李康增;郑建明;郑志雄;彭友敬;张秀英;潘彬政
手足徐动是中医肝肾不足、虚风内动、风痰上扰的表现,治疗即要化痰熄风又要兼顾补肝肾之不足.用中药汤剂半夏白术天麻汤合六味地黄丸加减口服可以滋阴化痰熄风,温灸百会、风府以振奋阳气于阳中求阴,穴位注射药物营养神经.治疗手足徐动型脑性瘫痪取得了较好的疗效.
作者:刘卫民;袁海斌;黄笑;周雪娇 刊期: 2003年第07期
BACKGROUND:Brain stem auditory evoked potential(BAEP) can objectively reflex nerve conduction function of auricular conduction pathway and indirectively reflex functional status of the brain stem.
作者:魏明辉;王玉洁;姜新;陈晓虹 刊期: 2003年第07期
目的观察大鼠永久性大脑中动脉阻塞( pMCAO)后,相应区域 DNA断裂损伤情况,探讨 DNA单链损伤在 pMCAO所致脑组织损伤中的意义.方法采用常规 HE组织染色明确大鼠 pMCAO模型成功与否及其损伤范围,采用 DNA聚合酶- 1 Klenow片段原位杂交方法检测 pMCAO不同时间点 DNA单链断裂损伤情况.结果损伤区域单链 DNA断裂的 Klenow阳性细胞在 pMCAO后 6 h即有表达( P< 0.01),在 24 h时达到高峰( P< 0.01), 72 h时有所下降( P< 0.01).结论单链 DNA断裂损伤在 pMCAO后 6 h即可出现,并逐渐积累,成为缺血半暗带内细胞损伤发展过程的重要环节,并可能预示半暗带损伤范围的不断扩大.
作者:万琪;张巍;刘勇红 刊期: 2003年第07期
AIM:To observe the expression of vascular endothelial growth factor(VEGF) and Factor VIII related antigen(FVIII- R Ag) in rats brain tissue in the border zone of the hematoma,and explore the relationship between the expression of VEGF and the brain angionesis after intracerebral hmorrhage(ICH). METHODS:Rat of model of ICH was induced by injection of collagenase physiological saline into the right caudate nucleus.The immunohistochemical methods were performed by using different antisera of VEGF and FVIII- R Ag in serial sections of rats brain at 12 h,1 d,3 d and 7 d after ICH respectively.RESULTS:The amount of VEGF positive cells was markedly increased,and reached the highest at 7th day in the border zone after ICG(P< 0.01),but there were no significant difference among the mean value of A of cells at different time points (P >0.05).Compared with the controls,both the FVIII- R Ag positive endothelial cells and the A of cells were significantly different in experimental ICH goups after 1 day.CONCLUSION:The upregulated expression of VEGF might induce proliferation of endothelial cell and angiogenesis in the border zone after ICH in rats.
作者:揣兰香;张微微;戴卫平 刊期: 2003年第07期
BACKGROUND:Brain tissue is often thought as the most vigorous organ and is very sensitive to hypoxia.Hyperbaric oxygenation means improving blood oxygen content for decreasing the brain harm caused by stroke.Anaerobic metabolism of brain tissue decreases and aerobic metabolism increases,which cause more power and accelerate clearing of acidic product of metabolism,so provide fine material base for regeneration of neural tissue and recovery of neural function.
作者:杨晓娟;李凯;何韬 刊期: 2003年第07期
INTRODUCTION People have paid great attention to how to elevate curative effects and decrease relapse of severe cardiac insufficiency patients in rehabilitation stage.Foreign researches showed that specific health education can enhance patients' self- care ability,ameliorate prognosis and decrease relapse.Our research tried to elevate rehabilitation nurse quality of senile patients through rehabilitation guide of senile severe cardiac insufficiency patients in recovery stage.
作者:罗仕兰;江洁 刊期: 2003年第07期
作者: 刊期: 2003年第07期
目的胰岛素样生长因子- 1(IGF- 1)已被证实具有神经营养和保护功能,然而对其在弥漫性脑损伤 (DBI)中的作用还知之甚少,该研究探讨 DBI后大鼠脑皮层 IGF- 1及其受体 (IGF- 1R)表达的变化及意义.方法用 Marmarou方法制作大鼠弥漫性脑损伤模型,用免疫组织化学方法观察伤后不同时间大鼠脑皮层 IGF- 1及 IGF- 1R的表达.结果致伤后皮层 IGF- 1阳性细胞数 3 d后开始增加, 7 d后达到高峰, 14 d后恢复正常水平; IGF- 1R表达在实验过程中无显著变化.结论 IGF- 1参与了 DBI的病理生理过程,可能为临床治疗重型颅脑损伤提供新的理论依据.
作者:苏军;章翔;吴景文 刊期: 2003年第07期
MATERIALS AND METHODS Materials 42 cases of female patients were client from hospital,with age ranging from 38 to 55 years(average 46 years).Disease course was franging from 0.5 to 6.0 years.
作者:谢珍 刊期: 2003年第07期
目的研究碱性成纤维细胞生长因子 (basic fibroblast growth factor, bFGF)在大鼠短暂大脑中动脉阻塞 (MCAO)再灌注后不同时点表达的变化,进一步探讨 bFGF对局灶性脑缺血的脑保护作用,为治疗缺血性脑血管病提供实验基础和依据.方法采用栓线法 MCAO动物模型 ,通过免疫组化方法观察 bFGF的表达情况.结果免疫阳性细胞主要在神经元和神经胶质细胞中的表达, bFGF在缺血再灌注后 6 h开始表达 ,1 d时达高峰 ,3 d时开始下降 , 7 d时有少量表达.结论短暂 MCAO后 bFGF表达上调 ,提示 bFGF的表达增加对缺血脑组织有保护作用.
作者:王静娥;张朝东 刊期: 2003年第07期
INTRODUCTION Inflammatory reaction induced by cell immunology is the important mechanism of neuron injury, degenertion and progressive necrosis during ischemia- reperfusion course[1- 2].Human leucocyte antigen- II(HLA- II) is mainly expressed by presenting antigen presenting cell(APC).While HLA- DR antigen expressed mainly on the activated T cells and had a highly specificity and played an important role in immunology reaction and immunology adjustment[2].In our experiment,we explored research in CD3/CD(16+ 56) and CD3/HLA- DR by employing monocolonel antibody and immunology fluorescent labeling and FCM technology.
作者:谭峰;顾卫;黄涛;王金良;吴海科;黄彪 刊期: 2003年第07期
目的研究新生大鼠缺氧缺血时脑内血红素氧化酶- 1( HO- 1)和内源性一氧化碳( CO)及环化鸟苷酸( cGMP)的变化,探讨锌原卟啉( Znpp)的治疗作用.方法 7 d SD大鼠随机分为假手术对照组,缺氧缺血组( HI)及缺氧缺血+锌原卟啉组( HI+ Znpp).利用分光光度法测定血 COHb含量和脑匀浆 HO- 1活性;放免法测定脑匀浆 cGMP水平,并观察脑病理改变.结果 HI组在 1, 4, 12 h HO- 1、 cGMP、 CO水平与对照组比明显升高( P< 0.01),在 12 h达到高峰; HI+ Znpp组 HO- 1、 cGMP、 CO水平在 1, 4, 12 h均明显低于 HI组( P< 0.01),但仍高于对照组( P< 0.01).脑组织病理检查可见 HI组呈重度缺氧缺血改变,多数神经元细胞肿胀变性;而 Znpp组神经元变性者少.结论 HI后脑内 HO- 1活性明显增高导致内源性 CO和 cGMP增高, Znpp可阻抑这一病理生理过程,减轻脑损伤.
作者:王玲;张薇;惠延平 刊期: 2003年第07期
INTRODUCTION Recently,death rate of stroke acute stage decreased dramatically due to improvement of diagnosis,salvage and treatment in cerebral vascular.However,mutilation rate increased.In order to relieve disable and improve ability of daily life in stroke patients,early rehabilitation care should be taken in acute stroke patients to get better effects.
作者:逄桂英 刊期: 2003年第07期
INTRODUCTION 856 cases of severe trachoma were treated from May 1984 by freezing combined with drugs,the effects were satisfying.
作者:于亚东;张东航;王永毅 刊期: 2003年第07期
目的探讨功能磁共振 (blood oxygenation level dependent functional MRI, BOLD fMRI)在临床医学方面的应用价值.方法对 1例右侧顶叶单发转移瘤患者在手术前、后分别进行了双侧动手试验的脑功能成像.结果脑功能成像准确地反映了运动功能激活区的位置及激活程度,肿瘤侧运动区可因肿瘤占位效应产生移位,手术前的手动试验潜在功能区并未被激活,但是在肿瘤切除术后,主运动区 M1以外可见潜在重组的功能区激活.结论脑内重要功能区肿瘤切除术患者,应常规进行术前和术后 fMRI的研究,这对于提高术后患者生活质量、避免医源性损伤或将其减至低水平有极大的帮助.
作者:张磊;金真;曾亚伟;王彦;郑冬;续元超 刊期: 2003年第07期
丘脑出血是脑卒中的一种类型 , 丘脑卒中后肩痛严重影响脑卒中患者的情绪及功能恢复.为探讨磁疗治疗丘脑出血后肩痛疗效,应用磁疗方法治疗丘脑出血后肩痛患者 11例 ,均取得明显疗效 ,提示磁疗法对改善丘脑出血后肩痛有效.
作者:王旭 刊期: 2003年第07期
INTRODUCTION Encephalopathy tarda of CO intoxication is the result of incomplete therapy or in- timely treatment of acut intermedium or severe CO intoxication leading to a series of nerve system injury.Due to long period of course,serious condition and unlcrear mechanism,therapy is difficult and poor effect.
作者:杨金华;王金春 刊期: 2003年第07期
脑损害患者存在的语义范畴特异性损伤现象激发了人们对语义知识神经表征规则的研究.传统的神经心理学检查法及功能成像技术是研究语义记忆神经基础的主要方法.神经心理学是通过研究患者脑损伤部位与其损伤的语义知识范畴间的关系来推断语义知识的神经基础;而功能成像技术是通过直接检测正常人在提取各范畴语义知识时的脑活动模式来揭示语义知识的神经基础.因此,作为语义记忆探测材料的认知任务的设置直接影响到研究的效度与结果.因各研究所用的认知任务不同,研究结果与结论也呈现出较大的分歧,部分学者认为语义记忆是一单一的统一体,但部分学者认为语义记忆是一由类别子系统或是通道子系统组成的集合体.
作者:金花;莫雷;陈卓铭 刊期: 2003年第07期
目的研究帕金森病 (Parkinson disease, PD)患者睡眠障碍的特点及相关因素.方法对 45例 PD患者和 40例正常对照者,进行 Epworth Sleepiness Scale (ESS)问卷及 Zung' s self- rating depression scale (SDS)的评估.结果 PD组:睡眠障碍发生率为 67%.其中,白天过度困倦 12例 (27% ),失眠 10例 (22% ),睡眠呼吸暂停 5例 (11% ),不宁腿 3例 (7% ), ESS评分 10± 3, SDS评分 43± 8.对照者:睡眠障碍发生率为 15%.PD睡眠障碍相关因素:年龄: 60岁以下和 60岁以上患者睡眠障碍分别为 33%和 42% (P >0.05);患病时间: 5年以下和 5年以上睡眠障碍分别为 22%和 61% (P< 0.05);病情严重度:轻度和中、重度患者睡眠障碍分别为 10%和 51% (P< 0.05);每日服多巴胺量: 600 mg以下和 600 mg以上患者睡眠障碍分别为 29%和 86% (P< 0.05);抑郁程度 (SDS评分 ):得分 < 40分和 >40分睡眠障碍分别为 18%和 54% (P< 0.05).结论 PD伴睡眠障碍的发生率明显高于对照组.PD睡眠障碍的类型主要是白天过度困倦及失眠.PD睡眠障碍的发生与病程、病情严重度、抑郁及多巴胺能药物剂量有关,与增龄无关.
作者:彭海;李颍;李方明;梅元武 刊期: 2003年第07期
BACKGROUND:Magnetopolarization quantum blood QOG treatment means using auto- venous blood or other people's blood of same type 150 to 200 ml and transferring back to body after external anticoagulation.
作者:张谦;郑世文 刊期: 2003年第07期