- term rehabilitation serves increases,which greatly improve and propel the development of rehabilitation nursing of senile people in domain of nursing speciality. The assessment of need of senile people on long- term nursing and knowing about available service items of senile nursing of community and on what extent the items satisfying providing massage and foundation for senile nursing are urgently needed from the levels of body, psychology and social support through social investigation,which also can provide reference about plan and policy for managers of senile health serve system.
作者：苗文哲；姜万梅；赵薇；姜艳滨 刊期： 2003年第07期
MATERIALS AND METHODS Materials 18 cases females in our group had mental symptoms to various degree before and after operation,with age ranging from 38 to 51 years. There were 16 cases of psychological dependence before operation and 4 cases after operation.There were 1 case of Paranoia before operation and 8 cases after operation. There were 4 cases of delirium after oparation and 1 case of other type before operation and 2 cases after operation.All the patients were excluded space occupying lesion by head CT.
作者：李秀香；邵林萍；刘广庆 刊期： 2003年第07期
MATERIALS AND METHODS Materials 2 cases were diagnosed as arrhythmia without clear reasons by ECG and were confirmed that they didn't suffered organic diseases.All the cases received anti- arrhythmia and heart muscle nutrition drugs and didn't gain good effects.
作者：林绵辉；陈镇荣 刊期： 2003年第07期
AIM:To estimate the prognosis of Bell palsy.METHODS: Blink reflex (BR), electromyography(EMG),motor latency(ML) and amplitude (AMP) of facial nerve were performed in 42 patients with Bell's palsy.The patients were followed about half a year.RESULTS: (1)When 1 of the 3R waves related with the ill side existed or appeared in 3 weeks after onset,97% patients could recover completely.The recovery time was related to the time of the occurrence of R wave.(2) When 1 of the 3 R waves appeared in the 4th week, 60% patients could recover completely.When none of the 3 waves appeared after the 4th week,100% patients could not recover completely.EMG showed spontaneous activities in 3 of the 6 patients in the 4th week.(3) Motor latency and amplitude of facial nerve were examined when the illness stopped developing.All patients had normal latencies.5 patients' amplitudes reduced more than 90% . 3 of the 5 patients did not appear the related R waves after the 4th week.CONCLUSION:BR might provide the early sign of good prognosis of Bell's palsy. BR together with EMG and ML and AMP of facial nerve might provide the later sign of poor prognosis.
作者：鲍海平；常宇；毛艺芳；尹琳；高政 刊期： 2003年第07期
INTRODUCTION Postcranial- trauma headache is one of the most common symptoms in clinic.The earlier these symptoms are improved the more active effects will be obtained for the patients' recovery and prognosis. `
作者：杜安民；万从容 刊期： 2003年第07期
INTRODUCTION The incidence,handicapping and fatality of cerebrovascular accidence (CVA) are high.Preventing complications and sequela, promoting function recovery, using remaining function adequately and regulating psychic state can promote patients self- care ability.
作者：楚平华 刊期： 2003年第07期
INTRODUCTION Cerebral trauma is a kind of injury of skull and brain induced by out force struck.Except the direct injury of skull and cerebral tissue, secondary injury such as intercranium hematom,cerebral edema and increased intracranial pressure always occurred.Sometimes,with compliance of fracture of cervical vertebra and spinal cord,peripheral nerve injury.If synthetic rehabilitation methods were used, good effect can be detected.
作者：唐梅 刊期： 2003年第07期
运动疗法是根据疾病特点和患者功能情况,借助治疗器械和 /或治疗者的手法操作以及患者自身参与,通过主动和 /或被动的方式来改善人体局部或整体的功能,提高身体素质满足日常生活需求的一种治疗方法.而其利用脑卒中偏瘫特点,根据神经生理学和发育学原理来促进中枢神经系统的功能康复,一般包括 Bobath技术, Rood技术, PNF技术, Brunnstrom技术等,运动疗法是脑卒中偏瘫康复基本手段之一 [1- 2].
作者：孟兆祥；李厥宝；倪朝民 刊期： 2003年第07期
INTRODUCTION Encephalopathy tarda of CO intoxication is the result of incomplete therapy or in- timely treatment of acut intermedium or severe CO intoxication leading to a series of nerve system injury.Due to long period of course,serious condition and unlcrear mechanism,therapy is difficult and poor effect.
作者：杨金华；王金春 刊期： 2003年第07期
BACKGROUND:In China,steroid such as dexamethasone was often used for curing multiple sclerosis(MS),which had definitive effect but was slow in effect and needed a long time for taking medicine,more importantly,had severe side- effect.In recent years,high dose methylprednisolone has achieved some effect on immuno- neurologic diseases.
作者：陈运平；孙圣刚；梅元武 刊期： 2003年第07期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
