目的:探讨 4种多巴胺递质相关基因 COMT, DBH, DAT1 和 MAOB的多态性与上海地区居民帕金森氏病的易感性的关系.方法:用聚合酶链式反应和限制性片段长度多态性( PCR/RFLP)技术检测 4种多巴胺能递质代谢相关基因多态性,对 144名原发性帕金森病病人和年龄相匹配的 188名健康人进行相关性分析.结果:与健康人相比,帕金森病患者 DBH 基因型或等位基因的分布不同,两组之间的差异有统计学意义.结论: DBH多态性在中国汉族人帕金森氏病的易感性中可能起作用.
作者：赵晓萍；谢惠君；汤国梅；赵武伟；徐玲；林大宇；朱琪泉；苏敬敬；韩海雄；郝怡鑫；兰和魁；王荫榆；任大明 刊期： 2003年第07期
对于前庭系统性眩晕,仅靠临床表现来判断病变部位有无器质性损害,容易出差错.应用神经电生理检查,显示电生理改变,是否对临床医生有指导作用?为此,对前庭系统性眩晕患者进行脑干听觉诱电位( BAEP)检测,结合影像学资料及住院观察其转归情况,分析 BAEP的临床应用价值.
作者：吴振东；周宏君；李壮丰；陈汉波 刊期： 2003年第07期
随着 133Xe吸入法测定局部脑血流量( topical cerebral blood flow,rCBF)的检查手段普遍推广应用,采用此法对持续性植物状态( persistent vegetative state, PVS)患者进行 rCBF测定.并对结果进行分析,从而进一步探讨 PVS患者不同病因、病情变化的 rCBF改变情况及机制分析.
作者：吴春平；陈立；马虎龙；王培东 刊期： 2003年第07期
AIM:To estimate the prognosis of Bell palsy.METHODS: Blink reflex (BR), electromyography(EMG),motor latency(ML) and amplitude (AMP) of facial nerve were performed in 42 patients with Bell's palsy.The patients were followed about half a year.RESULTS: (1)When 1 of the 3R waves related with the ill side existed or appeared in 3 weeks after onset,97% patients could recover completely.The recovery time was related to the time of the occurrence of R wave.(2) When 1 of the 3 R waves appeared in the 4th week, 60% patients could recover completely.When none of the 3 waves appeared after the 4th week,100% patients could not recover completely.EMG showed spontaneous activities in 3 of the 6 patients in the 4th week.(3) Motor latency and amplitude of facial nerve were examined when the illness stopped developing.All patients had normal latencies.5 patients' amplitudes reduced more than 90% . 3 of the 5 patients did not appear the related R waves after the 4th week.CONCLUSION:BR might provide the early sign of good prognosis of Bell's palsy. BR together with EMG and ML and AMP of facial nerve might provide the later sign of poor prognosis.
作者：鲍海平；常宇；毛艺芳；尹琳；高政 刊期： 2003年第07期
目的观察大鼠永久性大脑中动脉阻塞( pMCAO)后,相应区域 DNA断裂损伤情况,探讨 DNA单链损伤在 pMCAO所致脑组织损伤中的意义.方法采用常规 HE组织染色明确大鼠 pMCAO模型成功与否及其损伤范围,采用 DNA聚合酶- 1 Klenow片段原位杂交方法检测 pMCAO不同时间点 DNA单链断裂损伤情况.结果损伤区域单链 DNA断裂的 Klenow阳性细胞在 pMCAO后 6 h即有表达( P< 0.01),在 24 h时达到高峰( P< 0.01), 72 h时有所下降( P< 0.01).结论单链 DNA断裂损伤在 pMCAO后 6 h即可出现,并逐渐积累,成为缺血半暗带内细胞损伤发展过程的重要环节,并可能预示半暗带损伤范围的不断扩大.
作者：万琪；张巍；刘勇红 刊期： 2003年第07期
INTRODUCTION 856 cases of severe trachoma were treated from May 1984 by freezing combined with drugs,the effects were satisfying.
作者：于亚东；张东航；王永毅 刊期： 2003年第07期
运动疗法是根据疾病特点和患者功能情况,借助治疗器械和 /或治疗者的手法操作以及患者自身参与,通过主动和 /或被动的方式来改善人体局部或整体的功能,提高身体素质满足日常生活需求的一种治疗方法.而其利用脑卒中偏瘫特点,根据神经生理学和发育学原理来促进中枢神经系统的功能康复,一般包括 Bobath技术, Rood技术, PNF技术, Brunnstrom技术等,运动疗法是脑卒中偏瘫康复基本手段之一 [1- 2].
作者：孟兆祥；李厥宝；倪朝民 刊期： 2003年第07期
BACKGROUND:Therapy with block needle knife can block pain conduction pathway and prevent vicious cycle of pain, improve blood cirvulation and enhance inflammatory.With the help of needle knife, adhesion, keloid and muscles spasmed can be cut and isolated to active equilibarium of muscles around joints.
作者：张庆君；魏斌 刊期： 2003年第07期
作者： 刊期： 2003年第07期
BACKGROUND:In China,steroid such as dexamethasone was often used for curing multiple sclerosis(MS),which had definitive effect but was slow in effect and needed a long time for taking medicine,more importantly,had severe side- effect.In recent years,high dose methylprednisolone has achieved some effect on immuno- neurologic diseases.
作者：陈运平；孙圣刚；梅元武 刊期： 2003年第07期
INTRODUCTION Recovery of normal sexual activity is the rehabilitation objective of patients with myocardial infarction.Guide to sexual activity should not be neglected for patients and their spouses.Health sexual life is necessary for improvement of quality of life and recovery to society.However,traditional culture made nurses and doctors shirk sexual education,patients and their spouses are reluctant to talk the sex to their doctors.Sex life had been neglected.Anxiety and fear for sex can be cleared by special staffs.Nurse,therefore especially circulation nurses should comprehend techniques and knowledge about health education of sex life.
作者：郭宏；姚宏利 刊期： 2003年第07期
目的研究 caspase- 3抑制剂 Ac- DEVD- CMK及 calpain抑制剂 ALLN干预治疗对大鼠局灶性脑缺血 /再灌注模型的神经保护作用.方法经左侧侧脑室注射 DEVD或 /和 ALLN及溶剂二甲基亚砜( DMSO)后,制作大鼠左侧 MCA缺血再灌注模型;缺血 2 h再灌注 24 h进行 TTC染色观察梗死灶的形成情况;并分别于缺血 2 h再灌注 24 h或 48 h检测鼠脑中单、双链 DNA断裂情况.结果溶剂 DMSO预处理组的各项指标与 MCAO模型组无明显差异; DEVD或 ALLN治疗后缺血侧脑中 Klenow及 TUNEL阳性细胞数均明显减少,二者合用作用强.结论 Caspase- 3与 calpain均在缺血性脑损伤中起重要作用,对此进行治疗干预具有潜在的临床应用价值.
作者：王宇卉；卞杰勇；强华；夏春林；邵福源 刊期： 2003年第07期
丘脑出血是脑卒中的一种类型 , 丘脑卒中后肩痛严重影响脑卒中患者的情绪及功能恢复.为探讨磁疗治疗丘脑出血后肩痛疗效,应用磁疗方法治疗丘脑出血后肩痛患者 11例 ,均取得明显疗效 ,提示磁疗法对改善丘脑出血后肩痛有效.
作者：王旭 刊期： 2003年第07期
AIM:Discuss the relationship of pulse pressure and left ventricular function in hypertensive patients.METHODS:We observed the relationship of the pulse pressure and the times of again occurred coronary artery diseases, left ventricular fore and after span, left ventricular back wall thickness and left ventricular ejection fraction(EF) by color Doppler ultrasound in hypertensive patients. RESULTS:The times of again occurred coronary artery diseases, the left ventricular fore and after span and left ventricular EF of each pulse pressure group were significantly difference(P< 0.05, P< 0.01). CONCLUSION:The pulse pressure may take part in the further impair of left ventricular function coronary artery diseases.Control the pulse pressure coronary artery diseases have an important meaning in decreasing the further impair of left ventricular function.
作者：杨文；王浩；刘志发 刊期： 2003年第07期
INTRODUCTION People have paid great attention to how to elevate curative effects and decrease relapse of severe cardiac insufficiency patients in rehabilitation stage.Foreign researches showed that specific health education can enhance patients' self- care ability,ameliorate prognosis and decrease relapse.Our research tried to elevate rehabilitation nurse quality of senile patients through rehabilitation guide of senile severe cardiac insufficiency patients in recovery stage.
作者：罗仕兰；江洁 刊期： 2003年第07期
缝隙连接( gap junction, GJ)是相邻细胞间直接交流胞质成分进行通讯的唯一通道.中枢神经系统神经元间 GJ通讯涉及许多生理及病理的过程,其通道的开-关与神经损伤的修复、癫痫的发作、记忆的形成与再现、肌痉挛的发生等均密切相关.因此,通过了解调节 GJ开-关的诸多因素,阻止神经元损伤的扩延,在神经功能重建时期,开放 GJ通讯促进神经元的重塑具有重要的临床意义.
作者：蒋晓江；李书林 刊期： 2003年第07期
MATERIALS AND METHODS Materials 42 cases of female patients were client from hospital,with age ranging from 38 to 55 years(average 46 years).Disease course was franging from 0.5 to 6.0 years.
作者：谢珍 刊期： 2003年第07期
INTRODUCTION Cerebral trauma is a kind of injury of skull and brain induced by out force struck.Except the direct injury of skull and cerebral tissue, secondary injury such as intercranium hematom,cerebral edema and increased intracranial pressure always occurred.Sometimes,with compliance of fracture of cervical vertebra and spinal cord,peripheral nerve injury.If synthetic rehabilitation methods were used, good effect can be detected.
作者：唐梅 刊期： 2003年第07期
目的神经干细胞体外培养的成功是进一步研究其分化机制的基础 ,从胚胎大鼠脑室下区分离、培养、鉴定神经干细胞 (neural stem cells,NSCs),并观察其向神经元的分化情况.方法分离胚胎 SD大鼠脑室下区的组织,采用无血清原代及传代培养方法,获得具有克隆能力的细胞群;应用免疫细胞化学方法鉴定神经干细胞并检测分化后特异性成熟神经细胞抗原的表达;应用流式细胞检测技术观测神经干细胞随时间向神经元的分化情况.结果从胚胎大鼠脑室下区分离培养的细胞群具有克隆增殖能力,表达神经上皮干细胞蛋白( nestin),分化后的细胞表达神经元、星形胶质细胞和少突胶质细胞的特异性抗原;随着贴壁后分化时间的延长,表达 nestin的细胞数量从 80.5%下降到 10.9%,而神经元特异性烯醇化酶( neuron specific enolase,NSE)阳性细胞数量则从 1.1%上升到 31.6%.结论用本方法分离的细胞具有自我更新和增殖能力,并具有多分化潜能,是中枢神经系统的干细胞;随着分化时间的延长,神经干细胞数量下降,而神经元比例有明显上升.
作者：张瑞国；万琪；李力；俞英欣；曹云新 刊期： 2003年第07期
MATERIALS AND METHODS Materials 2 cases were diagnosed as arrhythmia without clear reasons by ECG and were confirmed that they didn't suffered organic diseases.All the cases received anti- arrhythmia and heart muscle nutrition drugs and didn't gain good effects.
作者：林绵辉；陈镇荣 刊期： 2003年第07期
中国组织工程研究杂志
主管:中华人民共和国卫生部
主办：中国康复医学会,《中国组织工程研究与临床康复》杂志社
